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    Fermentation process
    1.
    发明授权
    Fermentation process 有权

    公开(公告)号：US09771603B2

    公开(公告)日：2017-09-26

    申请号：US14493287

    申请日：2014-09-22

    申请人： LanzaTech New Zealand Limited

    发明人： Kathleen Frances Smart ,  Alexander Paul Mueller ,  Michael James Harry Mawdsley ,  Christophe Daniel Mihalcea

    IPC分类号： C12P7/18

    CPC分类号： C12P7/18 ,  C12Y202/01006 ,  Y02E50/17 ,  Y02P20/52

    摘要： A methods for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The methods comprises increasing production of one or more products derived from acetolactate. Further provided is a method for increasing the production of 2,3-butandiol by microbial fermentation of gaseous substrates, the method comprising providing a compound which inhibits one or more enzymes which convert acetolactate to branched chain amino acids to the fermentation. The present invention further provides methods for increasing the production of 2,3-butandiol relative to other fermentation products such as ethanol and acetic acid.

    FERMENTATION PROCESS
    2.
    发明申请
    FERMENTATION PROCESS 有权
    发酵过程

    公开(公告)号：US20150087037A1

    公开(公告)日：2015-03-26

    申请号：US14493287

    申请日：2014-09-22

    申请人： LanzaTech New Zealand Limited

    发明人： Kathleen Frances Smart ,  Alexander Paul Mueller ,  Michael James Harry Mawdsley ,  Christophe Daniel Mihalcea

    IPC分类号： C12P7/18

    CPC分类号： C12P7/18 ,  C12Y202/01006 ,  Y02E50/17 ,  Y02P20/52

    摘要： A methods for altering the metabolite profile of a fermentation, by increasing flux through acetolactate. The methods comprises increasing production of one or more products derived from acetolactate. Further provided is a method for increasing the production of 2,3-butandiol by microbial fermentation of gaseous substrates, the method comprising providing a compound which inhibits one or more enzymes which convert acetolactate to branched chain amino acids to the fermentation. The present invention further provides methods for increasing the production of 2,3-butandiol relative to other fermentation products such as ethanol and acetic acid.

    摘要翻译： 通过增加通过乙酰乳酸的通量来改变发酵的代谢物分布的方法。 所述方法包括增加一种或多种由乙酰乳酸衍生的产物的产生。 还提供了通过气态底物的微生物发酵来增加2,3-丁二醇生产的方法，该方法包括提供抑制一种或多种将乙酰乳酸转化为支链氨基酸的酶发酵的化合物。 本发明还提供了相对于其它发酵产物如乙醇和乙酸增加2,3-丁二醇生产的方法。

    FERMENTATION PROCESS FOR THE PRODUCTION AND CONTROL OF PYRUVATE-DERIVED PRODUCTS
    5.
    发明申请
    FERMENTATION PROCESS FOR THE PRODUCTION AND CONTROL OF PYRUVATE-DERIVED PRODUCTS 有权
    用于生产和控制紫外线衍生产品的发酵方法

    公开(公告)号：US20150337341A1

    公开(公告)日：2015-11-26

    申请号：US14283287

    申请日：2014-05-21

    申请人： LanzaTech New Zealand Limited

    发明人： Kathleen Frances Smart ,  Boi San Ly

    IPC分类号： C12P7/18 ,  C12P7/06

    CPC分类号： C12P7/18 ,  C12P7/065 ,  C12P7/16 ,  C12P7/26 ,  C12P7/46 ,  C12P7/56 ,  Y02E50/10 ,  Y02E50/17

    摘要： A process for producing and controlling pyruvate derived products during the fermentation of a CO containing substrate by an acetogenic carboxydotrophic microorganism has been developed. The process involves increasing the concentration of at least one nutrient selected from the group consisting of vitamin B1, vitamin B5, vitamin B7 and mixtures thereof above the cellular requirement of the microorganism. When the concentration is increased, the production of 2,3-butanediol (2,3-BDO) increases whereas the production of the other metabolites is virtually unchanged. The effect is reversible so that when the concentration is decreased, the production of 2,3-BDO is also decreased. This allows one to control the ratio of ethanol:2,3-BDO to a desired value which can vary from about 4:1 to about 1:2.

    摘要翻译： 已经开发了一种通过产乙酸营养型微生物在含CO底物的发酵过程中生产和控制丙酮酸衍生产物的方法。 该方法包括增加选自维生素B1，维生素B5，维生素B7及其混合物中的至少一种营养素的浓度，高于微生物的细胞要求。 当浓度增加时，2,3-丁二醇（2,3-BDO）的产量增加，而其他代谢产物的产量几乎没有变化。 效果是可逆的，因此当浓度降低时，2,3-BDO的产量也降低。 这允许将乙醇：2,3-BDO的比例控制在可以从约4:1至约1:2变化的期望值。