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公开(公告)号:US06790834B1
公开(公告)日:2004-09-14
申请号:US09514083
申请日:2000-02-28
IPC分类号: C07K506
CPC分类号: C07D333/34 , A61K31/216 , A61K31/223 , A61K31/341 , A61K31/381 , A61K31/4406 , A61K31/445 , C07C259/06 , C07C2601/08 , C07D211/46 , C07D213/55 , C07D307/20
摘要: Compounds of formula I are disclosed wherein R4 is an ester or thioester group, and R, R1, R2, and R3 are as defined in the specification are inhibitors of rapidly dividing tumor cells.
摘要翻译: 公开了式I化合物,其中R 4是酯或硫酯基,R 1,R 2,R 2和R 3如本说明书中所定义,是快速分裂肿瘤细胞的抑制剂。
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公开(公告)号:US06462023B1
公开(公告)日:2002-10-08
申请号:US09100539
申请日:1998-06-19
IPC分类号: C07K506
CPC分类号: A61K31/216 , A61K31/223 , A61K31/341 , A61K31/381 , A61K31/4406 , A61K31/445 , C07C259/06 , C07C2601/08 , C07D211/46 , C07D213/55 , C07D307/20 , C07D333/34
摘要: The present invention provide compounds exemplified by 2(R or S)-[2R-(S-Hydroxy-hydroxycarbamoyl-methyl)-4-methyl-pentanoylamine]-2-phenyl-ethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-phenylethanoic acid isopropyl ester; 2(R or S)-[2R-(S-Hydroxycarbamoyi-methoxy-methyl)-4-methyl-pentanoylamino]-3-phenylethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(4-methoxyphenyl)ethanoic acid cyclopentyl ester; 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(thien-2-yl)ethanoic acid cyclopentyl ester; and 2(R or S)-(3S-Hydroxycarbamoyl-2R-isobutyl-hex-5-enoylamino)-2-(thien-3-yl)ethanoic acid cyclopentyl ester are cytostatic agents. Methods of treating proliferative cell growth disorders as well a methods of inhibiting hyper-proliferative cells are also disclosed.
摘要翻译: 本发明提供了2(R或S) - [2R-(S-羟基 - 羟基氨基甲酰基 - 甲基)-4-甲基 - 戊酰胺] -2-苯基 - 乙酸环戊酯的实例化合物; 2(R或S) - (3S-羟基氨基甲酰基 - 2R-异丁基 - 己-5-烯酰基氨基)-2-苯基乙酸异丙酯; 2(R或S) - [2R-(S-羟基氨基甲酰基 - 甲氧基 - 甲基)-4-甲基 - 戊酰基氨基] -3-苯基乙酸环戊酯; 2(R或S) - (3S-羟基氨基甲酰基-2R-异丁基 - 己-5-烯酰基氨基)-2-(4-甲氧基苯基)乙酸环戊酯; 2(R或S) - (3S-羟基氨基甲酰基-R 2R-异丁基 - 己-5-烯酰基氨基)-2-(噻吩-2-基)乙酸环戊酯; 和2(R或S) - (3S-羟基氨基甲酰基-R 2R-异丁基 - 己-5-烯酰基氨基)-2-(噻吩-3-基)乙酸环戊酯是细胞抑制剂。 还公开了治疗增殖性细胞生长障碍的方法以及抑制高增殖细胞的方法。
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公开(公告)号:US20070160989A1
公开(公告)日:2007-07-12
申请号:US10568691
申请日:2004-08-18
申请人: Lindsay Bawden , Elizabeth Bone , Alan Drummond , Lindsey Needham
发明人: Lindsay Bawden , Elizabeth Bone , Alan Drummond , Lindsey Needham
IPC分类号: C12Q1/68 , G01N33/574
CPC分类号: G01N33/564 , G01N33/57488 , G01N33/6875 , G01N2800/24 , G01N2800/7028
摘要: This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein. Binding of the antibody to the nucleosomes is indicative that the individual has the disease condition.
摘要翻译: 本发明涉及通过对来自个体的样品中的无细胞核小体的分析来诊断疾病状况,如癌症和自身免疫性疾病。 本发明的方法可以包括使从细胞获得的生物流体样品中的无细胞核小体与经修饰的组蛋白特异性结合的抗体接触。 抗体与核小体的结合表明个体具有疾病状况。
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4.
公开(公告)号:US20050069931A1
公开(公告)日:2005-03-31
申请号:US10922806
申请日:2004-08-19
申请人: C. Allis , David Bruns , Alan Drummond
发明人: C. Allis , David Bruns , Alan Drummond
IPC分类号: C07K1/22 , C07K16/18 , C12M1/00 , C12N15/09 , C12P19/34 , C12Q1/68 , G01N33/53 , G01N33/68 , G01N37/00
CPC分类号: G01N33/6842 , C12Q1/6809 , G01N33/5308 , G01N33/68 , G01N33/6875 , C12Q2565/113 , C12Q2563/119
摘要: The present invention relates to the use of antibodies directed against specific histone amino terminus modifications as diagnostic indicators of disease or congenital defects. In one embodiment, nucleosomes are isolated from a blood or serum sample of a patient using histone specific antibodies and the accompanying DNA is purified and analyzed for diagnostic and screening purposes.
摘要翻译: 本发明涉及针对特定组蛋白氨基末端修饰的抗体作为疾病或先天缺陷诊断指标的用途。 在一个实施方案中,使用组蛋白特异性抗体从患者的血液或血清样品中分离核小体,并纯化并伴随DNA进行诊断和筛选。
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