公开(公告)号：US07245973B2

公开(公告)日：2007-07-17

申请号：US10745302

申请日：2003-12-23

申请人： Lili Liu ,  Randy Westlund ,  Steven D. Girouard

发明人： Lili Liu ,  Randy Westlund ,  Steven D. Girouard

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

摘要翻译： 心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。 引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。 引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。 管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。 管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。 可导向的管心针允许心内区域的电生理作图。 中空针允许将化学，生物化学和/或生物物质递送至心内区域。

公开(公告)号：US08078287B2

公开(公告)日：2011-12-13

申请号：US11760294

申请日：2007-06-08

申请人： Lili Liu ,  Randy Westlund ,  Steven D. Girouard

发明人： Lili Liu ,  Randy Westlund ,  Steven D. Girouard

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

摘要翻译： 心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。 引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。 引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。 管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。 管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。 可导向的管心针允许心内区域的电生理作图。 中空针允许将化学，生物化学和/或生物物质递送至心内区域。

公开(公告)号：US20050090883A1

公开(公告)日：2005-04-28

申请号：US10617881

申请日：2003-07-14

申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher Zerby

发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher Zerby

IPC分类号： A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。

公开(公告)号：US06634364B2

公开(公告)日：2003-10-21

申请号：US09738590

申请日：2000-12-15

申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

IPC分类号： A61N105

CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。

公开(公告)号：US07657324B2

公开(公告)日：2010-02-02

申请号：US10617881

申请日：2003-07-14

申请人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

发明人： Randy Westlund ,  Bruce Tockman ,  Gwen Crevensten ,  Lili Liu ,  Christopher M. Zerby

IPC分类号： A61N1/05

CPC分类号： A61N1/0565 ,  A61N1/056 ,  A61N1/0573

摘要： A seal adapted for use with medical devices is provided. The medical device may be a lead having a distal tip adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity. The lead assembly in one embodiment includes an atraumatic tip. A seal is provided within the lead tip assembly, which prevents or limits further entry of fluids through the lead tip. The lead may be a left ventricular lead with a hemostasis mechanism provided therewithin.

摘要翻译： 提供适于与医疗装置一起使用的密封件。 医疗装置可以是具有适于植入在心脏上或周围的远端的引线，并且用于连接到用于监测或刺激心脏活动的系统。 在一个实施例中的引线组件包括无创伤的尖端。 在引线端头组件内提供密封件，其防止或限制流体进一步进入引线尖端。 铅可以是在其中设置有止血机构的左心室导联。

公开(公告)号：US20070233216A1

公开(公告)日：2007-10-04

申请号：US11760294

申请日：2007-06-08

申请人： Lili Liu ,  Randy Westlund ,  Steven Girouard

发明人： Lili Liu ,  Randy Westlund ,  Steven Girouard

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

摘要翻译： 心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。 引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。 引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。 管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。 管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。 可导向的管心针允许心内区域的电生理作图。 中空针允许将化学，生物化学和/或生物物质递送至心内区域。

公开(公告)号：US07239923B1

公开(公告)日：2007-07-03

申请号：US09630000

申请日：2000-08-01

申请人： Bruce Tockman ,  Randy Westlund ,  Gwen Crevensten ,  Lili Liu ,  Chris Zerby ,  Jay A. Warren

发明人： Bruce Tockman ,  Randy Westlund ,  Gwen Crevensten ,  Lili Liu ,  Chris Zerby ,  Jay A. Warren

IPC分类号： A61N1/05

CPC分类号： A61N1/057 ,  A61N2001/0585

摘要： An apparatus includes a lead body extending from a proximal end to a distal end and having an intermediate portion therebetween. The lead body includes two or more individually insulated conductors, where a first conductor traverses along less than an entire length of the lead body and a second conductor traverses from the proximal end to the distal end of the lead body. Optionally, the first conductor has a different material than the second conductor, for instance having differing electrical properties and/or differing stiffnesses. A method includes varying the stiffness of a coiled conductor assembly including winding a plurality of conductors to form the coiled conductor assembly, and pulling at least one loop of a first conductor away from the coiled conductor assembly.

摘要翻译： 一种装置包括从近端延伸到远端并且在其间具有中间部分的引线体。 引线体包括两个或更多个单独绝缘的导体，其中第一导体沿着引线主体的小于整个长度横穿，并且第二导体从引线主体的近端穿过远端。 可选地，第一导体具有与第二导体不同的材料，例如具有不同的电特性和/或不同的刚度。 一种方法包括改变线圈导体组件的刚度，包括缠绕多个导体以形成线圈导体组件，以及将第一导体的至少一个环拉离线圈导体组件。

公开(公告)号：US20070239249A1

公开(公告)日：2007-10-11

申请号：US11762887

申请日：2007-06-14

申请人： Bruce Tockman ,  Randy Westlund ,  Gwen Crevensten ,  Lili Liu ,  Chris Zerby ,  Jay Warren

发明人： Bruce Tockman ,  Randy Westlund ,  Gwen Crevensten ,  Lili Liu ,  Chris Zerby ,  Jay Warren

IPC分类号： A61N1/05

CPC分类号： A61N1/056

摘要： An apparatus includes a lead body extending from a proximal end to a distal end and having an intermediate portion therebetween. The lead body includes two or more individually insulated conductors, where a first conductor traverses along less than an entire length of the lead body and a second conductor traverses from the proximal end to the distal end of the lead body. Optionally, the first conductor has a different material than the second conductor, for instance having differing electrical properties and/or differing stiffnesses. A method includes varying the stiffness of a coiled conductor assembly including winding a plurality of conductors to form the coiled conductor assembly, and pulling at least one loop of a first conductor away from the coiled conductor assembly.

摘要翻译： 一种装置包括从近端延伸到远端并且在其间具有中间部分的引线体。 引线体包括两个或更多个单独绝缘的导体，其中第一导体沿着引线主体的小于整个长度横穿，并且第二导体从引线主体的近端穿过远端。 可选地，第一导体具有与第二导体不同的材料，例如具有不同的电特性和/或不同的刚度。 一种方法包括改变线圈导体组件的刚度，包括缠绕多个导体以形成线圈导体组件，以及将第一导体的至少一个环拉离线圈导体组件。

公开(公告)号：US20050137671A1

公开(公告)日：2005-06-23

申请号：US10745302

申请日：2003-12-23

申请人： Lili Liu ,  Randy Westlund ,  Steven Girouard

发明人： Lili Liu ,  Randy Westlund ,  Steven Girouard

IPC分类号： A61N1/05

CPC分类号： A61N1/0568

摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.

摘要翻译： 心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。 引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。 引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。 管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。 管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。 可导向的管心针允许心内区域的电生理作图。 中空针允许将化学，生物化学和/或生物物质递送至心内区域。

公开(公告)号：US09031861B1

公开(公告)日：2015-05-12

申请号：US13242772

申请日：2011-09-23

申请人： Lili Liu ,  Chao Cai ,  Paul Liu ,  Sissie Ling-le Hsiao ,  Karl Pfleger

发明人： Lili Liu ,  Chao Cai ,  Paul Liu ,  Sissie Ling-le Hsiao ,  Karl Pfleger

IPC分类号： G06Q30/00 ,  G06Q30/02

CPC分类号： G06Q30/0205

摘要： Methods, systems, and computer program products are provided for measuring effectiveness of content items included in a campaign. One example method includes providing a corpus of campaigns, where a campaign defines parameters for presentation that specify circumstances under which content items are presented to users in response to requests. The corpus is filtered by identifying one or more candidate campaigns, where each of the identified candidate campaigns is associated with a geographic region and includes one or more constraints that permit pausing distribution of content items without compromising campaign goals. For each candidate campaign, one or more experimental geographic locations included in the geographic region are determined that are substantially representative of the region. Presentation of at least one of the content items is paused for a time period, and content item effectiveness is measured by comparing resource conversions for experimental and control geographic locations.

摘要翻译： 提供了方法，系统和计算机程序产品，用于衡量活动中包含的内容项目的有效性。 一种示例性方法包括提供广告系列语料库，其中活动定义用于呈现的参数，其指定响应于请求将内容项呈现给用户的情况。 通过识别一个或多个候选活动来筛选语料库，其中每个所识别的候选活动与地理区域相关联，并且包括允许在不影响活动目标的情况下暂停分配内容项目的一个或多个约束。 对于每个候选活动，确定包括在地理区域中的一个或多个实验地理位置，其基本上代表该区域。 至少一个内容项的呈现暂停一段时间，通过比较实验和控制地理位置的资源转换来测量内容项有效性。