利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

18 条记录 (耗时 0.019 秒)

    Anthraquinone compound
    1.
    发明授权
    Anthraquinone compound 失效
    蒽醌化合物

    公开(公告)号：US06777564B2

    公开(公告)日：2004-08-17

    申请号：US10022411

    申请日：2001-12-20

    申请人： Lain-Tze Lee ,  Jinun-Ban Yeh

    发明人： Lain-Tze Lee ,  Jinun-Ban Yeh

    IPC分类号： C07D30734

    CPC分类号： C09B1/40 ,  A61K31/16 ,  A61K31/221 ,  A61K31/403 ,  C07C50/34

    摘要： A novel compound with anthraquinone structure and having the following foluma (I): wherein R1, R2 and R3 each independently is hydrogen, hydroxy, amino or C1-6 alkyl group; R4 is hydrogen, C1-18 alkyl carbonyl, C1-6 alkyl group substituted by at least a functional group; R5 is hydrogen amino or a group of the following formula wherein R1, R2, R3 and R4 are defined as the above; and R and R′ each independently is hydrogen, hydroxyl, amino, C1-6 alkyl group or a group of the following formula wherein R1, R2, R3 and R4 are defined as the above.

    摘要翻译： 具有蒽醌结构的新化合物，具有以下组分（I）：其中R 1，R 2和R 3各自独立地为氢，羟基，氨基或C 1-6烷基; R4是氢，C1-18烷基羰基，至少被官能团取代的C1-6烷基; R5是氢氨基或下列化学式的基团，R1，R2，R3和R4定义如上; 并且R和R'各自独立地为氢，羟基，氨基，C 1-6烷基或下列化学式的基团，R 1，R 2，R 3和R 4如上所定义。

    Method for the preparation of .DELTA..sup.3 -7-substituted amino desacetoxy cephalosporanic acid
    4.
    发明授权
    Method for the preparation of .DELTA..sup.3 -7-substituted amino desacetoxy cephalosporanic acid 失效
    制备δ3-7取代氨基脱乙酰氧基头孢菌酸的方法

    公开(公告)号：US5302713A

    公开(公告)日：1994-04-12

    申请号：US861232

    申请日：1992-03-31

    申请人： Jinun B. Yeh ,  Lain-Tze Lee ,  Mei-Hueih Chen

    发明人： Jinun B. Yeh ,  Lain-Tze Lee ,  Mei-Hueih Chen

    IPC分类号： C07D501/00 ,  C07D501/22 ,  C07D501/10

    CPC分类号： C07D501/00

    摘要： A method for synthesizing .DELTA..sup.3 -7-substituted amino desacetoxy cephalosporanic acid from a penicillin sulfoxide or its alkylsilylated ester derivative is provided. According to the method, penicillin sulfoxide is heated in the presence of an organic ammonium salt catalyst and a copolymer composed of dimethylsilane and urea units until formation of the cephalosporanic acid occurs by ring expansion reaction. The copolymer functions both as a dehydrating agent for removing the water by-product generated from the reaction as well as an esterifying agent for converting penicillin sulfoxide into its dimethylsilyl ester derivative. The method of the invention produces high yields of the cephalosporanic acid and avoids the need for excess dimethylsilyating agents.

    摘要翻译： 提供了从青霉素亚砜或其烷基硅烷化酯衍生物合成DELTA 3-7-取代氨基脱乙酰氧基头孢菌酸的方法。 根据该方法，在有机铵盐催化剂和由二甲基硅烷和尿素单元组成的共聚物存在下，加热青霉素亚砜，直到通过环扩展反应发生形成头孢菌酸。 该共聚物既用作去除由反应产生的水副产物的脱水剂也用作将青霉素亚砜转化为其二甲基甲硅烷基酯衍生物的酯化剂。 本发明的方法产生高产率的头孢菌酸，避免了对过量的二甲基甲硅烷基化剂的需要。

    Herbal composition for treating allergic disorders and method for making the same
    7.
    发明授权
    Herbal composition for treating allergic disorders and method for making the same 有权
    用于治疗过敏性疾病的草药组合物及其制备方法

    公开(公告)号：US06958162B2

    公开(公告)日：2005-10-25

    申请号：US10608005

    申请日：2003-06-30

    申请人： Rong-Ming Lyu ,  I-Hong Pan ,  Jir-mehng Lo ,  Sue-Fen Jiang ,  Sheau-Ni Su ,  Nai-Yun Hsu ,  Shih Cheng Shen ,  Hsin-Chieh Wu ,  Lain-Tze Lee ,  Yih-Loong Lai ,  Jaw-Ji Tsai

    发明人： Rong-Ming Lyu ,  I-Hong Pan ,  Jir-mehng Lo ,  Sue-Fen Jiang ,  Sheau-Ni Su ,  Nai-Yun Hsu ,  Shih Cheng Shen ,  Hsin-Chieh Wu ,  Lain-Tze Lee ,  Yih-Loong Lai ,  Jaw-Ji Tsai

    IPC分类号： A61K36/076 ,  A61K36/539 ,  A61K36/884 ,  A61K36/8945 ,  A61K35/78

    CPC分类号： A61K36/8945 ,  A61K36/076 ,  A61K36/539 ,  A61K36/884 ,  Y10S514/826

    摘要： Pharmaceutical compositions for treating immunological disorders and the preparing method of the same are disclosed, which include alcohol extracts of Radix Dioscorea, Rhizoma Alismatis, Poria cocos (schw) Wolf, and Scutellaria Baicalensis. The compositions are manufactured by novel procedures consisting of decocting using specific concentration ranges of alcohol, filtering, regulating pH value, purifying, concentrating, proportionally mixing, and making a granule powder from lyophilized extract. This invention used both in vitro and in vivo assays to evaluate therapeutic effects of specific combination of herbal plant extracts. The combination of herbal extracts has been able to maximize the anti-inflammatory activity and regulate the secretion of cytokines such as eotaxin and IL-4. When the pharmaceutical composition of the present invention is used for asthma, it can relieve coughs, resist airway allergic inflammation reactions, improve the pulmonary functions, reduce allergen specific IgE in bloods, stabilize elasmatoblasts, and stop the attacks from asthma.

    摘要翻译： 本发明公开了用于治疗免疫学障碍的药物组合物及其制备方法，其包括薯include皂甙，枸杞，茯苓（Schw）狼和黄芩的酒精提取物。 组合物通过新鲜的方法制备，该方法由使用特定浓度范围的酒精煎煮，过滤，调节pH值，纯化，浓缩，比例混合和由冻干提取物制成颗粒粉末组成。 本发明使用体外和体内测定来评估草药植物提取物的特定组合的治疗效果。 草药提取物的组合已经能够最大化抗炎活性并调节细胞因子如嗜酸细胞活化趋化因子和IL-4的分泌。 当本发明的药物组合物用于哮喘时，可以缓解咳嗽，抵抗气道变应性炎症反应，改善肺功能，降低血液中过敏原特异性IgE，稳定成骨细胞，并阻止哮喘发作。

    Pharmaceutical composition and method for preventing or treating hepatitis C
    8.
    发明授权
    Pharmaceutical composition and method for preventing or treating hepatitis C 有权
    用于预防或治疗丙型肝炎的药物组合物和方法

    公开(公告)号：US09289443B2

    公开(公告)日：2016-03-22

    申请号：US13281441

    申请日：2011-10-26

    申请人： Lain-Tze Lee ,  Shau-Feng Chang ,  Zong-Keng Kuo ,  Hui-Ping Tsai

    发明人： Lain-Tze Lee ,  Shau-Feng Chang ,  Zong-Keng Kuo ,  Hui-Ping Tsai

    IPC分类号： A61K31/704

    CPC分类号： A61K31/704

    摘要： A pharmaceutical composition for preventing or treating hepatitis C is provided, including oleanolic acid derivatives as an active ingredient and a pharmaceutically acceptable carrier. A method for preventing or treating hepatitis C in a subject in need thereof is also provided by administering the subject the pharmaceutical composition given above.

    摘要翻译： 提供了用于预防或治疗丙型肝炎的药物组合物，包括齐墩果酸衍生物作为活性成分和药学上可接受的载体。 通过给予受试者以上给出的药物组合物还提供了预防或治疗有需要的受试者中丙型肝炎的方法。