公开(公告)号：US20080206103A1

公开(公告)日：2008-08-28

申请号：US11662696

申请日：2005-09-14

申请人： Lal A. Pinnaduwage ,  Thomas G. Thundat ,  Gilbert M. Brown ,  Peter V. Bonnesen ,  Vassil Boiadjiev ,  Gudron Goretzki

发明人： Lal A. Pinnaduwage ,  Thomas G. Thundat ,  Gilbert M. Brown ,  Peter V. Bonnesen ,  Vassil Boiadjiev ,  Gudron Goretzki

IPC分类号： B01J19/00 ,  C07D323/00 ,  C07C43/215

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N29/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

摘要： Methods for the preparation of a stable, self-assembled monolayer on the silicon surface or metallic coating of a microcantilever are disclosed. The methods produce a microcantilever suitable as a chemical sensor. In a microcantilever produced using one version of the method, a metallic coating is disposed on a side of the microcantilever, a bridging atom is bonded to the metallic coating, a first spacer group is bonded to the bridging atom, a second spacer group is bonded to the bridging atom, and a chemical recognition agent is bonded to the first spacer group. In another version of the method, a silicon surface of a microcantilever is hydrogen terminated, and a calixarene chemical recognition agent is carbon linked to the silicon surface using photochemical hydrosilylation. Among other things, the calixarene may be bonded to a crown ether for ion detection or bonded to a area for the recognition of explosives by hydrogen bonding to nitro groups.

摘要翻译： 公开了在微型悬臂梁的硅表面或金属涂层上制备稳定的自组装单层的方法。 该方法产生适合作为化学传感器的微悬臂梁。 在使用一种方法制造的微悬臂梁中，金属涂层设置在微悬臂梁的一侧，桥接原子与金属涂层结合，第一间隔基团与桥连原子键合，第二间隔基团键合 并且化学识别剂与第一间隔基团结合。 在该方法的另一种方案中，微悬臂梁的硅表面是氢封端的，并且杯芳烃化学识别剂使用光化学氢化硅烷化将碳连接到硅表面。 其中，杯芳烃可以结合到冠醚用于离子检测，或者通过氢键连接到硝基而与用于识别爆炸物的区域结合。