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公开(公告)号：US20070232600A1
公开(公告)日：2007-10-04
申请号：US11620291
申请日：2007-01-05
申请人： Ling Chen , Prasad Chaturvedula , Rita Civiello , Andrew Degnan , Gene Dubowchik , Xiaojun Han , Xiang Jun Jiang , George Karageorge , Guanglin Luo , John Macor , Graham Poindexter , George Tora
发明人： Ling Chen , Prasad Chaturvedula , Rita Civiello , Andrew Degnan , Gene Dubowchik , Xiaojun Han , Xiang Jun Jiang , George Karageorge , Guanglin Luo , John Macor , Graham Poindexter , George Tora
IPC分类号： A61K31/517 , A61K31/536
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/106 , A01K2267/0306 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/10 , C12N15/8509 , G01N33/566 , G01N2500/10 , G01N2800/2807
摘要： The present invention relates to methods of treating neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors using pharmaceutical compositions comprising compounds of Formula (I)
摘要翻译： 本发明涉及治疗神经源性血管舒张，神经源性炎症，偏头痛等头痛，热损伤，循环休克，与绝经相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺病（COPD）等方法。 使用包含式（I）化合物的药物组合物可以通过CGRP受体的拮抗作用来治疗其，
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公开(公告)号：US20050153959A1
公开(公告)日：2005-07-14
申请号：US11004706
申请日：2004-12-03
申请人： Guanglin Luo , Ling Chen , Andrew Degnan , Gene Dubowchik , John Macor , George Tora , Prasad Chaturvedula
发明人： Guanglin Luo , Ling Chen , Andrew Degnan , Gene Dubowchik , John Macor , George Tora , Prasad Chaturvedula
IPC分类号： C07D401/14 , C07D413/14 , C07D471/10 , C07D417/02 , A61K31/541 , C07D413/02 , C07D43/02 , C07D49/02
CPC分类号： C07D471/10 , C07D401/14 , C07D413/14
摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明涉及作为降钙素基因相关肽受体（“CGRP受体”）拮抗剂的式（I）化合物，包含它们的药物组合物，鉴定它们的方法，使用它们的治疗方法及其在治疗治疗中的用途 神经源性血管舒张，神经源性炎症，偏头痛和其他头痛，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）以及其他治疗可以通过 CGRP受体的拮抗作用。
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公开(公告)号：US20070149502A1
公开(公告)日：2007-06-28
申请号：US11620253
申请日：2007-01-05
申请人： Prasad Chaturvedula , Gene Dubowchik , Xiang Jun Jiang , John Macor , Graham Poindexter , Shikha Vig
发明人： Prasad Chaturvedula , Gene Dubowchik , Xiang Jun Jiang , John Macor , Graham Poindexter , Shikha Vig
IPC分类号： A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/454 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： A61K49/0008 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/106 , A01K2267/0306 , A61K45/06 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/10 , C12N15/8509 , G01N33/566 , G01N2500/10 , G01N2800/2807
摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明涉及作为降钙素基因相关肽受体（“CGRP受体”）拮抗剂的式（I）化合物，包含它们的药物组合物，鉴定它们的方法，使用它们的治疗方法及其在治疗治疗中的用途 神经源性血管舒张，神经源性炎症，偏头痛和其他头痛，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺疾病（COPD）以及其他治疗可以通过 CGRP受体的拮抗作用。
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4.发明申请Novel processes for the preparation of CGRP-receptor antagonists and intermediates thereof 有权用于制备CGRP受体拮抗剂及其中间体的新方法公开(公告)号：US20060122250A1
公开(公告)日：2006-06-08
申请号：US11291670
申请日：2005-12-01
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D471/04 , C07D231/56 , C07D401/12 , C07D401/14
摘要： The invention relates to novel processes for the preparation of small molecule antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”) and intermediates thereof.
摘要翻译： 本发明涉及制备降钙素基因相关肽受体（“CGRP受体”）及其中间体的小分子拮抗剂的新方法。
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公开(公告)号：US20070049577A1
公开(公告)日：2007-03-01
申请号：US11508568
申请日：2006-08-23
申请人： Xiaojun Han , Prasad Chaturvedula
发明人： Xiaojun Han , Prasad Chaturvedula
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/506 , A61K31/496 , C07D417/02 , C07D413/02 , C07D403/02 , A61K31/497
CPC分类号： C07D401/14 , C07D413/14 , C07D471/04
摘要： The present invention encompasses compounds of Formula I which are antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
摘要翻译： 本发明包括作为降钙素基因相关肽受体（“CGRP受体”）的拮抗剂的式I化合物，包含它们的药物组合物，鉴定它们的方法，使用它们的治疗方法及其在治疗神经源性治疗中的用途 血管舒张，神经源性炎症，偏头痛和其他头痛，热损伤，循环休克，与更年期相关的潮红，气道炎症性疾病如哮喘和慢性阻塞性肺病（COPD）以及治疗可通过拮抗作用的其他病症 的CGRP受体。
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公开(公告)号：US20060229447A1
公开(公告)日：2006-10-12
申请号：US11417326
申请日：2006-05-03
IPC分类号： A61K31/55 , C07D403/14 , C07D487/10
CPC分类号： C07D471/04 , C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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公开(公告)号：US20060094707A1
公开(公告)日：2006-05-04
申请号：US11247697
申请日：2005-10-11
IPC分类号： A61K31/55 , C07D487/02
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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8.发明授权5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production 失效5-氨基-6-环己基-4-羟基 - 己酰胺衍生物作为β-淀粉样蛋白生产的抑制剂
公开(公告)号：US5703129A
公开(公告)日：1997-12-30
申请号：US723488
申请日：1996-09-30
IPC分类号： C07C237/14 , C07C323/41 , C07D307/33 , A61K31/17
CPC分类号： C07D307/33 , C07C237/14 , C07C323/41 , C07C2101/02 , C07C2101/08 , C07C2101/14
摘要： A series of 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives of Formula I have been synthesized. ##STR1## As inhibitors of the production of .beta.-amyloid protein from .beta.-amyloid precursor protein, these compounds are expected to be effective in treating patients suffering from or susceptible to conditions or disorders linked to brain accumulation of .beta.-amyloid protein; e.g., Alzheimer's Disease and Down's Syndrome.
摘要翻译： 已经合成了一系列式I的5-氨基-6-环己基-4-羟基 - 己酰胺衍生物。 （I）作为从β-淀粉样蛋白前体蛋白生产β-淀粉样蛋白的抑制剂，预期这些化合物可有效治疗患有或易于与β-淀粉样蛋白的脑积聚相关的病症或障碍的患者 ; 例如阿尔茨海默病和唐氏综合症。
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