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1.发明申请Medical Device Balloons with Improved Strength Properties and Processes for Producing the Same 审中-公开具有改进的强度属性的医疗装置气球及其制造方法公开(公告)号：US20120323301A1
公开(公告)日：2012-12-20
申请号：US13593756
申请日：2012-08-24
CPC分类号： A61L31/06 , A61L31/125 , A61M25/1029 , B29C47/0004 , B29C47/0023 , B29C47/822 , B29C47/86 , B29C47/862 , B29C47/8895 , B29L2031/7542 , Y10T428/1086
摘要： A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.
摘要翻译： 一种用于形成医疗装置气囊的管形型坯。 型坯由聚合物材料形成，例如热塑性弹性体。 型坯的断裂伸长率不大于本体聚合材料的伸长率的80％。 通过改变挤出条件来控制型坯的伸长率。 从型坯制备的气球比从相同材料的常规型坯制备的气球提供更高的壁强度和/或更高的充气耐久性。
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2.发明授权公开(公告)号：US07029732B2
公开(公告)日：2006-04-18
申请号：US10087653
申请日：2002-02-28
IPC分类号： C09K19/00
CPC分类号： A61L31/06 , A61L31/125 , A61M25/1029 , B29C47/0004 , B29C47/0023 , B29C47/822 , B29C47/86 , B29C47/862 , B29C47/8895 , B29L2031/7542 , Y10T428/1086
摘要： A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.
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3.发明授权公开(公告)号：US09801981B2
公开(公告)日：2017-10-31
申请号：US13593756
申请日：2012-08-24
IPC分类号： A61M29/00 , A61L31/06 , A61M25/10 , B29C47/00 , B29C47/86 , A61L31/12 , B29C47/82 , B29C47/88 , B29L31/00
CPC分类号： A61L31/06 , A61L31/125 , A61M25/1029 , B29C47/0004 , B29C47/0023 , B29C47/822 , B29C47/86 , B29C47/862 , B29C47/8895 , B29L2031/7542 , Y10T428/1086
摘要： A tubular parison for forming a medical device balloon. The parison is formed of a polymeric material, for instance a thermoplastic elastomer. The parison has an elongation at break which is not more than 80% of the elongation of the bulk polymeric material. The elongation of the parison is controlled by altering extrusion conditions. Balloons prepared from the parisons provide higher wall strength and/or higher inflation durability than balloons prepared from conventional parisons of the same material.
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4.发明授权公开(公告)号：US06280845B1
公开(公告)日：2001-08-28
申请号：US09381844
申请日：1999-09-23
IPC分类号： B32B904
CPC分类号： B32B7/12 , B32B7/02 , Y10S428/91 , Y10S428/921 , Y10T428/14 , Y10T428/2495 , Y10T428/24959 , Y10T428/24967 , Y10T428/24975 , Y10T428/28 , Y10T428/2848 , Y10T428/31504 , Y10T428/31551 , Y10T428/31786 , Y10T428/31855 , Y10T428/31931 , Y10T428/31938
摘要： The present invention provides unified multilayer films having at least one layer that includes a flame retardant film layer. In preferred embodiments the flame retardant film layer is an internal layer. In particularly preferred embodiments of the present invention, multilayer films include flame retardant layers alternating with non flame retardant layers. In other preferred embodiments, multilayer films include alternating layer of different flame retardant materials.
摘要翻译： 本发明提供具有至少一层包含阻燃膜层的统一多层膜。 在优选实施方案中，阻燃膜层是内层。 在本发明的特别优选的实施方案中，多层膜包括与非阻燃层交替的阻燃层。 在其它优选实施例中，多层膜包括不同阻燃材料的交替层。
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5.发明申请Methods and Apparatus for Forming and Connecting Cryoprobes for use with Cryosurgical Treatment Systems 审中-公开用于冷冻保存治疗系统使用的冷冻保存方法和装置公开(公告)号：US20080115509A1
公开(公告)日：2008-05-22
申请号：US11942029
申请日：2007-11-19
申请人： Adam L. Gullickson , Douglas A. Devens , David W. Vancelette , Michael W.V. Perkins , Randall C. Lieser
发明人： Adam L. Gullickson , Douglas A. Devens , David W. Vancelette , Michael W.V. Perkins , Randall C. Lieser
CPC分类号： A61B18/02 , A61B2018/0231
摘要： Methods and apparatus for connecting disposable and non-disposable portions of a cryoprobe for use with a cryosurgical treatment system. Representative cryoprobes can include a disposable and non-disposable portion joined with a connector such as a coupler for connecting a single disposable portion to a single non-disposable portion. A representative coupler can include coupler ports into which connecting ends of fluid delivery tubes within the disposable and non-disposable portions can fluidly connect. A manifold mounting plate can include a plurality of slots into which disposable portions can be fluidly interconnected to non-disposable portions.
摘要翻译： 用于连接用于冷冻手术治疗系统的冷冻探针的一次性和非一次性部分的方法和装置。 代表性的冷冻探针可以包括与诸如耦合器的连接器连接的一次性和非一次性部分，用于将单个一次性部分连接到单个非一次性部分。 代表性的联接器可以包括耦合器端口，一次性和非一次性部分内的流体输送管的连接端可以流体地连接到该联接器端口中。 歧管安装板可以包括多个狭槽，一次性部分可以流体地互连到非一次性部分。
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公开(公告)号：US20080114348A1
公开(公告)日：2008-05-15
申请号：US11939180
申请日：2007-11-13
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0262
摘要： The present disclosure is directed to the use of a cryoprotective agent to protect healthy tissue while damaged tissue is cryosurgically treated. A cryoprotective agent can be delivered utilizing a delivery probe that is inserted into healthy tissue either prior to or during a freeze portion of a first freeze/thaw cycle. The cryoprotective agent diffuses through the healthy tissue, but diffusion is controlled at the freeze edge by the diffusion limiting characteristics of the tissue that is frozen. When the frozen tissue is thawed, the disrupted tissue will continue to restrict the diffusion of the cryoprotective agent. Additional freeze/thaw cycles can then be conducted and the cryoprotective agent will continue to protect the healthy tissue. The delivery probes can also function as thermal sensor probes that can also be used to monitor the temperature at selected tissue locations.
摘要翻译： 本公开涉及使用冷冻保护剂来保护健康组织，同时受损组织被冷冻治疗。 冷冻保护剂可以在第一次冷冻/解冻循环的冷冻部分之前或期间使用插入健康组织的递送探针进行递送。 冷冻保护剂通过健康组织扩散，但是通过冷冻组织的扩散限制特性在冷冻边缘控制扩散。 当冷冻组织解冻时，破坏的组织将继续限制冷冻保护剂的扩散。 然后可以进行额外的冷冻/融化循环，并且冷冻保护剂将继续保护健康组织。 输送探针也可以用作热传感器探头，也可用于监测所选组织位置处的温度。
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公开(公告)号：US20080119838A1
公开(公告)日：2008-05-22
申请号：US11942219
申请日：2007-11-19
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2018/0212 , A61B2018/0231
摘要： A sheath for use with a cryoprobe in a cryosurgical procedure can have an opening at its proximal end configured to be inserted over a tip portion of a cryoprobe. The sheath can be connected to the cryoprobe with an end connector. Sheath can have a tip located at its distal that can have a trocar configuration for tissue penetration. A cylindrical section located inwardly from the tip can have a spiral groove defined on an exterior surface. At least one wire can be disposed within the groove so as to fit within the outer perimeter of the sheath. Wires disposed in grooves can include heating elements and temperature sensing elements. Sheath can further include a graduated catheter located inwardly from the cylindrical section and a handle located inwardly from the graduated catheter.
摘要翻译： 在冷冻手术过程中与冷冻探针一起使用的护套可以在其近端处具有开口，其构造成插入冷冻探针的尖端部分上。 护套可以用端接头连接到冷冻探针。 护套可以具有位于其远端的尖端，其可以具有用于组织穿透的套管针配置。 从尖端向内定位的圆柱形部分可以具有限定在外表面上的螺旋槽。 至少一根线可以设置在槽内，以便装配在护套的外周边内。 设置在凹槽中的电线可以包括加热元件和温度感测元件。 护套还可以包括从圆柱形部分向内定位的刻度导管和位于刻度导管内侧的手柄。
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公开(公告)号：US20080027420A1
公开(公告)日：2008-01-31
申请号：US11828095
申请日：2007-07-25
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B34/10 , A61B90/37 , A61B2017/00101
摘要： Improved imaging and monitoring systems for use with a closed loop cryosurgical system. As described herein, various systems can be used alone or in conjunction with one another to plan and/or monitor cryosurgical procedures in order to improve cryosurgical outcomes. These systems can include computer assisted planning systems, non-ultrasound based imaging systems and temperature monitoring systems utilized individually or in combination. Through the use of these systems, the precision by which cryosurgical procedures are performed are enhanced.
摘要翻译： 改进的成像和监测系统用于闭环冷冻手术系统。 如本文所述，各种系统可以单独使用或者彼此结合使用来规划和/或监测冷冻手术程序，以便改善冷冻手术的结果。 这些系统可以包括计算机辅助计划系统，基于非超声的成像系统和单独或组合使用的温度监测系统。 通过使用这些系统，提高了执行冷冻手术的精度。
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公开(公告)号：US20080119837A1
公开(公告)日：2008-05-22
申请号：US11940665
申请日：2007-11-15
IPC分类号： A61B18/02
CPC分类号： A61B18/02
摘要： The present disclosure is directed to a cryoprobe capable of improving the cooling power of a cryosurgical system. A representative cryoprobe can comprise an inner cooling chamber and a radial chamber, positioned between the inner cooling chamber and an exterior wall of the cryoprobe. Preferably, the radial chamber is formed to have a low thermal conductivity so as to significantly reduce the transfer of heat between the body and the refrigerant in the inner chamber during a cryosurgical procedure. The radial chamber can be fabricated such that a vacuum can be applied to the radial chamber to further reduce heat transfer between the body and the inner cooling chamber. The radial chamber extends partially along the length of the cryoprobe such that inner cooling chamber is in direct thermal contact with the exterior wall at a cryoprobe tip.
摘要翻译： 本公开涉及能够改善冷冻手术系统的冷却功率的冷冻探针。 代表性的冷冻探针可以包括位于内部冷却室和冷冻探针的外壁之间的内部冷却室和径向室。 优选地，径向室形成为具有低导热性，以便在冷冻手术过程期间显着地减少体内和内腔中的制冷剂之间的热传递。 可以制造径向室，使得可以向径向室施加真空以进一步减少主体和内部冷却室之间的热传递。 径向室沿着冷冻探针的长度部分延伸，使得内部冷却室在冷冻探针尖处与外壁直接热接触。
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公开(公告)号：US20080114347A1
公开(公告)日：2008-05-15
申请号：US11939078
申请日：2007-11-13
申请人： Douglas A. Devens , Steven B. Fine
发明人： Douglas A. Devens , Steven B. Fine
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/082 , A61B2018/00041 , A61B2018/0262
摘要： An improved closed loop cryosurgical system and related methods of use. The closed loop cryosurgical system can utilize a reduced size cryoprobe by moving a pre-cool heat exchanger into a control console for the system. The cyroprobe can further include a sheath having at least one thermal wire spaced around the sheath that can be heated using the control console so as to thaw frozen tissue. By incorporating thermal wiring into the sheath, the time necessary for a cryosurgical procedure can be significantly reduced, especially where multiple freeze-thaw cycles are conducted. In another aspect, an improved, environmentally friendly mixed gas refrigerant can be provided for use in cooling the cyroprobes. The mixed gas refrigerant avoids the use of the refrigerant R22 while also providing faster and more efficient ice ball formation at the cryoprobe tip, therefore allowing the cryosurgical treatment to be accomplished in less time.
摘要翻译： 一种改进的闭环冷冻手术系统及相关使用方法。 闭环冷冻手术系统可以通过将预冷热交换器移动到系统的控制台中来利用减小尺寸的冷冻探针。 该探针还可以包括护套，该护套具有围绕护套隔开的至少一个热丝，其可以使用控制台加热，以解冻冷冻的组织。 通过将热布线并入鞘中，可以显着降低冷冻手术所需的时间，特别是在进行多次冻融循环时。 另一方面，可以提供一种改进的，环境友好的混合气体制冷剂，用于冷却该探针。 混合气体制冷剂避免使用制冷剂R22，同时还在冷冻探针尖端提供更快更有效的冰球形成，从而允许在更短的时间内完成冷冻手术治疗。
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