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    D-Homopregnanes
    1.
    发明授权
    D-Homopregnanes 失效

    公开(公告)号：US4202841A

    公开(公告)日：1980-05-13

    申请号：US973336

    申请日：1978-12-26

    申请人： Leo Alig ,  Andor Furst ,  Marcel Muller ,  Ulrich Kerb ,  Klaus Kieslich ,  Rudolf Wiechert

    发明人： Leo Alig ,  Andor Furst ,  Marcel Muller ,  Ulrich Kerb ,  Klaus Kieslich ,  Rudolf Wiechert

    IPC分类号： C07J63/00 ,  C12P33/02 ,  C12P33/08 ,  C07C49/00

    CPC分类号： C07J63/008 ,  C12P33/02 ,  C12P33/08

    摘要： D-Homopregnanes of the formula ##STR1## wherein the dotted line in the 1,2-position together with the corresponding solid line denotes a single or double carbon-carbon bond; R.sup.6 is hydrogen, fluoro, chloro or methyl; R.sup.9 is hydrogen, fluoro, chloro or bromo; R.sup.11 is hydroxyl, acyloxy, fluoro or chloro; and R.sup.17a is hydroxyl or acyloxy with the proviso that when R.sup.9 is fluoro, chloro or bromo and R.sup.11 is fluoro or chloro, the atomic number of R.sup.11 is less than or equal to that of R.sup.9 ; and with the further proviso that when R.sup.6 is hydrogen, and R.sup.11 and R.sup.17a are hydroxy or when R.sup.6 is fluoro, R.sup.11 and R.sup.17a are hydroxyl and the dotted line in the 1,2-position together with the corresponding solid line denotes a single carbon-carbon bond, R.sup.9 is fluoro, chloro or bromo and processes for the preparation thereof are disclosed.

    摘要翻译： 式Ⅰ的D-homopregnanes其中1,2位虚线连同相应实线表示单碳双键; R6是氢，氟，氯或甲基; R9是氢，氟，氯或溴; R11是羟基，酰氧基，氟或氯; 并且R 17a是羟基或酰氧基，条件是当R 9是氟时，氯或溴，R 11是氟或氯，R 11的原子数小于或等于R 9的原子数; 并且进一步的条件是当R6为氢时，R11和R17a为羟基或当R6为氟时，R11和R17a为羟基，1,2-位与虚线相应的实线表示单个碳 - 碳键，R9是氟，氯或溴，并且其制备方法被公开。

    D-homopregnanes
    4.
    发明授权
    D-homopregnanes 失效
    D-己内酯

    公开(公告)号：US4131655A

    公开(公告)日：1978-12-26

    申请号：US898070

    申请日：1978-04-20

    申请人： Leo Alig ,  Andor Furst ,  Marcel Muller ,  Ulrich Kerb ,  Rudolf Wiechert

    发明人： Leo Alig ,  Andor Furst ,  Marcel Muller ,  Ulrich Kerb ,  Rudolf Wiechert

    IPC分类号： A61K31/12 ,  A61K31/215 ,  A61K31/22 ,  A61K31/57 ,  A61P29/00 ,  C07J63/00 ,  C07F9/09 ,  C07C49/44

    CPC分类号： C07J63/008

    摘要： D-homopregnanes of the formula ##STR1## wherein R.sup.6 is hydrogen, chloro, fluoro or methyl; X is .beta.-hydroxymethylene or carbonyl; R.sup.17a is hydroxy, lower alkanoyloxy or aroyloxy; R.sup.21 is hydrogen, chloro, fluoro, hydroxy, lower alkanoyloxy, aroyloxy, sulfate or phosphate; and the dotted line in the 1,2-position of the A-ring denotes an additional carbon-carbon bondAnd pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them as the active ingredient are disclosed. The D-homopregnanes of the present invention exhibit hormonal activity and are useful for the treatment of inflammation.

    摘要翻译： 其中R6是氢，氯，氟或甲基的式XI的D-己内酯; X是β-羟基亚甲基或羰基; R17a是羟基，低级烷酰氧基或芳酰氧基; R21是氢，氯，氟，羟基，低级烷酰氧基，芳氧基，硫酸根或磷酸根; A环的1,2位的虚线表示另外的碳 - 碳键，并且其药学上可接受的盐，其制备方法和作为活性成分的药物组合物被公开。 本发明的D-己内酯具有激素活性，可用于治疗炎症。