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公开(公告)号：US20230123569A1
公开(公告)日：2023-04-20
申请号：US18073120
申请日：2022-12-01
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D413/14 , C07D239/42 , C07D401/14 , C07D413/12 , C07D471/04 , C07D471/10 , C07D498/10 , C07D519/00
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
公开(公告)号：US11548883B2
公开(公告)日：2023-01-10
申请号：US16098748
申请日：2018-05-15
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D413/14 , C07D239/42 , C07D401/14 , C07D413/12 , C07D471/04 , C07D471/10 , C07D498/10 , C07D519/00
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
3.发明申请公开(公告)号：US20200172542A1
公开(公告)日：2020-06-04
申请号：US16783893
申请日：2020-02-06
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D471/04 , C07D498/10 , C07D519/00 , C07D471/10 , C07D413/14 , C07D413/12 , C07D403/14 , C07D401/14 , C07D513/04
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.
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公开(公告)号：US20170096430A1
公开(公告)日：2017-04-06
申请号：US15281355
申请日：2016-09-30
Applicant: LegoChem Biosciences, Inc.
Inventor： Hye Kyung Chang , Sung Yoon Baek , Min Jung Kim , Kyu Man Oh , Jeung Soon Choi , Soo Bong Ha , Sung Min Kim , Chul-woong Chung , Dae Hyuck Kang , Hyun Jin Kwon , Young Lag Cho , Yong Zu Kim
IPC: C07D471/08 , C07D519/00
CPC classification number: C07D471/08 , A61K31/46 , C07D519/00
Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
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公开(公告)号：US10961242B2
公开(公告)日：2021-03-30
申请号：US16783893
申请日：2020-02-06
Applicant: LegoChem Biosciences, Inc.
Inventor： Dae Yon Lee , Sang Eun Chae , Eun Mi Jung , Eun Hye Yang , Yoon Jeong Choi , Chul-Woong Chung , Ju Hyun Shin , Yun Ki Kim , Hyun Jin Kwon , Jeong Hee Ryu , Eun Hye Ban , Yong Zu Kim , Yeong Soo Oh , Jeiwook Chae
IPC: C07D471/04 , C07D498/10 , C07D519/00 , C07D471/10 , C07D413/14 , C07D413/12 , C07D403/14 , C07D401/14 , C07D513/04
Abstract: The present invention relates to novel compounds as autotoxin inhibitors for treatment and prophylaxis of conditions or a disorder caused by autotaxin activation or increased concentration of lysophosphatidic acid, and also a pharmaceutical composition containing the same.
The novel compounds of the present invention are autotoxin inhibitors, and by inhibiting the production of lysophosphatidic acid, they are useful for treatment or prophylaxis of cardiovascular disorder, cancer, metabolic disorder, kidney disorder, liver disorder, inflammatory disorder, nervous system disorder, respiratory system disorder, fibrotic disease, ocular disorder, cholestatic and other forms of chronic pruritus, or acute or chronic organ transplant rejection.-
Patent Agency Ranking
公开(公告)号：US10273235B2
公开(公告)日：2019-04-30
申请号：US15917059
申请日：2018-03-09
Applicant: LegoChem Biosciences, Inc.
Inventor： Hye Kyung Chang , Sung Yoon Baek , Min Jung Kim , Kyu Man Oh , Jeung Soon Choi , Soo Bong Ha , Sung Min Kim , Chul-woong Chung , Dae Hyuck Kang , Hyun Jin Kwon , Young Lag Cho , Yong Zu Kim
IPC: A61K31/46 , C07D471/08 , C07D519/00
Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
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公开(公告)号：US09630977B2
公开(公告)日：2017-04-25
申请号：US13691221
申请日：2012-11-30
Applicant: Legochem Biosciences, Inc.
Inventor： Young Lag Cho , Joung Yul Yun , Sang Eun Chae , Chul Soon Park , Hyang Sook Lee , Kyu Man Oh , Hye Jin Heo , Dae Hyuck Kang , Young Jae Yang , Hyun Jin Kwon , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC: C07D501/24 , C07D501/46 , C07D501/60
CPC classification number: C07D501/60 , C07D501/24 , C07D501/46
Abstract: The present invention relates to novel cephalosporin derivatives represented by X, Y, L, R1, and R2 are as same as defined in the description of the invention. The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient. According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
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8.发明申请公开(公告)号：US20130178455A1
公开(公告)日：2013-07-11
申请号：US13691221
申请日：2012-11-30
Applicant: Legochem Biosciences, Inc.
Inventor： Young Lag Cho , Joung Yul Yun , Sang Eun Chae , Chul Soon Park , Hyang Sook Lee , Kyu Man Oh , Hye Jin Heo , Dae Hyuck Kang , Young Jae Yang , Hyun Jin Kwon , Tae Kyo Park , Sung Ho Woo , Yong Zu Kim
IPC: C07D501/60
CPC classification number: C07D501/60 , C07D501/24 , C07D501/46
Abstract: The present invention relates to novel cephalosporin derivatives represented by Chemical Formula 1. Wherein, X, Y, L, R1, and R2 are as same as defined in the description of the invention.The present invention also relates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient.According to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effective ingredient for the broad spectrum of antibiotic resistant, low toxicity, particularly in Gram-negative bacteria, which can be useful with strong antimicrobial activity.
Abstract translation: 本发明涉及由化学式1表示的新型头孢菌素衍生物。其中，X，Y，L，R 1和R 2与本发明的描述中所定义相同。 本发明还涉及药物抗生素组合物，其包含由化学式1表示的新型胞孢素衍生物，其前药，其水合物，其溶剂合物，其异构体或其药学上可接受的盐作为有效成分。 根据本发明，新型头孢菌素衍生物，其前体药物，其水合物，其溶剂化物，其异构体或其药学上可接受的盐作为有效成分，用于广谱抗生素抗性，低毒性，特别是革兰氏阴性 - 阴性细菌，其可用于具有强的抗微生物活性。
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公开(公告)号：US20180194765A1
公开(公告)日：2018-07-12
申请号：US15917059
申请日：2018-03-09
Applicant: LegoChem Biosciences, Inc.
Inventor： Hye Kyung Chang , Sung Yoon Baek , Min Jung Kim , Kyu Man Oh , Jeung Soon Choi , Soo Bong Ha , Sung Min Kim , Chul-woong Chung , Dae Hyuck Kang , Hyun Jin Kwon , Young Lag Cho , Yong Zu Kim
IPC: C07D471/08 , A61K31/46 , C07D519/00
CPC classification number: C07D471/08 , A61K31/46 , C07D519/00
Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
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公开(公告)号：US09951072B2
公开(公告)日：2018-04-24
申请号：US15281355
申请日：2016-09-30
Applicant: LegoChem Biosciences, Inc.
Inventor： Hye Kyung Chang , Sung Yoon Baek , Min Jung Kim , Kyu Man Oh , Jeung Soon Choi , Soo Bong Ha , Sung Min Kim , Chul-woong Chung , Dae Hyuck Kang , Hyun Jin Kwon , Young Lag Cho , Yong Zu Kim
IPC: C07D471/08 , A61K31/46 , C07D519/00
CPC classification number: C07D471/08 , A61K31/46 , C07D519/00
Abstract: Substituted dihydroisoxazole derivatives useful as inhibitors of β-lactamases are provided. The invention further provides medical uses of substituted dihydroisoxazole derivatives, for example, as antibacterial agents.
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