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公开(公告)号：US20130230894A1
公开(公告)日：2013-09-05
申请号：US13802320
申请日：2013-03-13
IPC分类号： C12P7/08
摘要： The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of a substrate comprising CO. It more particularly relates to the addition of an inorganic sulfur source to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to alcohols. In a particular embodiment, a microbial culture is provided with sodium polysulfide, wherein a substrate comprising CO is converted to products including ethanol and 2,3-butanediol.
摘要翻译： 本发明涉及通过微生物发酵对醇的生产的改进，特别是通过包含CO的底物的微生物发酵来生产醇。更特别地涉及向发酵系统添加无机硫源，使得一个或多个微 - 有机物将包含CO的底物转化为醇。 在一个具体实施方案中，微生物培养物具有多硫化钠，其中将包含CO的底物转化为包括乙醇和2,3-丁二醇的产物。
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公开(公告)号：US08658408B2
公开(公告)日：2014-02-25
申请号：US13777806
申请日：2013-02-26
发明人： Sean Dennis Simpson , Loan Phuong Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , FungMin Liew , Shane Fleming
IPC分类号： C12P5/00
摘要： The invention provides method for producing butanediol and specifically 2,3-butanediol by anaerobic fermentation of a gaseous substrate comprising CO by a culture of at least one micro-organism. In accordance with particular methods of the invention, 2,3-butanediol is produced by anaerobic fermentation of substrates including carbohydrates and carbon monoxide. The invention further provides for the up-regulation of a native 2,3-butanediol dehydrogenase gene in the at least one micro-organism. The 2,3-butanediol can be further converted to compounds such as butene(s), butadiene and methyl ethyl ketone. These compounds can be further converted to chemical products such as 2-butanol.
摘要翻译： 本发明提供了通过至少一种微生物的培养物通过包含CO的气态底物的厌氧发酵来生产丁二醇和特别是2,3-丁二醇的方法。 根据本发明的具体方法，2,3-丁二醇通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生。 本发明还提供了至少一种微生物中天然2,3-丁二醇脱氢酶基因的上调。 2,3-丁二醇可以进一步转化为化合物，如丁烯，丁二烯和甲基乙基酮。 这些化合物可以进一步转化成化学产物如2-丁醇。
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公开(公告)号：US20130177955A1
公开(公告)日：2013-07-11
申请号：US13777806
申请日：2013-02-26
发明人： Sean Dennis Simpson , Loan Phuong Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , FungMin Liew , Shane Fleming
IPC分类号： C12P7/18
摘要： The invention provides method for producing butanediol and specifically 2,3-butanediol by anaerobic fermentation of a gaseous substrate comprising CO by a culture of at least one micro-organism. In accordance with particular methods of the invention, 2,3-butanediol is produced by anaerobic fermentation of substrates including carbohydrates and carbon monoxide. The invention further provides for the up-regulation of a native 2,3-butanediol dehydrogenase gene in the at least one micro-organism. The 2,3-butanediol can be further converted to compounds such as butene(s), butadiene and methyl ethyl ketone. These compounds can be further converted to chemical products such as 2-butanol.
摘要翻译： 本发明提供了通过至少一种微生物的培养物通过包含CO的气态底物的厌氧发酵来生产丁二醇和特别是2,3-丁二醇的方法。 根据本发明的具体方法，2,3-丁二醇通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生。 本发明还提供了至少一种微生物中天然2,3-丁二醇脱氢酶基因的上调。 2,3-丁二醇可以进一步转化为化合物，如丁烯，丁二烯和甲基乙基酮。 这些化合物可以进一步转化成化学产物如2-丁醇。
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