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    MULTIPARAMETER ANALYSIS FOR DRUG RESPONSE AND RELATED METHODS
    1.
    发明申请
    MULTIPARAMETER ANALYSIS FOR DRUG RESPONSE AND RELATED METHODS 审中-公开
    多药物反应分析及相关方法

    公开(公告)号：US20080131905A1

    公开(公告)日：2008-06-05

    申请号：US12019600

    申请日：2008-01-24

    申请人： Leroy E. Hood ,  Andrew F. Siegel

    发明人： Leroy E. Hood ,  Andrew F. Siegel

    IPC分类号： C12Q1/68 ,  C12Q1/70 ,  C12Q1/20

    CPC分类号： G16B40/00 ,  G16B25/00

    摘要： The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within the health-associated reference expression region indicate a reference expression profile and wherein expression levels outside the health-associated reference expression region indicate a perturbed expression profile. The invention also provides methods of diagnosing a disease or a health state in an individual by comparing the expression level of a sample of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules. The invention additionally provides a method of classifying a population by drug responsiveness.

    摘要翻译： 本发明提供了一种通过将来自个体的标本中的分子群体中的分子样品与分子样品的健康相关参考表达区域的分子样品的表达水平进行比较来确定个体中比较表达谱的方法，其中 健康相关参考表达区域内的表达水平指示参考表达谱，并且其中健康相关参考表达区域之外的表达水平表示扰动的表达谱。 本发明还提供了通过比较来自个体的样品中的分子样品与分子样品的健康相关参考表达区域的表达水平来诊断个体中疾病或健康状态的方法。 本发明另外提供了通过药物反应性对群体进行分类的方法。

    Methods of classifying drug responsiveness using multiparameter analysis
    2.
    发明授权
    Methods of classifying drug responsiveness using multiparameter analysis 有权
    使用多参数分析对药物反应性进行分类的方法

    公开(公告)号：US07343247B2

    公开(公告)日：2008-03-11

    申请号：US09919360

    申请日：2001-07-30

    申请人： Leroy E. Hood ,  Andrew F. Siegel

    发明人： Leroy E. Hood ,  Andrew F. Siegel

    IPC分类号： G01N33/48 ,  G06G7/48 ,  C12Q1/68

    CPC分类号： G06F19/24 ,  G06F19/20

    摘要： The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within the health-associated reference expression region indicate a reference expression profile and wherein expression levels outside the health-associated reference expression region indicate a perturbed expression profile. The invention also provides methods of diagnosing a disease or a health state in an individual by comparing the expression level of a sample of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules. The invention additionally provides a method of classifying a population by drug responsiveness.

    摘要翻译： 本发明提供了一种通过将来自个体的标本中的分子群体中的分子样品与分子样品的健康相关参考表达区域的分子样品的表达水平进行比较来确定个体中比较表达谱的方法，其中 健康相关参考表达区域内的表达水平指示参考表达谱，并且其中健康相关参考表达区域之外的表达水平表示扰动的表达谱。 本发明还提供了通过比较来自个体的样品中的分子样品与分子样品的健康相关参考表达区域的表达水平来诊断个体中疾病或健康状态的方法。 本发明另外提供了通过药物反应性对群体进行分类的方法。

    Gene discovery for the system assignment of gene function
    3.
    发明授权
    Gene discovery for the system assignment of gene function 有权
    基因功能系统分配的基因发现

    公开(公告)号：US07623969B2

    公开(公告)日：2009-11-24

    申请号：US10062299

    申请日：2002-01-31

    申请人： Leroy E. Hood ,  Andrew F. Siegel ,  Trey E. Ideker

    发明人： Leroy E. Hood ,  Andrew F. Siegel ,  Trey E. Ideker

    IPC分类号： G01N33/48

    CPC分类号： G06F19/18 ,  Y10S707/99943

    摘要： The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more components of a biochemical system in a reference state; (b) perturbing a component within said biochemical system; (c) determining a perturbed multidimensional shape space for one or more components of a pathway in said perturbed biochemical system, and (d) identifying a multidimensional coordinate point corresponding to a component of said perturbed pathway altered between reference and perturbed multidimensional shape spaces, said identified component being assigned a cellular function of said perturbed pathway.

    摘要翻译： 本发明提供了一种将细胞功能分配给生化系统的组分的方法。 该方法包括（a）确定参考状态下生物化学系统的一个或多个组分的多维形状空间; （b）扰乱所述生化系统内的组分; （c）确定所述扰动的生物化学系统中的一个或多个组分的扰动多维形状空间，以及（d）识别对应于在参考和扰动的多维形状空间之间改变的所述扰动路径的分量的多维坐标点，所述多维坐标点 所识别的组分被分配有所述扰动途径的细胞功能。

    Acoustically controlled substance delivery device
    6.
    发明授权
    Acoustically controlled substance delivery device 有权
    声控物质输送装置

    公开(公告)号：US08083710B2

    公开(公告)日：2011-12-27

    申请号：US12217872

    申请日：2008-07-08

    申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

    发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K. Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood

    IPC分类号： A61M1/00 ,  A61K9/22

    CPC分类号： A61M37/0092

    摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.

    摘要翻译： 描述了包括远程控制物质输送装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，输送装置或相关装置可以放置在环境中以便将材料泵入环境或设备内的附加流体处理结构。 示例性环境包括生物体，水体或封闭体积的流体。 被输送流体中物质的浓度可以通过遥控信号来改变。 在所选择的实施例中，可以使用声控制信号。

    Beverage Immersate with detection capability
    7.
    发明申请
    Beverage Immersate with detection capability 有权
    饮料浸入具有检测能力

    公开(公告)号：US20110053283A1

    公开(公告)日：2011-03-03

    申请号：US12584054

    申请日：2009-08-28

    申请人： Leroy E. Hood ,  Edward K.Y. Jung ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, JR.

    发明人： Leroy E. Hood ,  Edward K.Y. Jung ,  Elizabeth A. Sweeney ,  Clarence T. Tegreene ,  Lowell L. Wood, JR.

    IPC分类号： G01N33/14 ,  G01N31/00 ,  G01N33/00

    CPC分类号： A61B5/0002 ,  A61B5/00 ,  A61B5/411 ,  G01N33/14 ,  G06F19/00 ,  G06Q50/24 ,  Y02A90/22 ,  Y02A90/26 ,  Y10T436/163333

    摘要： Methods and systems described herein include beverage immersates and methods of their use. Systems include: at least one beverage immersate, wherein the at least one beverage immersate includes at least one sensor configured to detect at least one analyte in a fluid within a personal use beverage container; and at least one signal transmitter configured to transmit a signal responsive to the at least one beverage immersate. Methods include: detecting one or more analyte in fluid within a personal use beverage container with at least one sensor integral to at least one beverage immersate; and communicating data from the at least one beverage immersate to at least one device external to the beverage immersate.

    摘要翻译： 本文所述的方法和系统包括饮料浸渍及其使用方法。 系统包括：至少一种饮料浸泡，其中所述至少一种饮料浸入物包括至少一个传感器，所述传感器被配置为检测个人使用饮料容器内的流体中的至少一种分析物; 以及至少一个信号发射器，被配置为响应于所述至少一个饮料浸没而传输信号。 方法包括：在个人使用的饮料容器内检测流体中的一种或多种分析物，其中至少一个传感器与至少一种饮料浸入一体; 以及将来自所述至少一个饮料的数据传送到所述饮料外部的至少一个装置，所述装置浸没。

    Acoustically controlled substance delivery device
    9.
    发明申请
    Acoustically controlled substance delivery device 有权
    声控物质输送装置

    公开(公告)号：US20090005727A1

    公开(公告)日：2009-01-01

    申请号：US12217872

    申请日：2008-07-08

    申请人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    发明人： Leroy E. Hood ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Clarence T. Tegreene ,  Lowell L. Wood, JR. ,  Victoria Y.H. Wood

    IPC分类号： A61M1/00

    CPC分类号： A61M37/0092

    摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.

    摘要翻译： 描述了包括远程控制物质输送装置和相关控制器的系统的实施例。 还公开了装置的使用和控制方法。 根据一些实施例，输送装置或相关装置可以放置在环境中以便将材料泵入环境或装置内的附加流体处理结构。 示例性环境包括生物体，水体或封闭体积的流体。 被输送流体中物质的浓度可以通过遥控信号来改变。 在所选择的实施例中，可以使用声控制信号。