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公开(公告)号:US07745587B2
公开(公告)日:2010-06-29
申请号:US11648423
申请日:2006-12-29
申请人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号: C07K16/40 , C07K16/00 , A61K39/395
CPC分类号: C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译: 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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2.
公开(公告)号:US09051377B2
公开(公告)日:2015-06-09
申请号:US13335185
申请日:2011-12-22
申请人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号: A61K39/395 , C07K16/40 , A61K51/10 , C07K16/30 , G01N33/573 , A61K39/00
CPC分类号: C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译: 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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公开(公告)号:US08106168B2
公开(公告)日:2012-01-31
申请号:US12776195
申请日:2010-05-07
申请人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号: C07K16/40 , C07K16/00 , A61K39/395
CPC分类号: C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译: 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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公开(公告)号:US20120107231A1
公开(公告)日:2012-05-03
申请号:US13335185
申请日:2011-12-22
申请人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号: A61K39/395 , A61P35/00 , A61K51/00
CPC分类号: C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译: 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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公开(公告)号:US20100266490A1
公开(公告)日:2010-10-21
申请号:US12776195
申请日:2010-05-07
申请人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
发明人: Laetitia Devy , Henk Pieters , Robert C. Ladner , Rene Hoet , Daniel T. Dransfield , Clive R. Wood , Maria Henderikx
IPC分类号: A61K51/10 , C07K16/40 , C07K16/18 , A61K39/395 , A61K49/00 , A61P3/10 , A61P19/10 , A61P25/28 , A61P29/00 , A61P35/00 , G01N33/53 , C12N9/99
CPC分类号: C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译: 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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公开(公告)号:US20100196361A1
公开(公告)日:2010-08-05
申请号:US12317074
申请日:2008-12-17
IPC分类号: A61K39/395 , C07K16/18 , A61P35/04
CPC分类号: C07K16/2863 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
摘要翻译: Tie1和Tie2是受体酪氨酸激酶蛋白,其包括跨膜结构域。 Tie1和Tie2存在于内皮细胞上。 本公开描述了结合Tie1,Tie2和Ang的试剂,例如抗体,包括抑制内皮细胞活性和血管生成的抗体。 这些药剂可用于治疗血管生成相关疾病。
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公开(公告)号:US07871610B2
公开(公告)日:2011-01-18
申请号:US11049536
申请日:2005-02-02
IPC分类号: A61K39/395 , C07K16/28 , C12P21/08 , G01N33/53
CPC分类号: C07K16/005 , C07K16/2863 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/00
摘要: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
摘要翻译: Tie1和Tie2是受体酪氨酸激酶蛋白,其包括跨膜结构域。 Tie1和Tie2存在于内皮细胞上。 本公开描述了结合Tie1,Tie2和Ang的试剂,例如抗体,包括抑制内皮细胞活性的抗体。
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公开(公告)号:US20110059105A1
公开(公告)日:2011-03-10
申请号:US12824823
申请日:2010-06-28
IPC分类号: A61K39/395 , C07K16/40 , G01N33/573 , A61P35/00 , A61P29/00
CPC分类号: C07K16/005 , C07K16/2863 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/00
摘要: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity.
摘要翻译: Tie1和Tie2是受体酪氨酸激酶蛋白,其包括跨膜结构域。 Tie1和Tie2存在于内皮细胞上。 本公开描述了结合Tie1,Tie2和Ang的试剂,例如抗体,包括抑制内皮细胞活性的抗体。
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公开(公告)号:US07485297B2
公开(公告)日:2009-02-03
申请号:US11199739
申请日:2005-08-09
IPC分类号: A61K39/395 , C07K16/28 , C07K16/00 , C12P21/08 , G01N33/53
CPC分类号: C07K16/2863 , A61K2039/505 , C07K16/005 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要: Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
摘要翻译: Tie1和Tie2是受体酪氨酸激酶蛋白,其包括跨膜结构域。 Tie1和Tie2存在于内皮细胞上。 本公开描述了结合Tie1,Tie2和Ang的试剂,例如抗体,包括抑制内皮细胞活性和血管生成的抗体。 这些药剂可用于治疗血管生成相关疾病。
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公开(公告)号:US20070217997A1
公开(公告)日:2007-09-20
申请号:US11648423
申请日:2006-12-29
申请人: Laetitia Devy , Henk Pieters , Robert Ladner , Rene Hoet , Daniel Dransfield , Clive Wood
发明人: Laetitia Devy , Henk Pieters , Robert Ladner , Rene Hoet , Daniel Dransfield , Clive Wood
IPC分类号: A61K51/00 , G01N33/574 , A61K39/395 , C07K16/30
CPC分类号: C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要: Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译: 描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。
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