公开(公告)号：US10676520B2

公开(公告)日：2020-06-09

申请号：US13163489

申请日：2011-06-17

申请人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

发明人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

IPC分类号： A61K39/42 ,  C12N5/10 ,  C07K16/10 ,  A61K39/00

摘要： Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

公开(公告)号：US20120020971A1

公开(公告)日：2012-01-26

申请号：US13163489

申请日：2011-06-17

申请人： Lawrence M. KAUVAR ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

发明人： Lawrence M. KAUVAR ,  Stote Ellsworth ,  William Usinger ,  Krista M. McCutcheon ,  Minha Park ,  Bo Chen ,  Ying-Ping Jiang

IPC分类号： A61K39/42 ,  A61P31/00 ,  C12N5/10 ,  C12N15/85 ,  C12P21/08 ,  C07K16/10 ,  A61P31/16

摘要： Monoclonal antibodies and fragments thereof that are crossreactive with multiple clades of influenza virus including both Group 1 and Group 2 representatives are disclosed. These antibodies are useful in controlling influenza epidemics and pandemics as well as in providing prophylactic or therapeutic protection against seasonal influenza.

摘要翻译： 公开了与多个流感病毒进化枝交叉反应的单克隆抗体及其片段，包括第1组和第2组代表。 这些抗体可用于控制流行性感冒和大流行以及为季节性流感提供预防或治疗保护。

公开(公告)号：US09017668B2

公开(公告)日：2015-04-28

申请号：US13162497

申请日：2011-06-16

申请人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

发明人： Lawrence M. Kauvar ,  Stote Ellsworth ,  William Usinger ,  Krista Maureen McCutcheon ,  Ying-Ping Jiang ,  Fen Zhang ,  Bo Chen ,  Gizette Sperinde ,  Minha Park ,  Orit Foord

IPC分类号： A61K39/12 ,  A61K39/215 ,  C07K16/08 ,  C07K16/46

CPC分类号： C07K16/088 ,  A61K39/245 ,  A61K2039/505 ,  C07K16/08 ,  C07K16/468 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/30 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies to human Cytomegalovirus (CMV) gB protein have been isolated from human B cells. The affinities of these antibodies are higher than the best previously reported antibodies. Since high affinity is critical to prevention of virus transfer across the placenta, the invention antibodies are useful as therapeutic and prophylactic agents to prevent or ameliorate effects on the fetus of CMV infection during pregnancy.

摘要翻译： 已从人B细胞中分离出人巨细胞病毒（CMV）gB蛋白的抗体。 这些抗体的亲和力高于先前报道的最佳抗体。 由于高亲和力对于预防跨越胎盘的病毒转移至关重要，本发明的抗体可用作预防或改善对怀孕期间CMV感染胎儿的影响的治疗和预防剂。