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    SYSTEMS AND METHODS FOR DELIVERY OF PEPTIDES
    3.
    发明申请
    SYSTEMS AND METHODS FOR DELIVERY OF PEPTIDES 有权
    用于递送肽的系统和方法

    公开(公告)号：US20160158279A1

    公开(公告)日：2016-06-09

    申请号：US15041616

    申请日：2016-02-11

    申请人： Transdermal Biotechnology, Inc.

    发明人： Nicholas V. Perricone

    IPC分类号： A61K33/00 ,  A61K9/06 ,  A61K47/48 ,  A61K9/00 ,  A61K38/00

    CPC分类号： A61K33/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K9/127 ,  A61K38/00 ,  A61K38/06 ,  A61K38/066 ,  A61K38/11 ,  A61K38/2271 ,  A61K38/28 ,  A61K38/34 ,  A61K47/48053 ,  A61K47/544 ,  A61K2300/00

    摘要： The present invention generally relates to compositions and methods for topical or transdermal delivery. The compositions can be used in a variety of applications. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. The composition can also be applied to a mucosal surface in some instances. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

    摘要翻译： 本发明一般涉及用于局部或透皮递送的组合物和方法。 组合物可用于各种应用。 在一些情况下，组合物可以包括一氧化氮和/或肽。 一氧化氮和/或肽可以存在于包含卵磷脂（例如磷脂酰胆碱）的第一相内。 在某些实施方案中，卵磷脂存在于含有一氧化氮，肽或两者的脂质体，胶束或其它囊泡中。 组合物可以采用可以被摩擦或喷到皮肤上的凝胶，乳膏，洗剂，软膏，溶液，固体“棒”等的形式。 在某些情况下，该组合物也可用于粘膜表面。 本发明的其它方面一般涉及制备或使用这种组合物的方法，促进这种组合物的方法，包括这种组合物的试剂盒等。

    IMMUNE MODULATION USING PEPTIDES AND OTHER COMPOSITIONS
    4.
    发明申请
    IMMUNE MODULATION USING PEPTIDES AND OTHER COMPOSITIONS 有权
    使用肽和其他组合物进行免疫调节

    公开(公告)号：US20160158277A1

    公开(公告)日：2016-06-09

    申请号：US15041282

    申请日：2016-02-11

    申请人： Transdermal Biotechnology, Inc.

    发明人： Nicholas V. Perricone

    IPC分类号： A61K33/00 ,  A61K9/06 ,  A61K47/48 ,  A61K38/06 ,  A61K9/00

    CPC分类号： A61K33/00 ,  A61K9/0014 ,  A61K9/06 ,  A61K38/066 ,  A61K38/34 ,  A61K39/00 ,  A61K47/10 ,  A61K47/14 ,  A61K47/24 ,  A61K47/48053 ,  A61K47/544 ,  A61K2300/00

    摘要： The present invention generally relates to compositions and methods for topical or transdermal delivery for immune modulation. In some cases, the composition may include nitric oxide and/or peptides. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present in liposomes, micelles, or other vesicles containing nitric oxide, peptides, or both. The composition can take the form of a gel, a cream, a lotion, an ointment, a solution, a solid “stick,” etc., that can be rubbed or sprayed onto the skin. Other aspects of the present invention are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.

    摘要翻译： 本发明一般涉及用于免疫调节的局部或透皮递送的组合物和方法。 在一些情况下，组合物可以包括一氧化氮和/或肽。 一氧化氮和/或肽可以存在于包含卵磷脂（例如磷脂酰胆碱）的第一相内。 在某些实施方案中，卵磷脂存在于含有一氧化氮，肽或两者的脂质体，胶束或其它囊泡中。 组合物可以采用可以被摩擦或喷到皮肤上的凝胶，乳膏，洗剂，软膏，溶液，固体“棒”等的形式。 本发明的其它方面一般涉及制备或使用这种组合物的方法，促进这种组合物的方法，包括这种组合物的试剂盒等。

    Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies
    8.
    发明授权
    Immunogenic composites capable of stimulating production of anti-peptide antibodies, pharmaceutical compositions employing these composites and methods of selectively inducing production of anti-peptide antibodies 失效
    能够刺激抗肽抗体产生的免疫原性复合物，采用这些复合材料的药物组合物和选择性诱导抗肽抗体产生的方法

    公开(公告)号：US6048531A

    公开(公告)日：2000-04-11

    申请号：US160093

    申请日：1993-12-01

    申请人： Raphael James Mannino ,  Gail Goodman-Snitkoff

    发明人： Raphael James Mannino ,  Gail Goodman-Snitkoff

    IPC分类号： A61K39/21 ,  A61K39/385 ,  A61K47/48 ,  A61P37/04 ,  C07K17/06

    CPC分类号： A61K47/4833 ,  A61K39/12 ,  A61K39/21 ,  A61K39/385 ,  A61K47/48023 ,  A61K47/48053 ,  A61K2039/57 ,  A61K2039/6018 ,  C12N2740/16134

    摘要： An essentially pure immunogenic composite capable of selectively inducing antibody production in an animal to a peptide that if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate production of anti-peptide antibody in the animal. This immunogenic composite comprises: a lipid and an amphipathic peptide. The amphipathic peptide if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate production of anti-peptide antibody in the animal. The amphipathic peptide is covalently bound to the lipid in a peptide-lipid complex. The immunogenic composite has a vesicular or an amorphous particulate structure. Another embodiment of this immunogenic composite comprises: a lipid, the amphipathic peptide, and a hydrophilic peptide covalently bound together. The hydrophilic peptide if administered by itself to the animal without being conjugated to or mixed with additional substance does not stimulate production of anti-peptide antibody in the animal.

    摘要翻译： 能够选择性地诱导动物体内产生抗体的肽基本上纯的免疫原性复合物，如果将其自身施用于动物而不与另外的物质偶联或混合，则其不会刺激动物中抗肽抗体的产生。 该免疫原性复合物包含：脂质和两亲性肽。 两亲肽如果自身施用于动物而不与另外的物质缀合或混合，则不会刺激动物中抗肽抗体的产生。 两亲肽在肽 - 脂质复合物中与脂质共价结合。 免疫原性复合物具有囊泡或无定形颗粒结构。 该免疫原性复合物的另一个实施方案包括：脂质，两亲肽和共价结合在一起的亲水肽。 亲水性肽如果自身给予动物而不与另外的物质缀合或混合，则不刺激动物中抗肽抗体的产生。