公开(公告)号：US20070078085A1

公开(公告)日：2007-04-05

申请号：US11248337

申请日：2005-10-13

申请人： Leland Chung ,  Wen-Chin Huang ,  Valerie Odero-Marah ,  Daqing Wu ,  Chia-Ling Hsieh ,  Haiyen Zhau

发明人： Leland Chung ,  Wen-Chin Huang ,  Valerie Odero-Marah ,  Daqing Wu ,  Chia-Ling Hsieh ,  Haiyen Zhau

IPC分类号： A61K48/00 ,  A61K38/18 ,  C12Q1/68 ,  G01N33/574

CPC分类号： A61K31/70 ,  A61K48/00 ,  C07K16/22 ,  C07K16/2833 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  G01N33/5011

摘要： The present invention relates to compositions and methods for modulating osteomimicry within tumor and tissue cells with calcification potential. The invention further relates to screening compounds that modulate osteomimicry within tumor and tissue cells with calcification potential. Methods for using compounds identified by the screening assays for therapeutic treatments also are provided. The invention further relates to methods of treating those tumors and other diseases and disorders with calcification potential with compounds that modulate their osteomimetic potential.

摘要翻译： 本发明涉及在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的组合物和方法。 本发明进一步涉及筛选在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的化合物。 还提供了通过筛选测定法鉴定的化合物用于治疗性治疗的方法。 本发明还涉及用调节其骨骼模拟潜能的化合物治疗具有钙化潜能的那些肿瘤和其它疾病和病症的方法。

公开(公告)号：US09771625B2

公开(公告)日：2017-09-26

申请号：US13559431

申请日：2012-07-26

申请人： Jean C. Shih ,  Leland Chung ,  Haiyen E. Zhau ,  Boyang Jason Wu ,  Bogdan Z. Olenyuk

发明人： Jean C. Shih ,  Leland Chung ,  Haiyen E. Zhau ,  Boyang Jason Wu ,  Bogdan Z. Olenyuk

IPC分类号： A61K31/405 ,  A61K31/352 ,  A61K31/357 ,  A61K31/381 ,  C12N15/113 ,  A61K31/366 ,  A61K31/5375 ,  A61K31/713 ,  A61K47/48 ,  A61K49/00

CPC分类号： A61K31/137 ,  A61K31/352 ,  A61K31/357 ,  A61K31/366 ,  A61K31/381 ,  A61K31/405 ,  A61K31/5375 ,  A61K31/713 ,  A61K47/545 ,  A61K47/55 ,  A61K47/6929 ,  A61K49/0032 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12Y104/03004

摘要： A mechanism of monoamine oxidases (MAOs) driven epithelium-to-mesenchymal transition (EMT) is disclosed. Also disclosed are methods for treating cancer by inhibiting or suppressing MAOs in cancer cells. Novel MAOs inhibitors, such as small molecules, siRNA, shRNA, antisense oligonucleotides, aptamers, decoys, and pharmaceutical compositions useful for treating cancer by disrupting the workings of MAOs are provided. In particular, a class of conjugates formed by covalently conjugating near infrared dye 783, IR-780, and MHI-148 to a MAO inhibitor, such as clorgyline, with and without encapsulation it in a nanoparticle is provided. Other aspects of the invention include methods for forming the nano-conjugates, method for monitoring treatment progress in a cancer patient by monitoring the changes in MAO activity, methods for screening patients who are at risk of cancer or differentiating different forms of cancer by assaying the level and location of MAO activity.

公开(公告)号：US06572856B1

公开(公告)日：2003-06-03

申请号：US09724620

申请日：2000-11-28

申请人： Ronald Taylor ,  Alessandra Nardin ,  William M. Sutherland ,  Mitchell H. Sokoloff ,  Leland Chung

发明人： Ronald Taylor ,  Alessandra Nardin ,  William M. Sutherland ,  Mitchell H. Sokoloff ,  Leland Chung

IPC分类号： A61K39395

CPC分类号： A61K39/395 ,  A61K38/00 ,  A61K48/00 ,  A61K51/1072 ,  C07K16/18 ,  C07K16/2896 ,  C07K16/3069 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2319/00 ,  A61K2300/00

摘要： The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also relates to methods of treating and preventing cancer, viral infection, or microbial infection in an animal comprising administering to said animal IgG antibodies, IgM antibodies and/or complement components in combination with antibodies specific for C3b(i). The present invention also relates methods of treating and preventing cancer, viral infection or microbial infection in an animal comprising administrating said animal antibodies that immunospecifically bind to one or more cancer cell antigens, viral antigens or microbial antigens, respectively, in combination with antibodies immunospecific for C3b(i). The present invention further relates to the detection, imaging, diagnosis and monitoring of cancer utilizing C3b(i) specific antibodies.

摘要翻译： 本发明涉及通过施用抗C3b（i）抗体来治疗和预防癌症，病毒感染和微生物感染。 本发明还涉及治疗和预防动物中的癌症，病毒感染或微生物感染的方法，包括向所述动物IgG抗体，IgM抗体和/或补体成分与C3b（i）特异的抗体组合施用。 本发明还涉及治疗和预防动物中的癌症，病毒感染或微生物感染的方法，其包括分别将免疫特异性结合一种或多种癌细胞抗原，病毒抗原或微生物抗原的所述动物抗体与免疫特异性抗体 C3b（i）。 本发明还涉及使用C3b（i）特异性抗体的癌症的检测，成像，诊断和监测。