公开(公告)号：US20080085379A1

公开(公告)日：2008-04-10

申请号：US11859047

申请日：2007-09-21

申请人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

发明人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

IPC分类号： B05D3/10

CPC分类号： G01N29/022 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N2291/0256 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

摘要： Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.

摘要翻译： 用于检测特定试剂（如铬酸盐，汽油和生物物种）的高灵敏度传感器平台，使用微型悬臂梁和其表面已经用光化学附着的有机单层如自组装单层（SAM）进行了改性的其他微机电系统（MEMS） 或金 - 硫醇表面连接。 微悬臂传感器使用光化学氢化硅烷化来改性硅表面和金 - 硫醇化学，以改变金属表面，从而使多单元阵列芯片中的单个微悬臂梁可以单独修改。 具有多种分子识别位点的末端乙烯基取代的烃可以通过光化学氢化硅烷化方法连接到硅的表面。 通过将激活的UV光依次聚焦在选定的硅或氮化硅氢终止表面上，并用有机硫醇，硫化物或二硫化物浸泡或点样选定的金属表面，微悬臂梁被功能化。 该装置和光化学方法旨在集成到用于检测特定试剂的系统中，包括铬酸盐地下水污染物，汽油和生物物质。

公开(公告)号：US20060057026A1

公开(公告)日：2006-03-16

申请号：US11152627

申请日：2005-06-14

申请人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

发明人： Vassil Boiadjiev ,  Gilbert Brown ,  Lal Pinnaduwage ,  Thomas Thundat ,  Peter Bonnesen ,  Gudrun Goretzki

IPC分类号： G01N31/00 ,  G01N27/416 ,  B32B37/02 ,  B05D5/12 ,  B05D3/00

CPC分类号： G01N29/022 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01N2291/0256 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427

摘要： Highly sensitive sensor platforms for the detection of specific reagents, such as chromate, gasoline and biological species, using microcantilevers and other microelectromechanical systems (MEMS) whose surfaces have been modified with photochemically attached organic monolayers, such as self-assembled monolayers (SAM), or gold-thiol surface linkage are taught. The microcantilever sensors use photochemical hydrosilylation to modify silicon surfaces and gold-thiol chemistry to modify metallic surfaces thereby enabling individual microcantilevers in multicantilever array chips to be modified separately. Terminal vinyl substituted hydrocarbons with a variety of molecular recognition sites can be attached to the surface of silicon via the photochemical hydrosilylation process. By focusing the activating UV light sequentially on selected silicon or silicon nitride hydrogen terminated surfaces and soaking or spotting selected metallic surfaces with organic thiols, sulfides, or disulfides, the microcantilevers are functionalized. The device and photochemical method are intended to be integrated into systems for detecting specific agents including chromate groundwater contamination, gasoline, and biological species.

摘要翻译： 用于检测特定试剂（如铬酸盐，汽油和生物物种）的高灵敏度传感器平台，使用微型悬臂梁和其表面已经用光化学附着的有机单层如自组装单层（SAM）进行了改性的其他微机电系统（MEMS） 或金 - 硫醇表面连接。 微悬臂传感器使用光化学氢化硅烷化来改性硅表面和金 - 硫醇化学，以改变金属表面，从而使多单元阵列芯片中的单个微悬臂梁可以单独修改。 具有多种分子识别位点的末端乙烯基取代的烃可以通过光化学氢化硅烷化方法连接到硅的表面。 通过将激活的UV光依次聚焦在选定的硅或氮化硅氢终止表面上，并用有机硫醇，硫化物或二硫化物浸泡或点样选定的金属表面，微悬臂梁被功能化。 该装置和光化学方法旨在集成到用于检测特定试剂的系统中，包括铬酸盐地下水污染物，汽油和生物物质。

公开(公告)号：US20080206103A1

公开(公告)日：2008-08-28

申请号：US11662696

申请日：2005-09-14

申请人： Lal A. Pinnaduwage ,  Thomas G. Thundat ,  Gilbert M. Brown ,  Peter V. Bonnesen ,  Vassil Boiadjiev ,  Gudron Goretzki

发明人： Lal A. Pinnaduwage ,  Thomas G. Thundat ,  Gilbert M. Brown ,  Peter V. Bonnesen ,  Vassil Boiadjiev ,  Gudron Goretzki

IPC分类号： B01J19/00 ,  C07D323/00 ,  C07C43/215

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  G01N29/022 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

摘要： Methods for the preparation of a stable, self-assembled monolayer on the silicon surface or metallic coating of a microcantilever are disclosed. The methods produce a microcantilever suitable as a chemical sensor. In a microcantilever produced using one version of the method, a metallic coating is disposed on a side of the microcantilever, a bridging atom is bonded to the metallic coating, a first spacer group is bonded to the bridging atom, a second spacer group is bonded to the bridging atom, and a chemical recognition agent is bonded to the first spacer group. In another version of the method, a silicon surface of a microcantilever is hydrogen terminated, and a calixarene chemical recognition agent is carbon linked to the silicon surface using photochemical hydrosilylation. Among other things, the calixarene may be bonded to a crown ether for ion detection or bonded to a area for the recognition of explosives by hydrogen bonding to nitro groups.

摘要翻译： 公开了在微型悬臂梁的硅表面或金属涂层上制备稳定的自组装单层的方法。 该方法产生适合作为化学传感器的微悬臂梁。 在使用一种方法制造的微悬臂梁中，金属涂层设置在微悬臂梁的一侧，桥接原子与金属涂层结合，第一间隔基团与桥连原子键合，第二间隔基团键合 并且化学识别剂与第一间隔基团结合。 在该方法的另一种方案中，微悬臂梁的硅表面是氢封端的，并且杯芳烃化学识别剂使用光化学氢化硅烷化将碳连接到硅表面。 其中，杯芳烃可以结合到冠醚用于离子检测，或者通过氢键连接到硝基而与用于识别爆炸物的区域结合。

公开(公告)号：US20060191320A1

公开(公告)日：2006-08-31

申请号：US11059170

申请日：2005-02-16

申请人： Lal Pinnaduwage ,  Thomas Thundat ,  Gilbert Brown ,  John Hawk ,  Vassil Boiadjiev

发明人： Lal Pinnaduwage ,  Thomas Thundat ,  Gilbert Brown ,  John Hawk ,  Vassil Boiadjiev

IPC分类号： G01N29/02 ,  G01N29/00

CPC分类号： G01N29/022 ,  G01N29/036 ,  G01N29/2418 ,  G01N2291/0224 ,  G01N2291/0255 ,  G01N2291/0256 ,  G01N2291/0427

摘要： A chemically functionalized cantilever system has a cantilever coated on one side thereof with a reagent or biological species which binds to an analyte. The system is of particular value when the analyte is a toxic chemical biological warfare agent or an explosive.

摘要翻译： 化学功能化的悬臂系统在其一侧上具有悬臂，其具有结合分析物的试剂或生物物质。 当分析物是有毒化学生物战剂或爆炸物时，该系统是特别有价值的。