Method for increasing bioavailability of orally administered
pharmaceutical compounds
    1.
    发明授权
    Method for increasing bioavailability of orally administered pharmaceutical compounds 失效
    提高口服药物化合物生物利用度的方法

    公开(公告)号:US6004927A

    公开(公告)日:1999-12-21

    申请号:US462757

    申请日:1995-06-05

    摘要: A method for increasing bioavailability of an orally administered hydrophobic pharmaceutical compound, which comprises orally administering the pharmaceutical compound to a mammal in need of treatment with the compound concurrently with a bioenhancer comprising an inhibitor of a cytochrome P450 3A enzyme or an inhibitor of P-glycoprotein-mediated membrane transport, the bioenhancer being present in sufficient amount to provide bioavailability of the compound in the presence of the bioenhancer greater than the bioavailability of the compound in the absence of the bioenhancer.

    摘要翻译: 一种用于提高口服给药的疏水性药物化合物的生物利用度的方法,其包括将药物化合物口服施用于需要与化合物一起治疗的哺乳动物,所述生物降解剂包含细胞色素P450 3A酶抑制剂或P-糖蛋白抑制剂 介导的膜转运,所述生物增殖剂以足够的量存在,以在生物催化剂存在下提供化合物的生物利用度大于在不存在生物催化剂的情况下化合物的生物利用度。

    Method for increasing bioavailability of oral pharmaceutical compositions
    2.
    发明授权
    Method for increasing bioavailability of oral pharmaceutical compositions 失效
    提高口服药物组合物生物利用度的方法

    公开(公告)号:US6028054A

    公开(公告)日:2000-02-22

    申请号:US73704

    申请日:1998-05-06

    摘要: A method for increasing bioavailability of an orally administered hydrophobic pharmaceutical compound, which comprises orally administering the pharmaceutical compound to a mammal in need of treatment with the compound concurrently with a bioenhancer comprising an inhibitor of a cytochrome P450 3A enzyme or an inhibitor of P-glycoprotein-mediated membrane transport, the bioenhancer being present in sufficient amount to provide bioavailability of the compound in the presence of the bioenhancer greater than the bioavailability of the compound in the absence of the bioenhancer.

    摘要翻译: 一种用于提高口服给药的疏水性药物化合物的生物利用度的方法,其包括将药物化合物口服施用于需要与化合物一起治疗的哺乳动物,所述生物降解剂包含细胞色素P450 3A酶抑制剂或P-糖蛋白抑制剂 介导的膜转运,所述生物增殖剂以足够的量存在,以在生物催化剂存在下提供化合物的生物利用度大于在不存在生物催化剂的情况下化合物的生物利用度。

    Repairable TFT-LCD assembly and method for making in which a separation tape positioned between two anisotropic conductive films
    3.
    发明授权
    Repairable TFT-LCD assembly and method for making in which a separation tape positioned between two anisotropic conductive films 失效
    可修复的TFT-LCD组件及其制造方法,其中分离带位于两个各向异性导电膜之间

    公开(公告)号:US06373545B1

    公开(公告)日:2002-04-16

    申请号:US09274587

    申请日:1999-03-23

    IPC分类号: G02F11345

    CPC分类号: G02F1/13452 G02F1/1309

    摘要: A repairable TFT-LCD assembly and a method for fabricating such assembly have been disclosed. In the repairable TFT-LCD assembly, a novel separation tape is utilized between the TFT and the LCD substrate such that when the tape is pulled in a perpendicular direction to the planar surface of the LCD substrate, the TFT can be separated from the assembly without causing damages to the LCD substrate. The separation tape is fabricated of a polymeric based insulating material with a multiplicity of apertures filled with a conductive metal. The back of the separation tape is laminated with a copper film which is patterned corresponding to the pattern of conductive pads provided on the LCD substrate. The present invention is further directed to a method for fabricating the separation tape for use in a repairable TFT-LCD assembly.

    摘要翻译: 已经公开了一种可修复的TFT-LCD组件及其制造方法。 在可修复的TFT-LCD组件中,在TFT和LCD基板之间使用新的分离带,使得当沿与LCD基板的平面垂直的方向拉动带时,TFT可以与组件分离而没有 造成LCD基板损坏。 分离带由具有填充有导电金属的多个孔的聚合物基绝缘材料制成。 分离带的背面层叠有铜膜,该铜膜对应于设置在LCD基板上的导电焊盘的图案而被图案化。 本发明还涉及一种制造用于可修理TFT-LCD组件的分离带的方法。