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公开(公告)号：US12109269B2
公开(公告)日：2024-10-08
申请号：US18175956
申请日：2023-02-28
Applicant: LOYOLA UNIVERSITY OF CHICAGO
Inventor： Daniel Paul Becker , Marlon Ray Lutz, Jr.
CPC classification number: A61K41/0095 , A61K47/545 , C07F7/0814
Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.
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2.发明申请公开(公告)号：US20190084932A1
公开(公告)日：2019-03-21
申请号：US15742947
申请日：2016-07-11
Inventor： Daniel Paul Becker , Cory Reidl , Maxwell Moore , Tahirah K. Heath , Walter Fast
IPC: C07D209/08 , C07D403/12 , C07D401/12 , C07D249/04 , A61P31/04
Abstract: Indoline and tetrahydroquinoline sulfonyl compounds that can inhibit DapE and/or bacterial metallo-62 -lactamases (“MBLs”), such as NDM-1 are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the compounds disclosed herein.
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公开(公告)号：US11590226B2
公开(公告)日：2023-02-28
申请号：US17256403
申请日：2019-06-28
Applicant: LOYOLA UNIVERSITY OF CHICAGO
Inventor： Daniel Paul Becker , Marlon Ray Lutz, Jr.
Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.
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公开(公告)号：US10385040B2
公开(公告)日：2019-08-20
申请号：US15501489
申请日：2015-08-12
Applicant: LOYOLA UNIVERSITY OF CHICAGO , MARQUETTE UNIVERSITY
Inventor： Daniel Paul Becker , Richard C. Holz , Tahirah K. Heath , Cory Reidl , Anna Starus
IPC: A61K31/4439 , A61K31/404 , C07D209/10 , C07D209/08 , C07D401/12 , C07D403/12
Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
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5.发明公开公开(公告)号：US20240050571A1
公开(公告)日：2024-02-15
申请号：US18175956
申请日：2023-02-28
Applicant: LOYOLA UNIVERSITY OF CHICAGO
Inventor： Daniel Paul Becker , Marlon Ray Lutz, JR.
CPC classification number: A61K41/0095 , A61K47/545 , C07F7/0814
Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.
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Patent Agency Ranking
公开(公告)号：US20210290763A1
公开(公告)日：2021-09-23
申请号：US17256403
申请日：2019-06-28
Applicant: LOYOLA UNIVERSITY OF CHICAGO
Inventor： Daniel Paul Becker , Marlon Ray Lutz
Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) inhibitors and agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: Formula (I) wherein the substituents are as described.
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公开(公告)号：US20170226090A1
公开(公告)日：2017-08-10
申请号：US15501489
申请日：2015-08-12
Applicant: LOYOLA UNIVERSITY OF CHICAGO , MARQUETTE UNIVERSITY , Board of Regents, The University of Texas System
Inventor： Daniel Paul Becker , Richard C. Holz , Tahirah K. Heath , Cory Reidl , Anna Starus , Walter Fast
IPC: C07D403/12 , C07D401/12 , C07D209/10
CPC classification number: C07D403/12 , C07D209/08 , C07D209/10 , C07D401/12
Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
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8.发明申请公开(公告)号：US20220227792A1
公开(公告)日：2022-07-21
申请号：US17616559
申请日：2020-06-15
Applicant: LOYOLA UNIVERSITY OF CHICAGO
Inventor： Daniel Paul Becker , Sebastian Flieger , Isaac Schwarz
IPC: C07F5/02 , C07D401/12 , C07D279/12 , C07D213/42 , C07D265/30
Abstract: Disclosed herein are novel carborane hydroxamic acid matrix metalloproteinase (“MMP”) agents bearing borane-containing moieties and methods for their use in treating or preventing a disease, such as cancer and rheumatoid arthritis. In particular, disclosed herein are compounds of Formula (I) and (II) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
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公开(公告)号：US11021469B2
公开(公告)日：2021-06-01
申请号：US16514921
申请日：2019-07-17
Inventor： Daniel Paul Becker , Tahirah K. Heath , Cory Reidl , Walter Fast
IPC: A61K31/404 , A61K31/4439 , C07D209/10 , C07D209/08 , C07D401/12 , C07D403/12
Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
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公开(公告)号：US20190337931A1
公开(公告)日：2019-11-07
申请号：US16514921
申请日：2019-07-17
Inventor： Daniel Paul Becker , Tahirah K. Heath , Cory Reidl , Walter Fast
IPC: C07D403/12 , C07D209/10 , C07D401/12 , C07D209/08
Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-β-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.
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