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公开(公告)号：US11613900B2
公开(公告)日：2023-03-28
申请号：US17553283
申请日：2021-12-16
申请人： LONZA LTD
摘要： A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. Each modular unit can be a fermentation unit, a pre-viral unit, a post-viral unit, a utility space, a warehouse, a media buffer facility, an office, a personnel unit, or another unit. The modular units can be arranged to maximize a number of modular units within the shell while minimizing a footprint of the shell. A method of assembling a facility for manufacturing at least one product includes providing at least one central unit and providing at least one modular unit in communication with the central unit(s) such that utilities are provided by the central unit(s) to the modular unit(s).
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公开(公告)号：US11377865B2
公开(公告)日：2022-07-05
申请号：US16883505
申请日：2020-05-26
申请人： LONZA LTD
发明人： Leander Biffiger , Sandra Carbonneau , Andre Collioud , Jonathan Fortin , Dominik Imbolden , Torsten Schmidt , Stefan Stoffel , Diego Studer , Christoph Vogel , Stefan Widmer , Tristan Wilkins , Lesley Wood , Alexander Zahiri
摘要： A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.
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公开(公告)号：US10689873B2
公开(公告)日：2020-06-23
申请号：US15659390
申请日：2017-07-25
申请人： LONZA LTD
发明人： Leander Biffiger , Sandra Carbonneau , Andre Collioud , Jonathan Fortin , Dominik Imbolden , Torsten Schmidt , Stefan Stoffel , Diego Studer , Christoph Vogel , Stefan Widmer , Tristan Wilkins , Lesley Wood , Alexander Zahiri
摘要： A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.
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公开(公告)号：US20240360398A1
公开(公告)日：2024-10-31
申请号：US18769485
申请日：2024-07-11
申请人： Lonza Ltd
发明人： John Gunst , Jonathan Fortin , Tristan Wilkins
摘要： The present disclosure is directed to the organic growth and phasing design for a system for the industrial growth of biologics. A system may include a number of subsystems, such as a buffer distribution subsystem, a media preparation subsystem, a bioreactor subsystem, a harvest subsystem, and/or a purification subsystem. The subsystems may be highly interconnected for flexible process flow design. Additionally, the subsystems may be constructed with a total output capacity with a total number of equipment stations and operated at a lower output capacity with fewer than the total equipment stations to maintain headroom for growth in phases.
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公开(公告)号：US12071607B2
公开(公告)日：2024-08-27
申请号：US16408819
申请日：2019-05-10
申请人： Lonza Ltd.
发明人： John Gunst , Jonathan Fortin , Tristan Wilkins
摘要： The present disclosure is directed to the organic growth and phasing design for a system for the industrial growth of biologics. A system may include a number of subsystems, such as a buffer distribution subsystem, a media preparation subsystem, a bioreactor subsystem, a harvest subsystem, and/or a purification subsystem. The subsystems may be highly interconnected for flexible process flow design. Additionally, the subsystems may be constructed with a total output capacity with a total number of equipment stations and operated at a lower output capacity with fewer than the total equipment stations to maintain headroom for growth in phases.
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公开(公告)号：US11236520B2
公开(公告)日：2022-02-01
申请号：US15455836
申请日：2017-03-10
申请人： LONZA LTD
摘要： A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. Each modular unit can be a fermentation unit, a pre-viral unit, a post-viral unit, a utility space, a warehouse, a media buffer facility, an office, a personnel unit, or another unit. The modular units can be arranged to maximize a number of modular units within the shell while minimizing a footprint of the shell. A method of assembling a facility for manufacturing at least one product includes providing at least one central unit and providing at least one modular unit in communication with the central unit(s) such that utilities are provided by the central unit(s) to the modular unit(s).
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公开(公告)号：US11859403B2
公开(公告)日：2024-01-02
申请号：US17826856
申请日：2022-05-27
申请人： LONZA LTD
发明人： Leander Biffiger , Sandra Carbonneau , Andre Collioud , Jonathan Fortin , Dominique Imboden , Torsten Schmidt , Stefan Stoffel , Diego Studer , Christoph Vogel , Stefan Widmer , Tristan Wilkins , Lesley Wood , Alexander Zahiri
摘要： A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.
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公开(公告)号：US20170321443A1
公开(公告)日：2017-11-09
申请号：US15659390
申请日：2017-07-25
申请人： LONZA LTD
发明人： Leander Biffiger , Sandra Carbonneau , Andre Collioud , Jonathan Fortin , Dominik Imbolden , Torsten Schmidt , Stefan Stoffel , Diego Studer , Christoph Vogel , Stefan Widmer , Tristan Wilkins , Lesley Wood , Alexander Zahiri
摘要： A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line.
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公开(公告)号：US20170260763A1
公开(公告)日：2017-09-14
申请号：US15455836
申请日：2017-03-10
申请人： LONZA LTD
摘要： A customizable facility for manufacturing at least one product has at least one modular unit in communication with at least one central unit configured to provide utilities to the at least one modular unit. In some embodiments, the central unit(s) and modular unit(s) are positioned at least partially within a shell. Each modular unit can be a fermentation unit, a pre-viral unit, a post-viral unit, a utility space, a warehouse, a media buffer facility, an office, a personnel unit, or another unit. The modular units can be arranged to maximize a number of modular units within the shell while minimizing a footprint of the shell. A method of assembling a facility for manufacturing at least one product includes providing at least one central unit and providing at least one modular unit in communication with the central unit(s) such that utilities are provided by the central unit(s) to the modular unit(s).
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