公开(公告)号：US20220267339A1

公开(公告)日：2022-08-25

申请号：US17738370

申请日：2022-05-06

申请人： LUPIN LIMITED

发明人： Prathap Sreedharan Nair ,  Ganesh Bhausaheb Gudade ,  Sachin Sethi ,  Dipak Raychand Lagad ,  Chetan Sanjay Pawar ,  Mahadeo Bhaskar Tryambake ,  Chaitanya Prabhakar Kulkarni ,  Anil Kashiram Hajare ,  Balasaheb Arjun Gore ,  Sanjeev Anant Kulkarni ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D487/04 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

摘要： The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

公开(公告)号：US20230119316A1

公开(公告)日：2023-04-20

申请号：US17789293

申请日：2020-12-27

申请人： Lupin Limited

发明人： Sanjay Pralhad Kurhade ,  Prathap Sreedharan Nair ,  Sachin Sethi ,  Manojkumar Ramprasad Shukla ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj ,  Samiron Phukan ,  Pradeep Rangrao Patil ,  Sayyed Majid ,  Ramesh Phadatare ,  Navnath Walke ,  Vipul Pachpute ,  Balasaheb Gore ,  Vikas Tambe ,  Rohan Limaye ,  Avadhut Bhosale ,  Sachin Mahangare

IPC分类号： C07D498/04 ,  A61K31/5383 ,  C07D491/052 ,  A61K31/519 ,  C07D487/04 ,  C07D471/04 ,  C07D487/10 ,  C07D491/20 ,  C07D498/20 ,  A61P35/00

摘要： Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, wherein, ring A, ring B, R1 to R4, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

公开(公告)号：US20230013778A1

公开(公告)日：2023-01-19

申请号：US17775679

申请日：2020-11-28

申请人： LUPIN LIMITED

发明人： Sachin Sethi ,  Prathap Sreedharan Nair ,  Manojkumar Ramprasad Shukla ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj ,  Samiron Phukan ,  Pradeep Rangrao Patil ,  Ganesh Kakade ,  Nilesh Raghunath Khedkar ,  Dagadu Dube ,  Vikas Sitaram Tambe ,  Sudhakar Maruti Balgude ,  Pradip Balu Wagh

IPC分类号： C07D403/12 ,  C07D405/12 ,  C07D491/048 ,  A61P35/00

摘要： Disclosed are compounds of the general formula (I), its tautomeric form, its stereoisomer, its pharmaceutically acceptable salt, its polymorph, or solvate thereof, Formula (I) wherein, ring A, R1 to R5, X, Y, m, and n are as defined herein, for use as SOS1 inhibitors in the treatment of proliferative, infectious and RASopathy diseases or disorders. Also disclosed are methods of synthesizing the compound of formula I, pharmaceutical compositions containing the compound of formula I, method of treatment of proliferative, infectious and RASopathy diseases or disorder, for example, a cancer, by administering the said compound and combinations of the compound of formula I with other active ingredients.

公开(公告)号：US20220315589A1

公开(公告)日：2022-10-06

申请号：US17618042

申请日：2020-06-09

申请人： Lupin Limited

发明人： Prathap Sreedharan Nair ,  Ganesh Bhausaheb Gudade ,  Mahadeo Bhaskar Tryambake ,  Chetan Sanjay Pawar ,  Dipak Raychand Lagad ,  Chaitanya Prabhakar Kulkarni ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D487/04 ,  C07D519/00 ,  C07D401/12 ,  C07D487/14 ,  A61P35/00

摘要： The invention relates to substituted nucleoside analogues of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

公开(公告)号：US11952380B2

公开(公告)日：2024-04-09

申请号：US17738370

申请日：2022-05-06

申请人： LUPIN LIMITED

发明人： Prathap Sreedharan Nair ,  Ganesh Bhausaheb Gudade ,  Sachin Sethi ,  Dipak Raychand Lagad ,  Chetan Sanjay Pawar ,  Mahadeo Bhaskar Tryambake ,  Chaitanya Prabhakar Kulkarni ,  Anil Kashiram Hajare ,  Balasaheb Arjun Gore ,  Sanjeev Anant Kulkarni ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： A61K31/519 ,  A61K31/53 ,  A61P35/00 ,  C07D471/04 ,  C07D487/04 ,  C07D519/00

CPC分类号： C07D487/04 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

摘要： The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

公开(公告)号：US11459330B2

公开(公告)日：2022-10-04

申请号：US16772959

申请日：2018-12-13

申请人： LUPIN LIMITED

发明人： Prathap Sreedharan Nair ,  Ganesh Bhausaheb Gudade ,  Sachin Sethi ,  Dipak Raychand Lagad ,  Chetan Sanjay Pawar ,  Mahadeo Bhaskar Tryambake ,  Chaitanya Prabhakar Kulkarni ,  Anil Kashiram Hajare ,  Balasaheb Arjun Gore ,  Sanjeev Anant Kulkarni ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/519 ,  A61K31/53 ,  A61P35/00 ,  C07D519/00

摘要： The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.

公开(公告)号：US20210163486A1

公开(公告)日：2021-06-03

申请号：US16772959

申请日：2018-12-13

申请人： LUPIN LIMITED

发明人： Prathap Sreedharan Nair ,  Ganesh Bhausaheb Gudade ,  Sachin Sethi ,  Dipak Raychand Lagad ,  Chetan Sanjay Pawar ,  Mahadeo Bhaskar Tryambake ,  Chaitanya Prabhakar Kulkarni ,  Anil Kashiram Hajare ,  Balasaheb Arjun Gore ,  Sanjeev Anant Kulkarni ,  Milind Dattatraya Sindkhedkar ,  Venkata P. Palle ,  Rajender Kumar Kamboj

IPC分类号： C07D487/04 ,  A61P35/00 ,  C07D519/00 ,  C07D471/04

摘要： The invention relates to substituted bicyclic heterocyclic compounds of formula (I), pharmaceutically acceptable salts thereof and pharmaceutical compositions for treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme. The invention also relates to methods of treating diseases, disorders or conditions associated with the overexpression of PRMT5 enzyme.