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    Preparations of phospholipids and pharmaceuticals containing 5-amino salicylic acid for the treatment of inflammatory bowel disease
    4.
    发明申请
    Preparations of phospholipids and pharmaceuticals containing 5-amino salicylic acid for the treatment of inflammatory bowel disease 失效
    含有5-氨基水杨酸的磷脂和药物的制备用于治疗炎症性肠病

    公开(公告)号：US20080020056A1

    公开(公告)日：2008-01-24

    申请号：US11880059

    申请日：2007-07-19

    申请人： Lenard Lichtenberger

    发明人： Lenard Lichtenberger

    IPC分类号： A61K9/58 ,  A61K31/685 ,  A61P1/06 ,  C07F9/10

    CPC分类号： C07F9/106 ,  A61K9/127 ,  A61K31/606

    摘要： A unique composition of a 5-amino salicylic acid (5ASA) and a phospholipid is disclosed for treating Inflammatory Bowel Disease (IBD), where the composition can be a mixture, a molecular association complex or a covalent compound of 5ASA and a reactive phospholipid covalently bonded together via a diazo linkage and to methods for administering the compositions to treat symptoms of IBD.

    摘要翻译： 公开了5-氨基水杨酸（5ASA）和磷脂的独特组合物，用于治疗炎症性肠病（IBD），其中组合物可以是5ASA和分子缔合复合物或5ASA的共价化合物和共价反应性磷脂 通过重氮连接键合在一起，以及用于施用组合物以治疗IBD症状的方法。

    Parenteral preparations of GI-safer phospholipid-associated anti-inflammatories and methods of preparation and use
    5.
    发明申请
    Parenteral preparations of GI-safer phospholipid-associated anti-inflammatories and methods of preparation and use 审中-公开
    胃肠外制剂治疗更安全的磷脂相关抗炎药及其制备和使用方法

    公开(公告)号：US20080051373A1

    公开(公告)日：2008-02-28

    申请号：US11881058

    申请日：2007-07-25

    申请人： Lenard Lichtenberger ,  Elizabeth Dial

    发明人： Lenard Lichtenberger ,  Elizabeth Dial

    IPC分类号： A61K31/662 ,  A61P43/00 ,  A61P9/00

    CPC分类号： A61K31/662 ,  A61K9/0019

    摘要： Parenteral preparations of phospholipid-associated anti-inflammatories (PL-AIs) are described to treat pain/inflammation, with reduced gastrointestinal (GI) toxicity. The PL-AIs can be composed of phosphatidylcholine (“PC”) associated with non-steroidal anti-inflammatory drugs (“NSAIDs”). To prepare the PL-AIs, a phospholipid is mixed with an NSAID in a polar solvent, solvent is removed, suspended in an aqueous medium and sterilized by filtration or other acceptable method. Alternatively, the phospholipid can be mixed with an injectable preparation of an NSAID. The PL-AIs, and particularly PC associated with the NSAIDs, indomethacin, ibuprofen or diclofenac are useful for treating Patent Ductus Arteriosus in low birth weight infants to reduce the incidence of GI injury that may be manifest as Necrotizing Enterocolitis (NEC) or Spontaneous Intestinal Perforation (SIP). Other applications of the parenteral PL-AIs include prevention of: retinopathy of prematurity; and of pain from conditions associated with surgery, trauma, Sickle Cell Anemia and neural inflammation/injury.

    摘要翻译： 描述了磷脂相关抗炎药（PL-AI）的肠胃外制剂治疗疼痛/炎症，消化道（GI）毒性降低。 PL-AI可以由与非甾体抗炎药（“NSAID”）相关的磷脂酰胆碱（“PC”）组成。 为了制备PL-AI，将磷脂与极性溶剂中的NSAID混合，除去溶剂，悬浮在水性介质中并通过过滤或其它可接受的方法灭菌。 或者，磷脂可与NSAID的可注射制剂混合。 与NSAIDs，吲哚美辛，布洛芬或双氯芬酸相关的PL-AIs，特别是PC可用于治疗低出生体重儿的专利导管动脉瘤，以减少可能表现为坏死性坏死性肠球菌炎（NEC）或自发肠道 穿孔（SIP）。 肠外PL-AI的其他应用包括预防：早产儿视网膜病变; 和与手术，创伤，镰状细胞性贫血和神经炎症/损伤相关的疾病的疼痛。

    Sterile preparations of phospholipids and anti-inflammatory pharmaceuticals and methods for making and using same
    6.
    发明申请
    Sterile preparations of phospholipids and anti-inflammatory pharmaceuticals and methods for making and using same 审中-公开
    磷脂和抗炎药物的无菌制剂及其制备和使用方法

    公开(公告)号：US20050058699A1

    公开(公告)日：2005-03-17

    申请号：US10909748

    申请日：2004-08-02

    申请人： Lenard Lichtenberger ,  Elizabeth Dial

    发明人： Lenard Lichtenberger ,  Elizabeth Dial

    IPC分类号： A61K20060101 ,  A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/0019 ,  A61K47/24

    摘要： A filter sterilized composition of a phospholipid and an anti-inflammatory pharmaceutical is disclosed, where the anti-inflammatory pharmaceutical is a nonsteroidal, anti-inflammatory drug (NSAID), a cyclooxygenase 2 (COX-2) inhibitor or a mixture thereof. A method for preparing these sterile compositions is also disclosed and includes a filtration step through a sterilizing filtration membrane. Methods for using these sterilized compositions to treat accident and battle field injuries or treatment of injuries to the nerve system especially in unconscious patients via injection, topical administration, or according to an administration protocol.

    摘要翻译： 公开了一种过滤灭菌的磷脂和抗炎药物组合物，其中抗炎药物是非甾体抗炎药（NSAID），环氧合酶2（COX-2）抑制剂或其混合物。 还公开了制备这些无菌组合物的方法，并且包括通过灭菌过滤膜的过滤步骤。 使用这些无菌组合物来治疗事故和战场伤害或治疗神经系统特别是无意识患者的注射，局部给药或根据给药方案的方法。