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公开(公告)号：US10724059B2
公开(公告)日：2020-07-28
申请号：US14360645
申请日：2012-12-05
申请人： LanzaTech New Zealand Limited , Frank Benkwitz , Christophe Daniel Mihalcea , Alice Marie Havill
摘要： This invention relates generally to method for producing products, particularly alcohols, by microbial fermentation. In particular, the invention relates to methods for increasing the efficiency of the fermentation, by providing a method for treating the used fermentation broth to produce a treated permeate which is then passed back to the bioreactor. The invention provides a method whereby at least one treatment step used to treat the permeated, produces a gaseous product which is then used in one or more stages of the fermentation process.
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公开(公告)号：US20130177955A1
公开(公告)日：2013-07-11
申请号：US13777806
申请日：2013-02-26
发明人： Sean Dennis Simpson , Loan Phuong Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , FungMin Liew , Shane Fleming
IPC分类号： C12P7/18
摘要： The invention provides method for producing butanediol and specifically 2,3-butanediol by anaerobic fermentation of a gaseous substrate comprising CO by a culture of at least one micro-organism. In accordance with particular methods of the invention, 2,3-butanediol is produced by anaerobic fermentation of substrates including carbohydrates and carbon monoxide. The invention further provides for the up-regulation of a native 2,3-butanediol dehydrogenase gene in the at least one micro-organism. The 2,3-butanediol can be further converted to compounds such as butene(s), butadiene and methyl ethyl ketone. These compounds can be further converted to chemical products such as 2-butanol.
摘要翻译： 本发明提供了通过至少一种微生物的培养物通过包含CO的气态底物的厌氧发酵来生产丁二醇和特别是2,3-丁二醇的方法。 根据本发明的具体方法，2,3-丁二醇通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生。 本发明还提供了至少一种微生物中天然2,3-丁二醇脱氢酶基因的上调。 2,3-丁二醇可以进一步转化为化合物，如丁烯，丁二烯和甲基乙基酮。 这些化合物可以进一步转化成化学产物如2-丁醇。
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公开(公告)号：US08906655B2
公开(公告)日：2014-12-09
申请号：US13872646
申请日：2013-04-29
发明人： Will David Barker , Bjorn Daniel Heijstra , Wing Chuen Chan , Christophe Daniel Mihalcea , Loan Phuong Tran , Christophe Collet , Jason Carl Bromley , Bakir Al-Sinawi
摘要： The invention relates to a process for optimizing the production of ethanol by microbial fermentation, particularly microbial fermentation of substrates comprising CO. The process involves monitoring the hydrogen production by the microorganism, determining an optimum hydrogen production and adjusting the substrate supply rate in response to a change in the hydrogen production thereby keeping the hydrogen production within a desired range.
摘要翻译： 本发明涉及通过微生物发酵优化乙醇生产的方法，特别是包含CO的底物的微生物发酵方法，该方法包括监测微生物的氢产生，确定最佳的氢产生并响应于 改变氢气产生，从而将氢气产生保持在期望的范围内。
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公开(公告)号：US20130230894A1
公开(公告)日：2013-09-05
申请号：US13802320
申请日：2013-03-13
IPC分类号： C12P7/08
摘要： The invention relates to improvements in the production of alcohols by microbial fermentation, particularly to production of alcohols by microbial fermentation of a substrate comprising CO. It more particularly relates to the addition of an inorganic sulfur source to a fermentation system such that one or more micro-organisms convert a substrate comprising CO to alcohols. In a particular embodiment, a microbial culture is provided with sodium polysulfide, wherein a substrate comprising CO is converted to products including ethanol and 2,3-butanediol.
摘要翻译： 本发明涉及通过微生物发酵对醇的生产的改进，特别是通过包含CO的底物的微生物发酵来生产醇。更特别地涉及向发酵系统添加无机硫源，使得一个或多个微 - 有机物将包含CO的底物转化为醇。 在一个具体实施方案中，微生物培养物具有多硫化钠，其中将包含CO的底物转化为包括乙醇和2,3-丁二醇的产物。
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公开(公告)号：US09771603B2
公开(公告)日：2017-09-26
申请号：US14493287
申请日：2014-09-22
发明人： Kathleen Frances Smart , Alexander Paul Mueller , Michael James Harry Mawdsley , Christophe Daniel Mihalcea
IPC分类号： C12P7/18
CPC分类号： C12P7/18 , C12Y202/01006 , Y02E50/17 , Y02P20/52
摘要： A methods for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The methods comprises increasing production of one or more products derived from acetolactate. Further provided is a method for increasing the production of 2,3-butandiol by microbial fermentation of gaseous substrates, the method comprising providing a compound which inhibits one or more enzymes which convert acetolactate to branched chain amino acids to the fermentation. The present invention further provides methods for increasing the production of 2,3-butandiol relative to other fermentation products such as ethanol and acetic acid.
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公开(公告)号：US08658408B2
公开(公告)日：2014-02-25
申请号：US13777806
申请日：2013-02-26
发明人： Sean Dennis Simpson , Loan Phuong Tran , Christophe Daniel Mihalcea , Jennifer Mon Yee Fung , FungMin Liew , Shane Fleming
IPC分类号： C12P5/00
摘要： The invention provides method for producing butanediol and specifically 2,3-butanediol by anaerobic fermentation of a gaseous substrate comprising CO by a culture of at least one micro-organism. In accordance with particular methods of the invention, 2,3-butanediol is produced by anaerobic fermentation of substrates including carbohydrates and carbon monoxide. The invention further provides for the up-regulation of a native 2,3-butanediol dehydrogenase gene in the at least one micro-organism. The 2,3-butanediol can be further converted to compounds such as butene(s), butadiene and methyl ethyl ketone. These compounds can be further converted to chemical products such as 2-butanol.
摘要翻译： 本发明提供了通过至少一种微生物的培养物通过包含CO的气态底物的厌氧发酵来生产丁二醇和特别是2,3-丁二醇的方法。 根据本发明的具体方法，2,3-丁二醇通过包括碳水化合物和一氧化碳在内的底物的厌氧发酵产生。 本发明还提供了至少一种微生物中天然2,3-丁二醇脱氢酶基因的上调。 2,3-丁二醇可以进一步转化为化合物，如丁烯，丁二烯和甲基乙基酮。 这些化合物可以进一步转化成化学产物如2-丁醇。
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公开(公告)号：US20130252230A1
公开(公告)日：2013-09-26
申请号：US13872646
申请日：2013-04-29
发明人： Will David Barker , Bjorn Daniel Heijstra , Wing Chuen Chan , Christophe Daniel Mihalcea , Loan Phuong Tran , Christophe Collet , Jason Carl Bromley , Bakir Al-Sinawi
IPC分类号： C12Q3/00
摘要： The invention relates to a process for optimising the production of ethanol by microbial fermentation, particularly microbial fermentation of substrates comprising CO. The process involves monitoring the hydrogen production by the microorganism, determining an optimum hydrogen production and adjusting the substrate supply rate in response to a change in the hydrogen production thereby keeping the hydrogen production within a desired range.
摘要翻译： 本发明涉及通过微生物发酵优化乙醇生产的方法，特别是包含CO的底物的微生物发酵方法，该方法包括监测微生物的氢产生，确定最佳的氢产生并响应于 改变氢气产生，从而将氢气产生保持在期望的范围内。
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公开(公告)号：US20130260429A1
公开(公告)日：2013-10-03
申请号：US13851772
申请日：2013-03-27
摘要： This invention relates generally to methods for increasing the efficiency of microbial growth and production of products, such as alcohols and acids by microbial fermentation of substrates containing carbon monoxide. More particularly the invention relates to the provision of an alternative sulphur source to a liquid nutrient medium, such that sulphur is available to one or more microorganisms of the fermentation.
摘要翻译： 本发明一般涉及通过微生物发酵含有一氧化碳的底物来提高微生物生长和产生产物如醇和酸的效率的方法。 更具体地，本发明涉及向液体营养培养基提供替代硫源，使得硫可用于一种或多种发酵微生物。
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公开(公告)号：US10358662B2
公开(公告)日：2019-07-23
申请号：US15422424
申请日：2017-02-01
发明人： Sean Dennis Simpson , Robert John Conrado , Christophe Daniel Mihalcea , Michael Emerson Martin
摘要： The invention provides schemes for the integration of a fermentation process, with an electrolysis process, and a C1-generating industrial process. In particular, the invention provides process for utilizing electrolysis products, for example H2 and/or O2, to improve the process efficiency of at least one of the fermentation process or the C1-generating industrial process. More particularly, the invention provides a process whereby, H2 generated by electrolysis is used to improve the substrate efficiency for a fermentation process, and the O2 generated by the electrolysis process is used to improve the composition of the C1-containing tail gas generated by the C1-generating industrial process.
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公开(公告)号：US20170218404A1
公开(公告)日：2017-08-03
申请号：US15422424
申请日：2017-02-01
CPC分类号： C12P7/065 , C12M43/00 , C12M45/07 , C12P7/16 , C12P7/18 , C12P7/54 , C25B1/00 , C25B1/003 , C25B1/04 , C25B15/08 , Y02E50/17 , Y02E60/366 , Y02P20/133
摘要： The invention provides schemes for the integration of a fermentation process, with an electrolysis process, and a C1-generating industrial process. In particular, the invention provides process for utilizing electrolysis products, for example H2 and/or O2, to improve the process efficiency of at least one of the fermentation process or the C1-generating industrial process. More particularly, the invention provides a process whereby, H2 generated by electrolysis is used to improve the substrate efficiency for a fermentation process, and the O2 generated by the electrolysis process is used to improve the composition of the C1-containing tail gas generated by the C1-generating industrial process.
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