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公开(公告)号:US08691747B2
公开(公告)日:2014-04-08
申请号:US13879635
申请日:2011-10-25
IPC分类号: A61K31/00
CPC分类号: A61K39/3955 , C12N9/14 , C12N15/1137 , C12N2310/14 , C12Y306/01 , G01N33/53
摘要: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
摘要翻译: 治疗哺乳动物(例如人)中的自身免疫性和炎性疾病或病症的方法,其包括施用含有溴结构域的蛋白质的抑制剂:ATAD2。
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公开(公告)号:US20130224204A1
公开(公告)日:2013-08-29
申请号:US13879635
申请日:2011-10-25
IPC分类号: A61K39/395 , G01N33/53
CPC分类号: A61K39/3955 , C12N9/14 , C12N15/1137 , C12N2310/14 , C12Y306/01 , G01N33/53
摘要: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: ATAD2.
摘要翻译: 治疗哺乳动物(例如人)中的自身免疫性和炎性疾病或病症的方法,其包括施用含有溴结构域的蛋白质的抑制剂:ATAD2。
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公开(公告)号:US20120202875A1
公开(公告)日:2012-08-09
申请号:US13500408
申请日:2010-10-26
IPC分类号: A61K31/713 , C40B30/06 , C07H21/02 , A61P37/00 , A61P29/00
CPC分类号: G01N33/5008 , C12N15/1137 , C12N2310/14
摘要: The present invention relates to methods for treatment or prevention of autoimmune and inflammatory diseases and conditions by inhibiting or modifying histone demethylation. In a further aspect the invention relates to a method for identifying agents useful in said methods of treatment. The invention particularly describes the role of certain histone demethylase enzymes in these diseases and conditions and their use as therapeutic and screening targets.
摘要翻译: 本发明涉及通过抑制或修饰组蛋白去甲基化来治疗或预防自身免疫性和炎性疾病和病症的方法。 在另一方面,本发明涉及用于鉴定在所述治疗方法中有用的药剂的方法。 本发明特别描述了某些组蛋白脱甲基酶在这些疾病和病症中的作用及其作为治疗和筛选靶标的用途。
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公开(公告)号:US09018184B2
公开(公告)日:2015-04-28
申请号:US13883091
申请日:2011-11-23
申请人: Kevin Lee , David Francis Tough
发明人: Kevin Lee , David Francis Tough
IPC分类号: C12N15/11 , C12Q1/68 , A61K31/713 , C12N15/113
CPC分类号: A61K31/713 , C12N15/113 , C12N2310/14 , C12Q1/6876
摘要: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of bromodomain-containing protein: SP140.
摘要翻译: 治疗哺乳动物(例如人)中的自身免疫性和炎性疾病或病症的方法,其包括施用含有溴结构域的蛋白质的抑制剂:SP140。
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公开(公告)号:US20130210892A1
公开(公告)日:2013-08-15
申请号:US13879638
申请日:2011-10-25
申请人: Kevin Lee , David Francis Tough
发明人: Kevin Lee , David Francis Tough
IPC分类号: A61K31/713 , C12Q1/68
CPC分类号: A61K31/713 , C12N15/113 , C12N2310/14 , C12Q1/6876
摘要: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of the bromodomain-containing protein: SP110
摘要翻译: 治疗哺乳动物(例如人)中的自身免疫性和炎性疾病或病症的方法,其包括施用含有溴结构域的蛋白质的抑制剂:SP110
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公开(公告)号:US20130225661A1
公开(公告)日:2013-08-29
申请号:US13883091
申请日:2011-11-23
申请人: Kevin Lee , David Francis Tough
发明人: Kevin Lee , David Francis Tough
IPC分类号: A61K31/713 , C12Q1/68
CPC分类号: A61K31/713 , C12N15/113 , C12N2310/14 , C12Q1/6876
摘要: A method of treating autoimmune and inflammatory diseases or conditions in a mammal, such as a human, which comprises the administration of a inhibitor of bromodomain-containing protein: SP140.
摘要翻译: 治疗哺乳动物(例如人)中的自身免疫性和炎性疾病或病症的方法,其包括施用含有溴结构域的蛋白质的抑制剂:SP140。
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公开(公告)号:US09984164B2
公开(公告)日:2018-05-29
申请号:US13192805
申请日:2011-07-28
申请人: Eckart Walther , Qi Lu , David Ku , Kevin Lee , Chung-Man Tam , Ali Diab
发明人: Eckart Walther , Qi Lu , David Ku , Kevin Lee , Chung-Man Tam , Ali Diab
IPC分类号: G06F17/30
CPC分类号: G06F17/30867 , G06F17/30696 , G06F17/30864 , G06F17/30882 , G06F17/30935 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要: Computer systems and methods allow users to annotate content items found in a corpus such as the World Wide Web Annotations, which can include any descriptive and/or evaluative metadata related to a document, are collected from a user and stored in association with that user. Users are able to annotate and view their annotations for any document they encounter while interacting with the corpus, including hits returned in a search of the corpus. Users are also able to search their annotations or to limit searches to documents they have annotated. Metadata from annotations can also be aggregated across users and aggregated metadata applied in generating search results.
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公开(公告)号:US20160324222A1
公开(公告)日:2016-11-10
申请号:US15065544
申请日:2016-03-09
申请人: Beverly Ann Deal , Rebecca Harmon , Kevin Lee
发明人: Beverly Ann Deal , Rebecca Harmon , Kevin Lee
CPC分类号: A41C3/065 , A41C3/0007 , A41C5/005
摘要: A bra comprised of separate left and right breast support members where each breast support member comprises a section of flexible sheet material formed to define a concave cavity and having tabs projecting radially outwardly from the cavity rim. Each breast support member defines a rear facing surface encompassing the cavity and tabs, which carries a pressure sensitive adhesive for adhering to a user's skin. The concave cavity constitutes a cup for accommodating the user's breast while the tabs enable the user to readily manipulate the support member for optimally positioning the user's breast relative to the cut of a deep plunge garment.
摘要翻译: 一种由单独的左和右乳房支撑构件组成的胸罩,其中每个乳房支撑构件包括形成为限定凹腔的柔性片材的一部分,并且具有从腔缘径向向外突出的突出部。 每个乳房支撑构件限定包围空腔和突出部的后向表面,该表面携带用于粘附到使用者皮肤的压敏粘合剂。 凹腔构成用于容纳使用者的乳房的杯子,而翼片使得使用者能够容易地操纵支撑构件,以便相对于深穿衣服的切口最佳地定位使用者的乳房。
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公开(公告)号:US09489463B2
公开(公告)日:2016-11-08
申请号:US13104569
申请日:2011-05-10
申请人: Eckart Walther , Qi Lu , David Ku , Kevin Lee , Chung-Man Tam , Ali Diab
发明人: Eckart Walther , Qi Lu , David Ku , Kevin Lee , Chung-Man Tam , Ali Diab
IPC分类号: G06F17/30
CPC分类号: G06F17/30867 , G06F17/30696 , G06F17/30864 , G06F17/30882 , G06F17/30935 , Y10S707/99942 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要: Computer systems and methods allow users to annotate content items found in a corpus such as the World Wide Web. Annotations, which can include any descriptive and/or evaluative metadata related to a document, are collected from a user and stored in association with that user. Users are able to annotate and view their annotations for any document they encounter while interacting with the corpus, including hits returned in a search of the corpus. Users are also able to search their annotations or to limit searches to documents they have annotated. Metadata from annotations can also be aggregated across users and aggregated metadata applied in generating search results.
摘要翻译: 计算机系统和方法允许用户注释在诸如万维网的语料库中发现的内容项。 可以包括与文档相关的任何描述性和/或评估性元数据的注释,从用户收集并与该用户相关联地存储。 用户可以在与语料库进行交互的同时,为他们遇到的任何文档注释并查看其注释,包括在语料库搜索中返回的命中。 用户还可以搜索其注释或将搜索限制为已注释的文档。 来自注释的元数据也可以跨用户聚合,并在生成搜索结果时应用汇总的元数据。
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