公开(公告)号：US11655442B2

公开(公告)日：2023-05-23

申请号：US16954235

申请日：2018-12-31

申请人： LUXEMBOURG INSTITUTE OF SCIENCE AND TECHNOLOGY (LIST)

发明人： Arno Gutleb ,  Tommaso Serchi ,  Mathieu Gerard

IPC分类号： C12M1/42 ,  C12M1/00 ,  C12M1/34

CPC分类号： C12M35/04 ,  C12M29/14 ,  C12M41/14 ,  C12M41/40

摘要： A system for incubating one or more cells and/or organotypic cultures for biological investigation, in particular for toxicology assessment, comprising a bio-incubator and a pressure system fluidly connected with the bio-incubator. The pressure system is a cyclic gas pressure system configured for cyclically varying the gas pressure in the bio-incubator between a negative pressure and a positive pressure compared to the atmospheric pressure, so as to reproduce the pressure conditions in lungs of a living mammal. The system is remarkable in that the cyclic gas pressure system comprises a feedthrough with a pipe configured to deviate the air influx from the one or more cells and/or organotypic cultures.