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公开(公告)号：US5401730A
公开(公告)日：1995-03-28
申请号：US52219
申请日：1993-04-22
CPC分类号： A61K31/60 , A61K31/51 , A61K31/621 , A61K33/30 , Y10S514/822
摘要： Patients having a predisposition for thrombus formation are effectively treated with compositions of acetylsalicylic acid, citric acid, thiamine and/or a zinc salt. The combination of aspirin and citric acid has been found to be significantly more effective in inhibiting platelet aggregability than aspirin alone, and thiamine contributes to the reduction in thrombotic potential by reducing plasma fibrinogen levels. Accordingly, new methods and compositions are disclosed for reducing the thrombotic potential of human or animal subjects, such as in the prophylaxis or treatment of atherosclerosis, vascular surgery patients or other cardiovascular diseases.
摘要翻译： 具有血栓形成倾向的患者用乙酰水杨酸，柠檬酸，硫胺素和/或锌盐的组合物有效地治疗。 已经发现阿司匹林和柠檬酸的组合在单独使用阿司匹林抑制血小板聚集性方面显着更有效，硫胺素通过降低血浆纤维蛋白原水平有助于降低血栓形成潜力。 因此，公开了用于降低人或动物受试者的血栓形成潜力的新方法和组合物，例如预防或治疗动脉粥样硬化，血管外科手术患者或其它心血管疾病。
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公开(公告)号：US4911713A
公开(公告)日：1990-03-27
申请号：US7369
申请日：1987-01-27
申请人： Lester R. Sauvage , Svetlana Kaplan
发明人： Lester R. Sauvage , Svetlana Kaplan
CPC分类号： A61F2/062 , A61L27/22 , A61L27/34 , Y10S623/901 , Y10S623/921
摘要： A method of making an impermeable vascular prosthesis is disclosed which comprises the steps of treating a porous textile conduit with a first solution of cross-linking agent; perfusing the conduit with a second solution of cross-linking agent and protein; and drying the perfused conduit to allow gelation in a second solution to form an impermeable vascular prosthesis. Perfusion of the lumen of the prosthesis is performed with sufficient pressure to ensure that all interstices of the porous textile conduit are completely filled. A gelation mixture comprising albumin and glutaraldehyde is preferably utilized for perfusion of the prosthesis. Methods for preserving these grafts indefinitely by treatment with glycerol and other alkyl alcohols are also disclosed.
摘要翻译： 公开了一种制造不可渗透的血管假体的方法，其包括用第一交联剂溶液处理多孔织物导管的步骤; 用第二种交联剂和蛋白质溶液灌注导管; 并干燥灌注导管以允许在第二溶液中凝胶化以形成不可渗透的血管假体。 用足够的压力进行假体腔的灌注，以确保多孔织物导管的所有空隙完全充满。 包含白蛋白和戊二醛的凝胶化混合物优选用于假体的灌注。 还公开了通过用甘油和其它烷基醇处理无限期地保存这些移植物的方法。
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