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    Buffer formulation method and system
    1.
    发明授权
    Buffer formulation method and system 有权

    公开(公告)号：US11965152B2

    公开(公告)日：2024-04-23

    申请号：US16783275

    申请日：2020-02-06

    申请人： Lonza Ltd.

    发明人： Thaddaeus Webster ,  Carrie Mason ,  Tristan Wilkins

    IPC分类号： C12M1/34 ,  B01F23/45 ,  B01J19/00 ,  B01F101/22

    CPC分类号： C12M41/26 ,  B01F23/45 ,  B01J19/0086 ,  C12M1/3407 ,  C12M1/3453 ,  C12M41/12 ,  B01F2101/22 ,  Y10T436/108331

    摘要： The monitoring and control of bioprocesses is provided. More particularly, the present disclosure is directed to formulating buffer products from multiple buffer solutions for feeding the different operations occurring within a bioprocess line. As the buffer product is being formulated, the buffer product is tested for conductivity, refractive index, and optionally pH. The conductivity measurements are used in conjunction with refractive index measurements to ensure that the buffer product not only has the correct concentration of ions but also has the correct concentration of components. A controller can be used to make automatic adjustments to the buffer product should any of the measured parameters fall outside a preset range.

    Midscale Model For Organic Growth and Phasing
    5.
    发明公开
    Midscale Model For Organic Growth and Phasing 审中-公开

    公开(公告)号：US20240360398A1

    公开(公告)日：2024-10-31

    申请号：US18769485

    申请日：2024-07-11

    申请人： Lonza Ltd

    发明人： John Gunst ,  Jonathan Fortin ,  Tristan Wilkins

    IPC分类号： C12M1/00 ,  C12M1/26

    CPC分类号： C12M29/10 ,  C12M1/005 ,  C12M1/26 ,  C12M21/00 ,  C12M23/58 ,  C12M47/10 ,  C12M47/12

    摘要： The present disclosure is directed to the organic growth and phasing design for a system for the industrial growth of biologics. A system may include a number of subsystems, such as a buffer distribution subsystem, a media preparation subsystem, a bioreactor subsystem, a harvest subsystem, and/or a purification subsystem. The subsystems may be highly interconnected for flexible process flow design. Additionally, the subsystems may be constructed with a total output capacity with a total number of equipment stations and operated at a lower output capacity with fewer than the total equipment stations to maintain headroom for growth in phases.

    Midscale model for organic growth and phasing
    6.
    发明授权
    Midscale model for organic growth and phasing 有权

    公开(公告)号：US12071607B2

    公开(公告)日：2024-08-27

    申请号：US16408819

    申请日：2019-05-10

    申请人： Lonza Ltd.

    发明人： John Gunst ,  Jonathan Fortin ,  Tristan Wilkins

    IPC分类号： C12M1/00 ,  C12M1/26

    CPC分类号： C12M29/10 ,  C12M1/005 ,  C12M1/26 ,  C12M21/00 ,  C12M23/58 ,  C12M47/10 ,  C12M47/12

    摘要： The present disclosure is directed to the organic growth and phasing design for a system for the industrial growth of biologics. A system may include a number of subsystems, such as a buffer distribution subsystem, a media preparation subsystem, a bioreactor subsystem, a harvest subsystem, and/or a purification subsystem. The subsystems may be highly interconnected for flexible process flow design. Additionally, the subsystems may be constructed with a total output capacity with a total number of equipment stations and operated at a lower output capacity with fewer than the total equipment stations to maintain headroom for growth in phases.

    Method and system for providing buffer solutions
    7.
    发明授权
    Method and system for providing buffer solutions 审中-公开

    公开(公告)号：US10669518B2

    公开(公告)日：2020-06-02

    申请号：US15667387

    申请日：2017-08-02

    申请人： LONZA LTD

    发明人： Tristan Wilkins

    IPC分类号： B67D7/00 ,  C12M1/34 ,  C12M1/12 ,  C12M3/00 ,  C12M1/00 ,  B67D7/02

    摘要： A method for delivering a processing solution includes providing a concentrated processing solution in a bioprocess container, the concentrated processing solution being produced at a first site. The method also includes combining the concentrated processing solution with a biopolymer containing solution produced in a bioreactor at a second site different from the first site. In some embodiments, the processing solution is a buffer for processing products of cells cultured in a bioreactor. A system and a pharmaceutical production facility for carrying out the method is also provided.

    Buffer Formulation Method and System
    9.
    发明申请
    Buffer Formulation Method and System 审中-公开

    公开(公告)号：US20200255792A1

    公开(公告)日：2020-08-13

    申请号：US16783275

    申请日：2020-02-06

    申请人： Lonza Ltd.

    发明人： Thaddaeus Webster ,  Carrie Mason ,  Tristan Wilkins

    IPC分类号： C12M1/34 ,  G01N35/00

    摘要： The monitoring and control of bioprocesses is provided. More particularly, the present disclosure is directed to formulating buffer products from multiple buffer solutions for feeding the different operations occurring within a bioprocess line. As the buffer product is being formulated, the buffer product is tested for conductivity, refractive index, and optionally pH. The conductivity measurements are used in conjunction with refractive index measurements to ensure that the buffer product not only has the correct concentration of ions but also has the correct concentration of components. A controller can be used to make automatic adjustments to the buffer product should any of the measured parameters fall outside a preset range.