公开(公告)号：US10076660B2

公开(公告)日：2018-09-18

申请号：US15382399

申请日：2016-12-16

申请人： The University of Dundee ,  The University of Abertay ,  University Court of the University of St. Andrews

发明人： Nigel Pitts ,  Christopher Longbottom ,  Joseph Crayston ,  Dmitri Grinev ,  Iain McEwing Young

IPC分类号： A61N1/32 ,  A61C19/06 ,  A61K8/19 ,  A61N1/05 ,  A61K41/00 ,  A61K8/21 ,  A61Q11/00 ,  A61L27/12 ,  A61K6/033 ,  A61K8/24 ,  A61K8/64 ,  A61K33/06 ,  A61K33/42 ,  A61L27/22 ,  A61K6/06

CPC分类号： A61N1/325 ,  A61C19/063 ,  A61C19/066 ,  A61K6/0017 ,  A61K6/033 ,  A61K6/0643 ,  A61K8/19 ,  A61K8/21 ,  A61K8/24 ,  A61K8/64 ,  A61K33/06 ,  A61K33/42 ,  A61K41/0047 ,  A61K2300/00 ,  A61K2800/83 ,  A61L27/12 ,  A61L27/22 ,  A61N1/0548 ,  A61Q11/00 ,  C08L1/284 ,  C08L29/04 ,  C08L29/14 ,  C08L31/04 ,  C08L33/14 ,  C08L71/02 ,  C08L89/005

摘要： A cosmetic and/or therapeutic treatment of tissue, such as tooth, is disclosed that effects, for instance, whitening and tissue re-building through mineralization. Further, a method of performing iontophoresis utilizing an aqueous composition of a remineralizing agent to achieve mineralization is disclosed, as well as a kit for performing the mineralization or remineralization.

公开(公告)号：US10034960B2

公开(公告)日：2018-07-31

申请号：US14895617

申请日：2014-06-06

申请人： University of Maryland, College Park ,  Children's National Medical Center

发明人： John Patrick Fisher ,  Anthony Melchiorri ,  Narutoshi Hibino ,  Axel Krieger ,  John P. Costello ,  Carolyn Cochenour

IPC分类号： A61L27/16 ,  C08G63/91 ,  A61L27/22 ,  A61L27/26 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  C08F267/06 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

CPC分类号： A61L27/16 ,  A61L27/22 ,  A61L27/26 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/252 ,  A61L2300/256 ,  A61L2300/414 ,  A61L2430/20 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C08F267/06 ,  C08G63/918 ,  C08K5/04 ,  C08L67/06 ,  C08K5/092 ,  C08K5/5397 ,  C08K5/132

摘要： A composition including PPF or a PPF copolymer that can be used to fabricate biodegradable structures. The composition can be used in 3-D patterning (e.g., 3-D printing and sterolighography) methods. For example, 3-D patternable compositions include PPF or a PPF copolymer, a photoinitiator or photoinitiators, and a resolution control inhibitor or inhibitors. The compositions can be used to make biodegradable structures (such as cardivascular scaffolds). The biodegradable structures can be surface functionalized. The biodegradable structures can be used in methods of blood delivery in an individual.

公开(公告)号：US20180111979A1

公开(公告)日：2018-04-26

申请号：US15566034

申请日：2015-10-06

申请人： UAB FERENTIS

发明人： Jaywant Babasaheb PHOPASE

IPC分类号： C07K14/78 ,  A61L27/24 ,  A61L27/52

CPC分类号： C07K14/78 ,  A61F2/142 ,  A61L27/22 ,  A61L27/24 ,  A61L27/3813 ,  A61L27/3834 ,  A61L27/50 ,  A61L27/52 ,  A61L27/54 ,  A61L2430/16

摘要： This disclosure relates to a novel Collagen Mimetic Peptide; a multi-arm conjugate comprising said peptide that mimics the higher order triple helical self-assembly of a collagen; a hydrogel comprising said Collagen Mimetic Peptide, optionally comprising collagen and optionally comprising a chemically modified surface; a corneal implant based on said hydrogel/modified hydrogel comprising a transparent central portion formed by an interpenetrating network comprising one or more additional biocompatible polymers wherein the central portion is adapted to remain cell free to ensure unhindered transmission of light.

公开(公告)号：US20180064782A1

公开(公告)日：2018-03-08

申请号：US15818602

申请日：2017-11-20

申请人： Arch Biosurgery, Inc.

发明人： Terrence Norchi ,  Steven Kates ,  Rutledge Ellis-Behnke

IPC分类号： A61K38/10 ,  A61L31/14 ,  A61L31/04 ,  A61K9/70 ,  A61K38/02 ,  A61L26/00 ,  A61L27/22 ,  A61L15/32 ,  A61L31/16

CPC分类号： A61K38/10 ,  A61K9/70 ,  A61K9/7007 ,  A61K38/02 ,  A61L15/32 ,  A61L26/0028 ,  A61L26/0047 ,  A61L27/22 ,  A61L27/227 ,  A61L31/043 ,  A61L31/047 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/418 ,  A61L2400/12

摘要： Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable. In one embodiment, the mesh is formed from one or more self-assembling peptides. The peptides can be in the form of fibers, such as nanofibers. The peptides can be assembled prior to formation of the mesh or after the mesh has been formed but before it is applied. Alternatively, the mesh can be prepared from unassembled peptides, which assemble at the time of application. The peptides can assemble upon contact with bodily fluids (e.g., blood) or can be contacted with an ionic solution to initiate assembly.

公开(公告)号：US09889236B2

公开(公告)日：2018-02-13

申请号：US15060485

申请日：2016-03-03

申请人： Micromedics Inc.

发明人： Saeid Mordechai Nosrati

IPC分类号： A61L27/60 ,  A61L27/54 ,  A61L27/18 ,  A61L27/56 ,  A61L27/26 ,  A61L27/22 ,  A61L27/34 ,  A61F13/02 ,  A61M35/00 ,  A61F13/00

CPC分类号： A61L27/60 ,  A61F13/0216 ,  A61F13/022 ,  A61F13/0226 ,  A61F2013/0017 ,  A61F2013/00285 ,  A61L27/18 ,  A61L27/22 ,  A61L27/26 ,  A61L27/34 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/412 ,  A61L2300/608 ,  A61L2420/08 ,  A61L2430/16 ,  A61L2430/34 ,  A61M35/00 ,  A61M2202/0208 ,  C08L83/04

摘要： A scalable microfluidic based artificial skin covers a variety of wounds while also providing efficient healing of the wounds. The artificial skin comprises a plurality of microfluidic panels separated by semi-permeable membranes, and also comprising a plurality of micro-pumps and micro-channels for carrying healing fluids in proximity to the wound on the natural skin. The panels form detachable patches that are inert and biocompatible. The panels are fabricated from polydimethylsiloxane materials and impregnated with silver nanocrystalline powder. A first panel partially engages the natural skin, partially supported by micro-pillars. Large micro-channels carry contaminants from the wound. A second panel and an optional third panel having micro-channels that carry healing fluids to the wound. A first and second semi-permeable membrane regulate passage of fluids, cellular components, and debris between the panels. An inlet port enables passage of healing fluids to the wound. An outlet port enables discharge of contaminants.

公开(公告)号：US09878067B2

公开(公告)日：2018-01-30

申请号：US14442209

申请日：2013-09-12

申请人： G-Group LLC

发明人： Olga Ivanovna Burlutskaya ,  Ramil Rafailevich Rakhmatullin ,  Tatyana Ivanovna Burtseva ,  Abay Izhbulatovich Adelshin

IPC分类号： A61L27/20 ,  A61L2/22 ,  A61F2/10 ,  A61L26/00 ,  A61L27/22

CPC分类号： A61L27/20 ,  A61L26/0023 ,  A61L26/008 ,  A61L27/22 ,  C08L5/08

摘要： The invention relates to medicine and specifically to combustiology, to surgery, and to cosmetology and can be used as a bioplastic material for replacing defects in epithelial tissues (protecting against evaporation and infection) and for stimulating regeneration. The technical result is increased efficacy in healing wounds. The goal is achieved in that a histo-equivalent bioplastic material is used which includes a substrate in the form of a matrix, the material for which is a native form of hyaluronic acid, distinguished in that the histo-equivalent bioplastic material contains a 1.5% solution of hyaluronic acid and a 5% solution of a peptide complex which are mixed until a viscous elastic gel is formed, situated in the foundation and subjected to ultraviolet photopolymerization in a biosafety cabinet over the course of 5-7 hours at the following quantitative ratio in ml: 1.5% solution of hyaluronic acid solution: 80-90%; 5% solution of peptide complex: 10-20%; the finished material has perforations and notches.

公开(公告)号：US20170304503A1

公开(公告)日：2017-10-26

申请号：US15499977

申请日：2017-04-28

申请人： FUJIFILM Corporation

发明人： Kentaro NAKAMURA

IPC分类号： A61L27/50 ,  A61L27/22 ,  A61F2/06 ,  A61L27/36 ,  C12N5/00 ,  A61L27/54

CPC分类号： A61L27/507 ,  A61F2/06 ,  A61L27/22 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/3604 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/80 ,  C12M3/00 ,  C12N5/0068

摘要： An object of the present invention is to provide a cell-containing bioabsorbable tubular structure having molecular permeability, a device for manufacturing the tubular structure, and a method for manufacturing the tubular structure. According to the present invention, there is provided a tubular structure constituted with a cell structure which contains biocompatible polymer blocks and cells, in which the plurality of polymer blocks is disposed in voids between the plurality of cells.

公开(公告)号：US20170182218A1

公开(公告)日：2017-06-29

申请号：US15398288

申请日：2017-01-04

申请人： Agency for Science, Technology and Research

发明人： Charlotte Hauser ,  Wei Yang Seow

IPC分类号： A61L27/38 ,  C12N5/00 ,  A61K47/42 ,  A61L26/00 ,  A61L27/52 ,  A61L27/22

CPC分类号： A61L27/3804 ,  A61K9/06 ,  A61K35/33 ,  A61K38/02 ,  A61K47/42 ,  A61L26/0028 ,  A61L26/0061 ,  A61L26/008 ,  A61L27/22 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  A61L2300/412 ,  A61L2300/426 ,  A61L2400/06 ,  A61L2430/00 ,  A61L2430/06 ,  A61L2430/38 ,  C12N5/0018 ,  C12N5/0062 ,  C12N5/0068 ,  C12N5/0671 ,  C12N5/0691 ,  C12N2513/00 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2537/10

摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.

公开(公告)号：US20170182215A1

公开(公告)日：2017-06-29

申请号：US15455192

申请日：2017-03-10

申请人： Pioneer Surgical Technology, Inc.

发明人： Francis Vincent Lamberti ,  Richard Chris Klann ,  Ronald Stewart Hill

IPC分类号： A61L27/34 ,  A61L27/44 ,  A61L27/36 ,  A61L27/52 ,  A61L27/46

CPC分类号： A61L27/222 ,  A61F2/0063 ,  A61K47/42 ,  A61L27/025 ,  A61L27/12 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/3608 ,  A61L27/446 ,  A61L27/46 ,  A61L27/52 ,  A61L27/54 ,  A61L31/10 ,  A61L2300/112 ,  A61L2300/412 ,  A61L2420/04 ,  A61L2420/06 ,  A61L2430/02 ,  B29C39/003 ,  B29L2031/7532 ,  Y10T428/29 ,  Y10T428/2947 ,  Y10T428/31551 ,  Y10T428/31786 ,  C08L5/02 ,  C08L89/00

摘要： The present invention is directed to a stabilized bioactive hydrogel matrix coating for substrates, such as medical devices. The invention provides a coated substrate comprising a substrate having a surface, and a bioactive hydrogel matrix layer overlying the surface of the medical device, the hydrogel matrix comprising a first high molecular weight component and a second high molecular weight component, the first and second high molecular weight components each being selected from the group consisting of polyglycans and polypeptides, wherein at least one of the first and second high molecular weight components is immobilized (e.g., by covalent cross-linking) to the surface of the substrate.

公开(公告)号：US09681940B2

公开(公告)日：2017-06-20

申请号：US14456286

申请日：2014-08-11

申请人： Biomet Sports Medicine, LLC

发明人： Kevin T. Stone ,  Robert Metzger

IPC分类号： A61F2/08 ,  A61B17/04 ,  A61L27/10 ,  A61L27/22 ,  A61L27/04 ,  A61B17/00 ,  A61B17/06

CPC分类号： A61F2/08 ,  A61B17/0401 ,  A61B2017/00336 ,  A61B2017/00858 ,  A61B2017/0404 ,  A61B2017/0409 ,  A61B2017/0417 ,  A61B2017/0435 ,  A61B2017/044 ,  A61B2017/0458 ,  A61B2017/0477 ,  A61B2017/06185 ,  A61F2/0811 ,  A61F2002/0823 ,  A61F2002/0829 ,  A61F2002/0835 ,  A61F2002/0852 ,  A61F2002/0864 ,  A61F2002/0882 ,  A61F2210/0004 ,  A61F2220/0033 ,  A61F2230/0069 ,  A61F2230/0095 ,  A61F2250/0007 ,  A61F2250/0012 ,  A61F2250/0018 ,  A61F2250/0029 ,  A61L27/04 ,  A61L27/10 ,  A61L27/22

摘要： A system for an anatomical joint includes a first fastener, a second fastener, a prosthetic ligament member, and a biasing member associated with at least one of the first and second fasteners. The first fastener is operable to be connected to a first bone portion. The second fastener is operable to be connected to a second bone portion. The prosthetic ligament member is flexible and is directly coupled to both the first and second fasteners to support the first bone portion and the second bone portion for relative movement. A portion of the prosthetic ligament member extends from the first fastener to the second fastener and has an adjustable length. The biasing member is operable to bias the prosthetic ligament member to thereby maintain tension in the prosthetic ligament member.