公开(公告)号：US20100015148A1

公开(公告)日：2010-01-21

申请号：US12343063

申请日：2008-12-23

申请人： Leland W. K. Chung ,  Wen-Chin Huang ,  Valerie Odero-Marah ,  Daqing Wu ,  Chia-Ling Hsieh ,  Haiyen Zhau

发明人： Leland W. K. Chung ,  Wen-Chin Huang ,  Valerie Odero-Marah ,  Daqing Wu ,  Chia-Ling Hsieh ,  Haiyen Zhau

IPC分类号： A61K39/395 ,  C12N5/02 ,  A61K31/7088 ,  C12Q1/68

CPC分类号： G01N33/5011 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/2833 ,  C07K2317/73 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886

摘要： A method for interfering with osteomimetic properties of a cell includes introducing into the cell an osteomimecry-interfering compound, wherein said osteomimecry-interfering compound prevents or ameliorates the expression of the osteomimetic properties of said cell. A method for treating or ameliorating an osteotropic-related cancer or disorder in a subject includes administering to the subject an osteomimecry interfering compound. A method for identifying a compound that modulates the osteomimetic potential of a cell includes contacting a cell exhibiting osteomimetic potential with a test compound; measuring expression levels of one or more osteomimetic gene products in the cell in the presence and in the absence of the test compound; and identifying a compound that modulates the osteomimetic potential, wherein the compound changes the expression levels of one or more osteomimetic gene products in the cell.

摘要翻译： 用于干扰细胞的骨模拟性质的方法包括向细胞中引入骨干哺乳干扰化合物，其中所述骨修复干扰化合物预防或改善所述细胞的骨模拟性质的表达。 用于治疗或改善受试者中的骨相关性癌症或病症的方法包括向受试者施用骨前体干扰化合物。 用于鉴定调节细胞的骨模拟潜力的化合物的方法包括使表现出骨骼发展潜力的细胞与测试化合物接触; 在存在和不存在测试化合物的情况下测量细胞中一种或多种骨模拟基因产物的表达水平; 以及鉴定调节所述骨模拟潜力的化合物，其中所述化合物改变所述细胞中一种或多种成骨细胞基因产物的表达水平。

公开(公告)号：US20070078085A1

公开(公告)日：2007-04-05

申请号：US11248337

申请日：2005-10-13

申请人： Leland Chung ,  Wen-Chin Huang ,  Valerie Odero-Marah ,  Daqing Wu ,  Chia-Ling Hsieh ,  Haiyen Zhau

发明人： Leland Chung ,  Wen-Chin Huang ,  Valerie Odero-Marah ,  Daqing Wu ,  Chia-Ling Hsieh ,  Haiyen Zhau

IPC分类号： A61K48/00 ,  A61K38/18 ,  C12Q1/68 ,  G01N33/574

CPC分类号： A61K31/70 ,  A61K48/00 ,  C07K16/22 ,  C07K16/2833 ,  C07K2317/76 ,  C12N15/113 ,  C12N2310/14 ,  C12Q1/6886 ,  G01N33/5011

摘要： The present invention relates to compositions and methods for modulating osteomimicry within tumor and tissue cells with calcification potential. The invention further relates to screening compounds that modulate osteomimicry within tumor and tissue cells with calcification potential. Methods for using compounds identified by the screening assays for therapeutic treatments also are provided. The invention further relates to methods of treating those tumors and other diseases and disorders with calcification potential with compounds that modulate their osteomimetic potential.

摘要翻译： 本发明涉及在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的组合物和方法。 本发明进一步涉及筛选在具有钙化潜能的肿瘤和组织细胞内调节骨肉瘤的化合物。 还提供了通过筛选测定法鉴定的化合物用于治疗性治疗的方法。 本发明还涉及用调节其骨骼模拟潜能的化合物治疗具有钙化潜能的那些肿瘤和其它疾病和病症的方法。