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公开(公告)号：US20110269747A1
公开(公告)日：2011-11-03
申请号：US13181624
申请日：2011-07-13
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/495 , C07D211/34 , C07D401/12 , C07D211/32 , C07D243/08 , C07D211/58 , C07D409/12 , C07D405/12 , A61K31/451 , A61K31/496 , A61K31/4545 , A61K31/5513 , A61P3/06 , A61P3/04 , A61P3/10 , A61P9/10 , A61P7/00 , A61P1/18 , A61P9/00 , C07D241/04
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译： 式（I）的聚芳基酰胺化合物可用作降脂剂。
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公开(公告)号：US08258304B2
公开(公告)日：2012-09-04
申请号：US12351385
申请日：2009-01-09
IPC分类号： A61K31/454 , A61K31/451 , C07D211/62 , C07D213/75
CPC分类号： C07D401/04 , C07D211/34 , C07D211/62
摘要： N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
摘要翻译： 式（I）的N-芳基哌啶取代的联苯甲酰胺化合物制备此类化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。
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公开(公告)号：US20090156623A1
公开(公告)日：2009-06-18
申请号：US12351385
申请日：2009-01-09
IPC分类号： A61K31/4545 , C07D211/32 , C07D401/04 , A61P3/10 , A61P9/10 , A61P3/04 , A61K31/506 , A61K31/451
CPC分类号： C07D401/04 , C07D211/34 , C07D211/62
摘要： N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes.
摘要翻译： 式（I）的N-芳基哌啶取代的联苯甲酰胺化合物制备此类化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。
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公开(公告)号：US20080125412A1
公开(公告)日：2008-05-29
申请号：US11928942
申请日：2007-10-30
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/55 , A61K31/495 , C07D243/08 , C07D211/10 , C07D241/04 , A61K31/451
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译： 式（I）的聚芳基酰胺化合物可用作降脂剂。
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公开(公告)号：US07253157B2
公开(公告)日：2007-08-07
申请号：US11474911
申请日：2006-06-26
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/5513 , C07D243/08
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
摘要翻译： 式（I）的聚芳基酰胺化合物可用作降脂剂。
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公开(公告)号：US07169796B2
公开(公告)日：2007-01-30
申请号：US11029956
申请日：2005-01-05
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A61K31/445 , C07D211/14 , C07D401/10
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula I) are useful as lipid lowering agents.
摘要翻译： 式I）的聚芳酰基甲酰胺化合物可用作降脂剂。
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公开(公告)号：US06878724B2
公开(公告)日：2005-04-12
申请号：US10363665
申请日：2001-08-27
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： C07D243/08 , A61K31/4409 , A61K31/445 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/551 , A61P1/18 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/10 , A61P9/14 , C07D211/26 , C07D211/34 , C07D211/70 , C07D211/82 , C07D213/40 , C07D213/55 , C07D213/56 , C07D295/14 , C07D295/15 , C07D307/54 , C07D333/24 , C07D401/12 , A61K31/451 , C07D211/28 , C07D211/32
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I): are useful as lipid lowering agents.
摘要翻译： 式（I）的聚芳酰基甲酰胺化合物：可用作降脂剂。
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8.发明授权MTP inhibiting aryl piperidines or piperazines substituted with 5-membered heterocycles 有权MTP抑制芳基哌啶或被5元杂环取代的哌嗪公开(公告)号：US07816360B2
公开(公告)日：2010-10-19
申请号：US12341567
申请日：2008-12-22
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
IPC分类号： A61K31/496 , A61K31/454 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D417/12 , C07D487/04 , C07D233/74 , C07D249/12
CPC分类号： C07D233/54 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
摘要翻译： 本发明涉及用具有apoB分泌/ MTP抑制活性和伴随的降脂活性的某些5-元杂环取代的新的芳基哌啶或哌嗪化合物。 本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。 本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗动脉粥样硬化，胰腺炎，肥胖症，高甘油三酯血症，高胆固醇血症，高脂血症，糖尿病和II型糖尿病的药物的用途。
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9.发明授权MTP inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles 有权用5元杂环取代的MTP抑制芳基哌啶或哌嗪公开(公告)号：US07504400B2
公开(公告)日：2009-03-17
申请号：US10589515
申请日：2005-03-07
申请人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
发明人： Lieven Meerpoel , Leo Jacobus Jozef Backx , Libuse Jaroskova , Peter Walter Maria Roevens , Louis Jozef Elisabeth Van Der Veken , Marcel Viellevoye , Joannes Theodorus Maria Linders
IPC分类号： A61K31/496 , A61K31/454 , C07D295/15 , C07D401/04 , C07D401/10 , C07D401/12 , C07D417/121
CPC分类号： C07D233/54 , C07D249/08 , C07D401/04 , C07D401/14 , C07D403/10 , C07D413/12 , C07D417/10 , C07D417/12
摘要： The present invention is concerned with novel aryl piperidine or piperazine compounds substituted with certain 5-membered heterocycles having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hyper-triglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
摘要翻译： 本发明涉及用具有apoB分泌/ MTP抑制活性和伴随的降脂活性的某些5-元杂环取代的新的芳基哌啶或哌嗪化合物。 本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗高脂血症，肥胖症和II型糖尿病的药物的用途。 本发明还涉及制备这些化合物的方法，包含所述化合物的药物组合物以及所述化合物作为治疗动脉粥样硬化，胰腺炎，肥胖症，高甘油三酯血症，高胆固醇血症，高脂血症，糖尿病和II型糖尿病的药物的用途 。
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公开(公告)号：US08354402B2
公开(公告)日：2013-01-15
申请号：US13181624
申请日：2011-07-13
申请人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
发明人： Lieven Meerpoel , Peter Walter Maria Roevens , Leo Jacobus Jozef Backx , Louis Jozef Elisabeth Van der Veken , Marcel Viellevoye
IPC分类号： A01N43/62 , C07D295/00
CPC分类号： C07D213/40 , C07D211/26 , C07D211/34 , C07D211/70 , C07D213/55 , C07D213/56 , C07D241/04 , C07D243/08 , C07D295/15 , C07D307/54 , C07D333/24
摘要： Polyarylcarboxamide compounds of formula (I) are useful as lipid lowering agents.
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