公开(公告)号：US11739289B2

公开(公告)日：2023-08-29

申请号：US16854183

申请日：2020-04-21

申请人： Lonza Limited

发明人： Michael Mietzner ,  Richard Falk ,  Rajesh Beri ,  Mark Caswell

IPC分类号： B01F27/00 ,  C12M1/06 ,  B01F27/191 ,  B01F27/1125 ,  B01F101/44

CPC分类号： C12M27/02 ,  B01F27/1125 ,  B01F27/191 ,  B01F2101/44

摘要： An impeller is usable in a variable diameter bioreactor having multiple vessel sections of successively increasing or decreasing volume. The impeller includes an impeller blade extending along an impeller blade axis between first and second axial ends and having opposed impeller blade faces, an impeller blade leading edge, and an impeller blade trailing edge. Each of the leading and trailing edges defines a helix or spiral between the axial ends of the impeller blade. In certain arrangements, the impeller blade is one of at least two impeller blades joined together along an impeller shaft extending axially along the impeller blade axis mentioned, and the helix or spiral has a pitch approximately equal to one half of a length between the first and second axial ends.

公开(公告)号：US11597900B2

公开(公告)日：2023-03-07

申请号：US16406067

申请日：2019-05-08

申请人： Lonza Limited

发明人： Michael Mietzner ,  Rajesh Beri ,  Edward Gunderson

IPC分类号： C12M1/18 ,  C12M1/00 ,  C12M1/06 ,  C12P21/00 ,  C12M1/36

摘要： A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.

公开(公告)号：US10370629B2

公开(公告)日：2019-08-06

申请号：US15629886

申请日：2017-06-22

申请人： Lonza Limited

发明人： Michael Mietzner ,  Rajesh Beri ,  Edward Gunderson

IPC分类号： C12M1/00 ,  C12M1/06 ,  C12P21/00 ,  C12M1/36

摘要： A variable diameter bioreactor vessel is provided that includes a first vessel section having a first diameter configured to hold a liquid media and biologic material, and a second vessel section having a second diameter that is greater than the first diameter such that the liquid media can be increased from a first volume to a second volume within the vessel.