公开(公告)号：US20240342055A1

公开(公告)日：2024-10-17

申请号：US18752794

申请日：2024-06-25

申请人： ALPHINITY USA, INC.

发明人： Michael C. Gagne

IPC分类号： A61J1/10 ,  A61J1/14 ,  B01F27/61 ,  B01F27/71 ,  B01F27/91 ,  B01F35/513 ,  B01F35/75 ,  B01F101/44 ,  C12M1/00 ,  C12M1/06 ,  C12M3/00 ,  F04B43/06 ,  F04D1/00 ,  F04D29/40

CPC分类号： A61J1/10 ,  B01F27/61 ,  B01F27/71 ,  B01F27/91 ,  B01F35/513 ,  B01F35/7544 ,  C12M23/14 ,  C12M23/46 ,  C12M27/02 ,  C12M29/10 ,  F04D1/00 ,  F04D29/40 ,  A61J1/1481 ,  B01F2101/44 ,  F04B43/06

摘要： A method of pumping fluid out of a bioprocess vessel includes providing a bioprocess vessel defining an interior volume and having a bottom surface containing an aperture or port therein for the passage of fluid and a pump head integrally formed with or bonded to the bottom surface of the bioprocess vessel or secured to the port, wherein the pump head further comprises an inlet and an outlet with the inlet in fluid communication with the interior volume, the pump head further including a plurality of diaphragms, each diaphragm associated with a check-valve, wherein sequential actuation of the plurality of diaphragms pumps fluid from the interior volume of the bioprocess vessel into the inlet and out of the outlet. The plurality of diaphragms are actuated with a motor secured to the pump head. In other embodiments, the pump head is secured to the bioprocess vessel with fasteners.

公开(公告)号：US20240253000A1

公开(公告)日：2024-08-01

申请号：US18416692

申请日：2024-01-18

申请人： Levitronix GmbH

发明人： Thomas HOLENSTEIN ,  Nils SCHLEGEL ,  Florian WASSMER

IPC分类号： B01F35/32 ,  B01F27/808 ,  B01F27/90 ,  B01F33/453 ,  B01F35/511 ,  B01F35/513 ,  B01F101/22 ,  B01F101/44 ,  C12M1/00 ,  C12M1/06

CPC分类号： B01F35/3213 ,  B01F27/808 ,  B01F27/90 ,  B01F33/453 ,  B01F35/511 ,  B01F35/513 ,  C12M23/28 ,  C12M27/02 ,  B01F2101/22 ,  B01F2101/44 ,  B01F2215/0422

摘要： A mixing device for mixing at least two substances includes a single-use device and a reusable device. The single-use device includes an impeller, vanes, and a cup for receiving the rotor housing. A magnetically effective core is in the rotor housing. The reusable device includes a stator to contactlessly magnetically drive the impeller about the axis of rotation and magnetically levitate the impeller with respect to the stator. A plurality of stabilizing elements is on the impeller for stabilizing the impeller against tilting. Each stabilizing element is arranged between two vanes and extends from a radial inner edge to a radial outer edge with respect to the radial direction, and each radial outer edge has a distance from the axis of rotation which is smaller than half the outer diameter of the impeller.

公开(公告)号：US11739289B2

公开(公告)日：2023-08-29

申请号：US16854183

申请日：2020-04-21

申请人： Lonza Limited

发明人： Michael Mietzner ,  Richard Falk ,  Rajesh Beri ,  Mark Caswell

IPC分类号： B01F27/00 ,  C12M1/06 ,  B01F27/191 ,  B01F27/1125 ,  B01F101/44

CPC分类号： C12M27/02 ,  B01F27/1125 ,  B01F27/191 ,  B01F2101/44

摘要： An impeller is usable in a variable diameter bioreactor having multiple vessel sections of successively increasing or decreasing volume. The impeller includes an impeller blade extending along an impeller blade axis between first and second axial ends and having opposed impeller blade faces, an impeller blade leading edge, and an impeller blade trailing edge. Each of the leading and trailing edges defines a helix or spiral between the axial ends of the impeller blade. In certain arrangements, the impeller blade is one of at least two impeller blades joined together along an impeller shaft extending axially along the impeller blade axis mentioned, and the helix or spiral has a pitch approximately equal to one half of a length between the first and second axial ends.

公开(公告)号：US12077742B2

公开(公告)日：2024-09-03

申请号：US16853865

申请日：2020-04-21

申请人： Life Technologies Corporation

发明人： Nephi D. Jones ,  Christopher D. Brau

IPC分类号： C12M1/06 ,  B01F27/1111 ,  B01F27/191 ,  B01F27/2111 ,  B01F35/41 ,  B01F35/513 ,  B01F101/44 ,  C12M1/00 ,  C12M1/02 ,  C12N1/00

CPC分类号： C12M27/02 ,  B01F27/1111 ,  B01F27/191 ,  B01F27/2111 ,  B01F35/4121 ,  B01F35/513 ,  C12M1/007 ,  C12M1/02 ,  C12M23/14 ,  C12N1/00 ,  B01F2101/44

摘要： A method for mixing a biological suspension includes disposing a biological suspension within a compartment of a container, the biological suspension comprising cells or microorganisms suspended within a nutrient growth medium; and rotating a first drive line and laterally spaced apart second drive line within the compartment of the container so as to cause the drive lines to twist into a helical configuration and mix the biological suspension.

公开(公告)号：US11939561B2

公开(公告)日：2024-03-26

申请号：US16438815

申请日：2019-06-12

申请人： Sartorius Stedim Biotech GmbH

发明人： Diana Kronenberg

IPC分类号： B65B5/04 ,  B01F27/072 ,  B01F27/191 ,  B01F27/88 ,  B01F27/91 ,  B01F33/453 ,  B01F35/513 ,  B65B25/00 ,  B65D6/24 ,  B65D19/38 ,  B65D19/40 ,  B65D77/00 ,  B65D77/04 ,  C12M1/00 ,  C12M1/12 ,  B01F101/44

CPC分类号： C12M23/26 ,  B01F27/0723 ,  B01F27/0724 ,  B01F27/191 ,  B01F27/88 ,  B01F27/91 ,  B01F33/4531 ,  B01F35/513 ,  B65B5/04 ,  B65B25/00 ,  B65D11/1873 ,  B65D19/385 ,  B65D19/40 ,  B65D77/003 ,  B65D77/0466 ,  C12M23/14 ,  C12M23/28 ,  C12M25/06 ,  B01F2101/44 ,  B65D2519/00532

摘要： A packaging for a flexible container, in particular for a disposable bag for use in a bioreactor, including a bottom part for fixing a first portion of the container, a ceiling part for fixing an opposite second portion of the container, a receiving space which on a first side is defined by the bottom part and on an opposite second side is defined by the ceiling part, and struts arranged between the bottom part and the ceiling part, which fix a defined distance between the bottom part and the ceiling part.

公开(公告)号：US20240042397A1

公开(公告)日：2024-02-08

申请号：US18257201

申请日：2021-12-17

申请人： DSM IP Assets B.V.

发明人： Ivan de Jesus GAYTAN PEREZ ,  Stewart Terrence MITCHARD ,  Adam SMITH

IPC分类号： B01F21/00 ,  B01F21/20 ,  B01F23/50 ,  B01F25/50 ,  B01F35/71 ,  B01F35/88 ,  B01F35/13

CPC分类号： B01F21/30 ,  B01F21/20 ,  B01F23/59 ,  B01F23/56 ,  B01F25/50 ,  B01F35/71731 ,  B01F35/71785 ,  B01F35/881 ,  B01F35/13 ,  B01F2101/44

摘要： The present invention relates to apparatus for manufacturing at least one liquid, by dissolving or suspending powders in solvents. The apparatus may be arranged for inclusion in a pellet coating system to supply the liquid to a downstream apparatus such as a Post Pellet Liquid Application (PPLA, 44). The apparatus includes: a mixing system, comprising a mixing pump (27), a mixing vessel (33) and piping for mixing substances located in the mixing vessel (33) by liquid recirculation; solvent supply means, comprising a supply tank (37) arranged to supply solvent to the mixing vessel (33); a feeding system, comprising a Hopper (32) for storing a first particulate material, a ramp arranged above a weighing tray (34) and a hopper vibrator (3.1) for feeding a first particulate material to the weighing tray (34); a weighing system located above the mixing vessel (33), the weighing system comprising the weighing tray (34), a weighing tray loadcell (5) for weighting a first particulate material and a weighing tray vibrator (4) for feeding a first particulate material to the mixing vessel (33); a blending vessel (40) to which a liquid comprising the first particulate material is transferred from the mixing vessel (33) and to which additional solvent may be added to reach a desired concentration of the first particulate material in the liquid; optionally a day tank (39) to which a liquid comprising the first particulate material is transferred from the blending vessel (40.1) for storage; and a control system, wherein a Programmable Logic Controller (PLC) (25) is arranged to receive signals from the weighing system and to control operation of at least part of the feed system according to the signals received from the weighing system to deliver a target mass of first and at least a second particulate material to the mixing vessel (33). The apparatus for manufacturing at least one liquid according to the invention may be connected to system for coating pellets, such as feed pellets. The system for coating pellets may include: the apparatus for manufacturing at least one liquid; a pellet source; a pellet coating device; means for feeding at least one liquid from the manufacturing apparatus to the pellet coating device; wherein the pellet coating device is arranged to apply the or each liquid to at least some of the pellets received from the pellet source. The present invention includes a method for manufacturing a liquid, by dissolving or suspending powders in solvents.

公开(公告)号：US20240026272A1

公开(公告)日：2024-01-25

申请号：US18038552

申请日：2021-12-14

申请人： GLOBAL LIFE SCIENCES SOLUTIONS USA LLC

发明人： ANDREU FONTOVA SOSA ,  MAGNUS GRAHN ,  NICOLAS PETITFOURG

IPC分类号： C12M3/06 ,  B01F35/21

CPC分类号： C12M27/16 ,  B01F35/2117 ,  B01F2101/44

摘要： A rocking mechanism for a bioreactor vessel includes a base, a motor mounted to the base and having an eccentric roller driven by the motor, and a rocking plate in contact with the eccentric roller, the rocking plate being configured to receive a bioreactor vessel thereon. The motor is controllable to drive the eccentric roller to transmit a force against an underside of the rocking plate to tilt the rocking plate and bioreactor vessel.

公开(公告)号：US11654408B2

公开(公告)日：2023-05-23

申请号：US16421168

申请日：2019-05-23

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Trevor G. Williams

IPC分类号： B01F27/2111 ,  B01F35/513 ,  B01F35/41 ,  C12M1/02 ,  C12M1/00 ,  C12M1/10 ,  B01F27/07 ,  B01F27/2121 ,  B01F101/44

CPC分类号： B01F35/4111 ,  B01F27/071 ,  B01F27/2111 ,  B01F27/2121 ,  B01F35/513 ,  C12M1/007 ,  C12M1/02 ,  C12M1/10 ,  B01F2101/44

摘要： A method for operating a bioreactor includes passing a drive shaft into a first tubular connector and a second tubular connector projecting from the first tubular connector, the first tubular connector and the second tubular connector being at least partially disposed within a container, the first tubular connector being more flexible than the second tubular connector, the second tubular connector having a length that comprises at least 20% of a combined length of the first tubular connector and the second tubular connector. Rotating the drive shaft so as to rotate the first tubular connector and the second tubular connector within the container.

公开(公告)号：US12128367B2

公开(公告)日：2024-10-29

申请号：US16953066

申请日：2020-11-19

申请人： LIFE TECHNOLOGIES CORPORATION

发明人： Michael E. Goodwin ,  Nephi D. Jones ,  Derik R. West

IPC分类号： B01F23/23 ,  B01F23/231 ,  B01F35/513 ,  C12M1/00 ,  B01F101/44

CPC分类号： B01F23/23124 ,  B01F23/231241 ,  B01F35/513 ,  C12M23/14 ,  C12M23/26 ,  C12M23/40 ,  C12M29/06 ,  B01F23/23113 ,  B01F23/231151 ,  B01F23/231262 ,  B01F23/231266 ,  B01F23/231269 ,  B01F2101/44

摘要： A container assembly includes a flexible bag having an interior surface bounding a chamber and an opposing exterior surface. The bag has a bottom end wall that includes a first sparger and a second sparger. The first sparger and the second sparger each have a flexible first sheet overlying a flexible second sheet, the first sheet and the second sheet being secured together so as to form a sparging area bounded between the first sheet and the second sheet, at least a portion of the first sheet overlying the sparging area being gas permeable so that gas can pass from the sparging area, through the first sheet, and into the chamber.

公开(公告)号：US12060549B2

公开(公告)日：2024-08-13

申请号：US17156275

申请日：2021-01-22

申请人： UTS BIOGASTECHNIK GMBH

发明人： Andreas Czwaluk

IPC分类号： C12M1/06 ,  B01F27/25 ,  B01F27/704 ,  B01F27/705 ,  B01F27/706 ,  B01F33/81 ,  B01F35/212 ,  B01F35/22 ,  B01F35/221 ,  C12M1/107 ,  C12M1/34 ,  C12M1/36 ,  C12P1/00 ,  B01F101/44

CPC分类号： C12M27/02 ,  B01F27/25 ,  B01F27/704 ,  B01F27/705 ,  B01F27/706 ,  B01F33/81 ,  B01F35/212 ,  B01F35/2202 ,  B01F35/221422 ,  C12M21/04 ,  C12M41/42 ,  C12M41/48 ,  C12P1/00 ,  B01F2101/44 ,  Y02E50/30

摘要： A method for operating an agitating device and a digester, wherein the digester is filled with a substrate and an agitating device is in the digester. These steps are performed: a) A target load curve is lodged in the control device; b) the control device prescribes a target rotation speed; c) the control device operates the agitating device at an actual speed corresponding to a target speed; d) the control device captures an actual agitating device torque measurement value at the actual speed of rotation; e) the control device derives from the actual measurement value an actual characteristic value of the agitating device applied torque; f) the control device compares the derived actual characteristic value against the target characteristic value of the substrate resulting from the target load curve at the prescribed target speed; and g) the control device controls the agitating device in dependence on the result of comparison.