公开(公告)号：US20190240166A1

公开(公告)日：2019-08-08

申请号：US16388364

申请日：2019-04-18

Applicant: LTS Lohmann Therapie-Systeme AG ,  Photonamic GmbH

Inventor： Tobias JUNG ,  Michael HORSTMANN ,  Gerd HOFFMANN

IPC: A61K9/70 ,  A61K31/197 ,  A61K31/195

CPC classification number: A61K9/7061 ,  A61K31/195 ,  A61K31/197

Abstract: The invention relates to a transdermal therapeutic system that includes a back layer that is impermeable to an active ingredient; a polymer matrix containing the active ingredient and a protective layer that can be pulled off. The active ingredient is 5-aminolevulinic acid hydrochloride and the basic polymer of the polymer matrix is an adhesive polyacrylate. The inventive transdermal therapeutic systems are suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.

公开(公告)号：US20190231710A1

公开(公告)日：2019-08-01

申请号：US16380069

申请日：2019-04-10

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael HORSTMANN ,  Mohammad SAMETI ,  Tobias JUNG

IPC: A61K9/70

Abstract: The present invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.