公开(公告)号：US07378094B2

公开(公告)日：2008-05-27

申请号：US10489564

申请日：2002-08-28

申请人： Ronald P. Taylor ,  Margaret A. Lindorfer ,  William M. Sutherland

发明人： Ronald P. Taylor ,  Margaret A. Lindorfer ,  William M. Sutherland

IPC分类号： A61K39/395

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K16/08 ,  C07K2317/54

摘要： The present invention is directed to an immune complex composition, and a method of using that complex to enhance an in viva immune response against a preselected target antigen. The immune complexes of the present invention comprise a monoclonal antibody specific for binding to complement receptor (CR2) site on B lymphocytes linked to a target antigen. As shown in FIG. SA-SD immune complexes bound to monkey B cells are removed in concert with loss of CR2. FIGS. SA and SB demonstrate the % A1488 HB135 and % APhCy CD21 positive cells, out of the doubly positive FE CD20/PerCF CD45 population over time, after injection of A1488 labeled HB135 (an anti-CR2 antibody, administration indicated by first arrow) followed by injection of rabbit anti-mouse IgG (administration indicated by the second arrow). FIGS. SC and SD are plots of the molecules of equivalent soluble fluorochome (MESF) values for these populations.

摘要翻译： 本发明涉及免疫复合物组合物，以及使用该复合物以增强针对预选靶抗原的血液免疫应答的方法。 本发明的免疫复合物包含对与靶抗原连接的B淋巴细胞上的补体受体（CR2）位点结合有特异性的单克隆抗体。 如图所示。 与猴B细胞结合的SA-SD免疫复合物与CR2的丧失一起被去除。 图 SA和SB在注射A1488标记的HB135（抗CR2抗体，由第一个箭头表示的给药）后，证明了在双倍阳性FE CD20 / PerCF CD45群体中随时间推移的％A1488 HB135和％APhCy CD21阳性细胞， 注射兔抗小鼠IgG（由第二个箭头表示的给药）。 图 SC和SD是这些种群的等效可溶性荧光素（MESF）值分子的图。

公开(公告)号：US5879679A

公开(公告)日：1999-03-09

申请号：US460861

申请日：1995-06-05

申请人： Ronald P. Taylor ,  Polly J. Ferguson ,  Edward N. Martin, Jr. ,  William M. Sutherland ,  Craig J. Reist ,  Kirsten Greene ,  Cyd Johnson

发明人： Ronald P. Taylor ,  Polly J. Ferguson ,  Edward N. Martin, Jr. ,  William M. Sutherland ,  Craig J. Reist ,  Kirsten Greene ,  Cyd Johnson

IPC分类号： C12N15/02 ,  A61K35/18 ,  A61K39/00 ,  A61K39/395 ,  A61K39/44 ,  A61K47/48 ,  A61P37/00 ,  C07K16/28 ,  C07K16/46 ,  C07K19/00 ,  C12P21/08 ,  C12R1/91 ,  C07K16/00

CPC分类号： C07K16/2896 ,  A61K39/0008 ,  A61K47/48561

摘要： Constructs consisting of antigen-based heteropolymers (AHP's) are provided. The antigen-based heteropolymers comprise at least one monoclonal antibody specific for binding to complement receptor (CR1) site on a human or non-human primate erythrocyte, and the anti-CR1 monoclonal antibody is crosslinked to an antigen specific for a target pathogenic autoantibody. Further provided is a method for treating autoimmune diseases in human or non-human primates using the AHP.

公开(公告)号：US06572856B1

公开(公告)日：2003-06-03

申请号：US09724620

申请日：2000-11-28

申请人： Ronald Taylor ,  Alessandra Nardin ,  William M. Sutherland ,  Mitchell H. Sokoloff ,  Leland Chung

发明人： Ronald Taylor ,  Alessandra Nardin ,  William M. Sutherland ,  Mitchell H. Sokoloff ,  Leland Chung

IPC分类号： A61K39395

CPC分类号： A61K39/395 ,  A61K38/00 ,  A61K48/00 ,  A61K51/1072 ,  C07K16/18 ,  C07K16/2896 ,  C07K16/3069 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2319/00 ,  A61K2300/00

摘要： The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also relates to methods of treating and preventing cancer, viral infection, or microbial infection in an animal comprising administering to said animal IgG antibodies, IgM antibodies and/or complement components in combination with antibodies specific for C3b(i). The present invention also relates methods of treating and preventing cancer, viral infection or microbial infection in an animal comprising administrating said animal antibodies that immunospecifically bind to one or more cancer cell antigens, viral antigens or microbial antigens, respectively, in combination with antibodies immunospecific for C3b(i). The present invention further relates to the detection, imaging, diagnosis and monitoring of cancer utilizing C3b(i) specific antibodies.

摘要翻译： 本发明涉及通过施用抗C3b（i）抗体来治疗和预防癌症，病毒感染和微生物感染。 本发明还涉及治疗和预防动物中的癌症，病毒感染或微生物感染的方法，包括向所述动物IgG抗体，IgM抗体和/或补体成分与C3b（i）特异的抗体组合施用。 本发明还涉及治疗和预防动物中的癌症，病毒感染或微生物感染的方法，其包括分别将免疫特异性结合一种或多种癌细胞抗原，病毒抗原或微生物抗原的所述动物抗体与免疫特异性抗体 C3b（i）。 本发明还涉及使用C3b（i）特异性抗体的癌症的检测，成像，诊断和监测。

公开(公告)号：US5470570A

公开(公告)日：1995-11-28

申请号：US161812

申请日：1993-12-06

申请人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

发明人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

IPC分类号： A61K35/18 ,  A61K38/00 ,  A61K47/48 ,  C07K16/28 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42

CPC分类号： A61K47/48561 ,  A61K35/18 ,  A61K47/48684 ,  A61K47/48776 ,  C07K16/28 ,  A61K38/00

摘要： Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.

摘要翻译： 哺乳动物红细胞用于通过与RBC结合在RBC上对于受体（CR1）特异性的单克隆抗体来安全地和快速地中和和/或清除来自循环系统的抗原或免疫原，该单克隆抗体与RBC化学结合 Mab具体针对从循环系统中清除的抗原。 这些化学交联的单克隆抗体杂聚物可以直接注射到患者的循环系统中。 或者，从患者提取或由合适的供体提供的红细胞与Mab复合物结合并返回到系统。

公开(公告)号：US5487890A

公开(公告)日：1996-01-30

申请号：US186136

申请日：1994-01-24

申请人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

发明人： Ronald P. Taylor ,  William M. Sutherland ,  Craig Reist ,  Eleanor L. Wright ,  Donna Webb ,  Ronald Labuguen

IPC分类号： A61K35/18 ,  A61K38/00 ,  A61K47/48 ,  C07K16/28 ,  A61K39/395 ,  A61K39/40 ,  A61K39/42

CPC分类号： A61K47/48561 ,  A61K35/18 ,  A61K47/48684 ,  A61K47/48776 ,  C07K16/28 ,  A61K38/00

摘要： Mammalian red blood cells are used to safely and rapidly neutralize and/or clear antigens or immunogens from the circulatory system by binding to the RBC a monoclonal antibody specific for a receptor (CR1) on the RBC, which monoclonal antibody is chemically bound to a second Mab specific for the antigen to be cleared from the circulatory system. These chemically cross-linked monoclonal antibody heteropolymers may be injected directly into the patient's circulatory system. Alternatively, red blood cells, extracted from the patient or provided by a suitable donor, are bound to the Mab complex and returned to the system.

公开(公告)号：US5047508A

公开(公告)日：1991-09-10

申请号：US42193

申请日：1987-04-21

申请人： John C. Herr ,  Mark Sigman ,  William M. Sutherland

发明人： John C. Herr ,  Mark Sigman ,  William M. Sutherland

IPC分类号： C07K16/18 ,  C12N5/20

CPC分类号： C07K16/18

摘要： A monoclonal antibody MHS-5 which specifically binds to a seminal vesicle specific antigen, SVSA, wherein the seminal vesicle specific antigen is secreted by the principal cells of the seminal vesicle epithelium. The method for producing this monoclonal antibody is also disclosed.

摘要翻译： 特异性结合精囊特异性抗原SVSA的单克隆抗体MHS-5，其中精囊细胞特异性抗原由精囊上皮的主要细胞分泌。 还公开了该单克隆抗体的制备方法。

公开(公告)号：US4741998A

公开(公告)日：1988-05-03

申请号：US741601

申请日：1985-06-05

申请人： John C. Herr ,  Mark Sigman ,  William M. Sutherland

发明人： John C. Herr ,  Mark Sigman ,  William M. Sutherland

IPC分类号： G01N33/53 ,  C07K1/22 ,  C07K14/005 ,  C07K14/195 ,  C07K16/00 ,  C07K16/18 ,  C12N5/00 ,  C12N5/10 ,  C12N15/00 ,  C12P21/00 ,  C12P21/08 ,  C12R1/91 ,  G01N33/577 ,  C07K15/00 ,  G01N33/535

CPC分类号： C07K16/18 ,  Y10S435/81 ,  Y10S435/948 ,  Y10S435/975 ,  Y10S436/808

摘要： A new probe for forensic analysis of sexual assaults is disclosed. The probe is a monoclonal antibody to a new protein marker, MHS-5, in semen. Also disclosed is the hybridoma producing the antibody as well as an assay utilizing the antibody for forensic analysis of criminal evidence.

摘要翻译： 披露了一项关于性攻击法医分析的新探索。 探针是针对新的蛋白质标记物MHS-5在精液中的单克隆抗体。 还公开了产生抗体的杂交瘤以及利用该抗体进行刑事证据法医分析的试验。

公开(公告)号：US1976573A

公开(公告)日：1934-10-09

申请号：US68390633

申请日：1933-08-05

申请人： WILLIAM M SUTHERLAND ,  NEIL W SNOW

发明人： RAY MACDONALD WALTER

IPC分类号： C04B20/06

CPC分类号： C04B20/068 ,  Y10S264/39 ,  C04B14/08