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    PEPTIDES COMPRISING NON-NATURAL AMINO ACIDS AND METHODS OF MAKING AND USING THE SAME
    2.
    发明申请
    PEPTIDES COMPRISING NON-NATURAL AMINO ACIDS AND METHODS OF MAKING AND USING THE SAME 有权
    包含非天然氨基酸的肽及其制备和使用方法

    公开(公告)号：US20160045572A1

    公开(公告)日：2016-02-18

    申请号：US14776566

    申请日：2014-03-17

    Applicant: Scott SHANDLER ,  Samuel H. GELLMAN ,  John M. GLEDHILL ,  LONGEVITY BIOTECH, INC.

    Inventor： Scott Shandler ,  Samuel H. Gellman ,  John M. Gledhill

    IPC: A61K38/22 ,  G01N33/74 ,  A61J1/00 ,  C07K14/575

    CPC classification number: A61K38/2278 ,  A61J1/00 ,  C07K14/57563 ,  G01N33/74 ,  G01N2500/04 ,  G01N2500/10

    Abstract: This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.

    Abstract translation: 本发明涉及包含天然存在的多肽的类似物的新型组合物，其中该类似物包含α-氨基酸和至少一种β-氨基酸。 组合物的施用可以用于治疗或预防由功能失调的生物化学或生物学途径引起的多种疾病状态。 与衍生类似物的天然翻译的多肽相比，本发明的组合物和方法特别可用于鉴定具有延长半衰期和相关生物活性的体内受体活性的新型治疗调节剂。

    HIGHLY ACTIVE POLYPEPTIDES AND METHODS OF MAKING AND USING THE SAME
    4.
    发明申请
    HIGHLY ACTIVE POLYPEPTIDES AND METHODS OF MAKING AND USING THE SAME 有权

    公开(公告)号：US20210205415A1

    公开(公告)日：2021-07-08

    申请号：US16940610

    申请日：2020-07-28

    Applicant: Longevity Biotech, Inc.

    Inventor： Scott J. Shandler ,  Samuel H. Gellman

    IPC: A61K38/22 ,  C07K14/575

    Abstract: This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.

    HIGHLY ACTIVE POLYPEPTIDES AND METHODS OF MAKING AND USING THE SAME
    7.
    发明申请
    HIGHLY ACTIVE POLYPEPTIDES AND METHODS OF MAKING AND USING THE SAME 审中-公开

    公开(公告)号：US20180193422A1

    公开(公告)日：2018-07-12

    申请号：US15691811

    申请日：2017-08-31

    Applicant: Longevity Biotech, Inc.

    Inventor： Scott J. Shandler ,  Samuel H. Gellman

    IPC: A61K38/22 ,  C07K14/575

    CPC classification number: A61K38/2278 ,  C07K14/57563

    Abstract: This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.

    Highly active polypeptides and methods of making and using the same
    8.
    发明授权
    Highly active polypeptides and methods of making and using the same 有权

    公开(公告)号：US10772934B2

    公开(公告)日：2020-09-15

    申请号：US15691811

    申请日：2017-08-31

    Applicant: Longevity Biotech, Inc.

    Inventor： Scott J. Shandler ,  Samuel H. Gellman

    IPC: A61K38/22 ,  C07K14/575

    Abstract: This invention relates to novel compositions comprising analogs of naturally occurring polypeptides, wherein the analog comprises an α-amino acid and at least one β-amino acid. Administration of the compositions may be used for effecting treatment or prevention of a plurality of disease states caused by dysfunctional biochemical or biological pathways. The compositions and methods of this invention are particularly useful to identify novel therapeutic modulators of in-vivo receptor activity with extended half-lives and relevant bioactivity as compared to the naturally translated polypeptides upon which the analogs are derived.

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