公开(公告)号：US20190134254A1

公开(公告)日：2019-05-09

申请号：US16239862

申请日：2019-01-04

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael HORSTMANN ,  Christian HAUSEN ,  Patrick MOHR ,  Karin LUDWIG ,  Tobias KLEUDGEN

IPC: A61L15/44 ,  A61L15/58 ,  A61L15/24

Abstract: The present invention relates to adhesive bandages provided with a water-vapor permeable back layer and an adhesive layer, in which the adhesive layer includes 10 weight percent of a disperse internal phase of hydrophilic particles that are water-swellable in an outer phase that includes at least 10 weight percent of a styrene block copolymer and at least 20 weight percent of an ester resin of colophony, and that can further contain at least one anti-virus substance.

公开(公告)号：US20200179666A1

公开(公告)日：2020-06-11

申请号：US16637382

申请日：2018-08-08

Applicant: LTS LOHMANN THERAPIE-SYSTEME AG

Inventor： Michael HORSTMANN ,  Roman HADASCHIK ,  Uwe WORTMANN

IPC: A61F13/40 ,  A61M5/158

Abstract: The invention relates to an adapter system comprising a frame and a lid that supports an active ingredient pad and serves to close said frame, the active ingredient pad being inserted into the frame in an operating position. The frame and the lid are interconnected force-fittingly and/or form-fittingly when in the operating position. The present invention makes it possible to position the active ingredient pad with precision.

公开(公告)号：US20180133165A1

公开(公告)日：2018-05-17

申请号：US15867050

申请日：2018-01-10

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael HORSTMANN ,  Gerd HOFFMANN ,  Sandra WIEDERSBERG

IPC: A61K9/70 ,  A61K38/27 ,  A61K38/24

Abstract: The invention relates to a transdermal therapeutic system (TTS), which is suited for the administration of a peptide to a patient through skin treated with ablation. The transdermal therapeutic system includes a back layer and an active substance-containing layer that contains at least one peptide and a carrier substance, preferably as a textile web material.

公开(公告)号：US20190231710A1

公开(公告)日：2019-08-01

申请号：US16380069

申请日：2019-04-10

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael HORSTMANN ,  Mohammad SAMETI ,  Tobias JUNG

IPC: A61K9/70

Abstract: The present invention relates to a transdermal therapeutic system, preferably a transdermal patch, having an active ingredient-containing matrix formed substantially of a water-insoluble base material, such as rubber and synthetic polymers, into which is incorporated water-soluble and/or water-swellable inclusion bodies, e.g. inclusion bodies formed from polyvinyl alcohol or polyethylene glycol, that further include micronized or nanoscale active ingredient particles.

公开(公告)号：US20160324799A1

公开(公告)日：2016-11-10

申请号：US15216446

申请日：2016-07-21

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael HORSTMANN ,  Walter Mueller

IPC: A61K9/70 ,  A61F13/02 ,  A61K31/4468

CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer-based layer which is remote from the skin with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer-based layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the polymer-based layer remote from the skin and the skin-contact layer.

Abstract translation: 一种透皮治疗系统，其用于施用至少一种活性药物成分，包括以至少80g / m 2的施用速率远离皮肤的聚合物基层和与所述皮肤接触层相邻的粘合剂皮肤接触层 聚合物层远离皮肤，并且基于丙烯酸酯共聚物，其施用速率不超过50g / m 2。 至少一种活性药物成分存在于远离皮肤的聚合物基层和皮肤接触层中。

公开(公告)号：US20190298662A1

公开(公告)日：2019-10-03

申请号：US16443766

申请日：2019-06-17

Applicant: LTS Lohmann Therapie-Systeme AG ,  Gruenenthal GmbH

Inventor： René EIFLER ,  Michael HORSTMANN ,  Regine KAUFMANN ,  Patrick MOHR ,  Eric GALIA ,  Wolfgang PRANGE ,  Stefan BULLER ,  Klaus PUSECKER ,  Jan STAMPFUSS ,  Susanne STOELBEN

IPC: A61K9/70 ,  A61K31/13

Abstract: The invention relates to transdermal therapeutic systems (TTS) which include, as active ingredient, the NMDA receptor antagonist memantine or one of its physiologically compatible salts. The TTSs can be produced and used for treating diseases of the central nervous system.

公开(公告)号：US20190240166A1

公开(公告)日：2019-08-08

申请号：US16388364

申请日：2019-04-18

Applicant: LTS Lohmann Therapie-Systeme AG ,  Photonamic GmbH

Inventor： Tobias JUNG ,  Michael HORSTMANN ,  Gerd HOFFMANN

IPC: A61K9/70 ,  A61K31/197 ,  A61K31/195

CPC classification number: A61K9/7061 ,  A61K31/195 ,  A61K31/197

Abstract: The invention relates to a transdermal therapeutic system that includes a back layer that is impermeable to an active ingredient; a polymer matrix containing the active ingredient and a protective layer that can be pulled off. The active ingredient is 5-aminolevulinic acid hydrochloride and the basic polymer of the polymer matrix is an adhesive polyacrylate. The inventive transdermal therapeutic systems are suitable for diagnosing and treating preliminary stages of skin cancer, such as actinic keratosis, and oncological skin diseases.

公开(公告)号：US20150238437A1

公开(公告)日：2015-08-27

申请号：US14709126

申请日：2015-05-11

Applicant: LTS Lohmann Therapie-Systeme AG

Inventor： Michael HORSTMANN ,  Walter Mueller

IPC: A61K9/70

CPC classification number: A61K9/7061 ,  A61F13/02 ,  A61F13/0233 ,  A61F13/0246 ,  A61K9/7053 ,  A61K9/7084 ,  A61K31/4468 ,  A61L15/44 ,  A61L2300/402

Abstract: A transdermal therapeutic system for administering at least one active pharmaceutical ingredient, including a polymer layer which is remote from the skin and is based on polyisobutylenes with a rate of application of at least 80 g/m2, and an adhesive skin-contact layer which is adjacent to the polymer layer remote from the skin and is based on acrylate copolymers with a rate of application of not more than 50 g/m2. The at least one active pharmaceutical ingredient is present in both the layer remote from the skin and the skin-contact layer.

Abstract translation: 一种透皮治疗系统，其用于施用至少一种活性药物成分，所述活性药物成分包括远离皮肤并基于聚异丁烯的施用率至少为80g / m 2的聚合物层和粘合剂皮肤接触层 邻近远离皮肤的聚合物层，并且基于丙烯酸酯共聚物，其施用速率不超过50g / m 2。 所述至少一种活性药物成分存在于远离皮肤的层和皮肤接触层中。