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公开(公告)号：US20070031480A1
公开(公告)日：2007-02-08
申请号：US10548371
申请日：2004-03-08
申请人： Lawrence Mayer , Jennifer Shabbits , Marcel Bally
发明人： Lawrence Mayer , Jennifer Shabbits , Marcel Bally
IPC分类号： A61K9/127 , A61K31/685 , A61K31/56 , A61K31/739
CPC分类号： A61K31/56 , A61K9/1272 , A61K31/685 , A61K31/739
摘要： Compositions which comprise delivery vehicles having stably associated therewith at least one organic acid derivative of a sterol are useful in achieving enhanced cellular delivery of physiologically relevant sphingolipids when the compositions are administered.
摘要翻译： 包含稳定与其相关联的至少一种固醇的有机酸衍生物的递送载体的组合物可用于在施用组合物时实现生理学上相关的鞘脂的增强的细胞递送。
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公开(公告)号：US20070148255A1
公开(公告)日：2007-06-28
申请号：US11701326
申请日：2007-01-31
申请人： Paul Tardi , Troy Harasym , Murray Webb , Clifford Shew , Marcel Bally , Lawrence Mayer , Andrew Janoff , Trevor Shew , Dominic Shew
发明人： Paul Tardi , Troy Harasym , Murray Webb , Clifford Shew , Marcel Bally , Lawrence Mayer , Andrew Janoff , Trevor Shew , Dominic Shew
IPC分类号： A61K33/24 , A61K31/7072 , A61K31/704 , A61K31/4745 , A61K31/337 , A61K31/282 , A61K9/16
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Methods to prepare compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents. The compositions exhibit non-antagonistic effects when combinations of drugs are administered.
摘要翻译： 制备组合物的方法，所述组合物包含与两种或多种试剂的非拮抗组合稳定相关的递送载体。 当施用药物组合时，组合物表现出非拮抗作用。
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公开(公告)号：US20060165771A1
公开(公告)日：2006-07-27
申请号：US11304328
申请日：2005-12-14
申请人： Paul Tardi , Clifford Shew , Andrew Janoff , Lawrence Mayer , Marcel Bally , Dominic Shew , Trevor Shew
发明人： Paul Tardi , Clifford Shew , Andrew Janoff , Lawrence Mayer , Marcel Bally , Dominic Shew , Trevor Shew
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K31/00 , A61K31/133 , A61K31/17 , A61K31/337 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/575 , A61K31/685 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K39/00 , A61K45/06 , A61K2300/00
摘要： Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
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公开(公告)号：US07850990B2
公开(公告)日：2010-12-14
申请号：US10417631
申请日：2003-04-16
申请人： Paul Tardi , Troy Harasym , Murray Webb , Clifford Shew , Marcel Bally , Lawrence Mayer , Andrew Janoff
发明人： Paul Tardi , Troy Harasym , Murray Webb , Clifford Shew , Marcel Bally , Lawrence Mayer , Andrew Janoff
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1271 , A61K9/1272 , A61K31/00 , A61K31/282 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
摘要翻译： 包含与两种或多种试剂（例如抗肿瘤剂）的非拮抗组合稳定相关的递送载体的组合物在施用药物组合时可用于实现非拮抗作用。
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公开(公告)号：US20060240090A1
公开(公告)日：2006-10-26
申请号：US10551579
申请日：2004-04-02
申请人： Lawrence Mayer , Marcel Bally , Murray Webb , Paul Tardi
发明人： Lawrence Mayer , Marcel Bally , Murray Webb , Paul Tardi
IPC分类号： A61K31/7072 , A61K31/4745 , A61K9/127
CPC分类号： A61K31/4745 , A61K9/127 , A61K31/7072 , A61K2300/00
摘要： Compositions which comprise liposomes having stably associated therewith a camptothecin and a fluoropyrimidine are useful in achieving enhanced therapeutic effects when combinations of these drugs are administered.
摘要翻译： 包含与喜树碱稳定相关的脂质体和氟嘧啶的组合物在施用这些药物的组合时可用于实现增强的治疗效果。
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公开(公告)号：US20100189771A1
公开(公告)日：2010-07-29
申请号：US12091738
申请日：2006-10-25
申请人： Lawrence Mayer , Christine Swenson , Andrew Janoff , John Redman
发明人： Lawrence Mayer , Christine Swenson , Andrew Janoff , John Redman
IPC分类号： A61K31/7068 , A61P35/00 , A61K9/127
CPC分类号： A61K31/4745 , A61K31/505
摘要： Provided herein are methods for treating cancer by administering a pharmaceutical composition comprising a fixed, non-antagonistic molar ratio of irinotecan and floxuridine. Such methods are particularly useful in the treatment of cancer patients with advanced solid tumors.
摘要翻译： 本文提供了通过施用包含固定的，非拮抗摩尔比的伊立替康和氟尿苷的药物组合物来治疗癌症的方法。 这些方法特别可用于治疗晚期实体瘤的癌症患者。
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公开(公告)号：US10722464B2
公开(公告)日：2020-07-28
申请号：US16048100
申请日：2018-07-27
发明人： Paul Tardi , Troy Harasym , Murray Webb , Clifford Shew , Andrew Janoff , Lawrence Mayer , Marcel Bally
IPC分类号： A61K9/127 , A61K31/00 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K31/7048 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K45/06 , A61K31/133 , A61K31/17 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/575 , A61K31/685 , A61K31/7068 , A61K39/00
摘要： Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
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8.发明授权Fixed drug ratios for treatment of hematopoietic cancers and proliferative disorders 有权用于治疗造血癌和增殖性疾病的固定药物比例公开(公告)号：US08092828B2
公开(公告)日：2012-01-10
申请号：US12032583
申请日：2008-02-15
申请人： Arthur Louie , Christine Swenson , Lawrence Mayer , Andrew Janoff
发明人： Arthur Louie , Christine Swenson , Lawrence Mayer , Andrew Janoff
CPC分类号： A61K31/70 , A61K9/0019 , A61K9/127 , Y10T436/143333
摘要： Provided herein are methods for treating cancer by administering a pharmaceutical composition comprising a fixed, non-antagonistic molar ratio of cytarabine and an anthracycline. Such methods are particularly useful in the treatment of patients with advanced hematologic cancers or proliferative disorders.
摘要翻译： 本文提供了通过施用包含固定的，非拮抗摩尔比的阿糖胞苷和蒽环类药物的药物组合物来治疗癌症的方法。 这种方法在治疗晚期血液癌或增殖性疾病的患者中特别有用。
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公开(公告)号：US20080107722A1
公开(公告)日：2008-05-08
申请号：US11719088
申请日：2005-11-18
申请人： Paul Tardi , Murray Webb , Sharon Johnstone , Pierrot Harvie , Lawrence Mayer
发明人： Paul Tardi , Murray Webb , Sharon Johnstone , Pierrot Harvie , Lawrence Mayer
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1278
摘要： This invention relates to encapsulation of drugs and other agents into preformed delivery vehicles.
摘要翻译： 本发明涉及将药物和其它药剂包封到预成型递送载体中。
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公开(公告)号：US20050118250A1
公开(公告)日：2005-06-02
申请号：US10495666
申请日：2002-11-13
申请人： Paul Tardi , Murray Webb , Lawrence Mayer , Ludger Ickenstein
发明人： Paul Tardi , Murray Webb , Lawrence Mayer , Ludger Ickenstein
IPC分类号： A61K9/127 , A61K9/19 , A61K31/704 , A61K31/7072 , A61K33/24
CPC分类号： A61K9/1271 , A61K9/127 , A61K9/1278
摘要： Liposomes that contain at least 10 mol % of a negatively charged lipid coupled to an non-zwitterionic moiety are stable in the blood. Liposomes containing at least 1 mol % of such lipids may be frozen safely.
摘要翻译： 含有至少10摩尔％的与非两性离子部分偶联的带负电荷的脂质的脂质体在血液中是稳定的。 含有至少1摩尔％的这种脂质的脂质体可以安全地冷冻。
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