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公开(公告)号：US5792104A
公开(公告)日：1998-08-11
申请号：US761965
申请日：1996-12-10
CPC分类号： A61M39/0208 , A61M2039/0211 , A61M2039/0214 , A61M2039/0226 , A61M5/1408
摘要： A subcutaneously implantable vascular access port includes a base which defines a plurality of fluid cavities separated by a dividing wall configured to provide an outlet duct for each fluid cavity, wherein the outlet ducts are staggered along the length of the dividing wall, a cap configured to receive the base and which includes a plurality of septum access apertures aligned with the fluid cavities, and a single self-sealing septum captured between the cap and the base. An outlet stem exits the base and communicates with the fluid cavities therein. The outlet stem has two prongs formed in a side-by-side configuration extending outwardly from the base. Fluid injected into a fluid cavity through the septum flows through a smooth transition region in which the cross-sectional area is smoothly reduced from the corresponding fluid cavity. A locking sleeve provides radial inward pressure upon the catheter which is slid over the outlet stem, thereby insuring that the catheter remains mounted on the outlet stem.
摘要翻译： 皮下可植入的血管通路口包括基部，其限定由分隔壁分隔的多个流体空腔，该分隔壁被配置成为每个流体腔提供出口管，其中出口管沿着分隔壁的长度交错， 接收底座并且包括与流体空腔对准的多个隔膜通路孔，以及捕获在盖和基座之间的单个自密封隔膜。 出口杆离开基座并与其中的流体腔连通。 出口杆具有从基部向外延伸的并排构造形成的两个尖头。 通过隔膜注入流体腔的流体流过平滑过渡区域，其中横截面积从相应的流体腔平滑地减小。 锁定套筒在导管上提供径向向内的压力，其在出口杆上滑动，从而确保导管保持安装在出口杆上。
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公开(公告)号：US5738666A
公开(公告)日：1998-04-14
申请号：US678669
申请日：1996-07-10
CPC分类号： A61M27/006 , A61B1/00135 , A61B1/00165 , A61M25/0009 , A61M25/0074 , A61M25/0068 , A61M25/007
摘要： A partially disposable instrument for use in a medical procedure includes a rigid introducer assembly and a fiber-optic endoscope having a flexible shaft which may be removably inserted through the introducer assembly. The introducer assembly permits a fluid to be flushed therethrough and about the shaft such that the fluid exits through a terminal end of the introducer assembly. The instrument may be utilized in connection with a method for positioning a catheter within a body during a medical procedure, including the steps of placing the catheter over the introducer, inserting the shaft of the endoscope through the introducer, advancing the catheter, introducer and endoscope shaft into the body as a unit, positioning the catheter within the body utilizing the fiber-optic endoscope, and removing the endoscope shaft and the introducer from the body while leaving the catheter in place. The catheter includes a slit tip capable of opening to permit the terminal end of the introducer assembly to pass therethrough such that the diameter of the slit tip, when so configured, is not significantly greater than a nominal diameter of the catheter.
摘要翻译： 用于医疗过程的部分一次性器具包括刚性导引器组件和具有柔性轴的光纤内窥镜，该柔性轴可通过导引器组件可移除地插入。 导引器组件允许流体通过其中并且围绕轴被冲洗，使得流体通过导引器组件的终端排出。 该仪器可以用于在医疗过程期间将导管定位在体内的方法，包括以下步骤：将导管放置在导引器上，将内窥镜的轴插入导引器，推进导管，导入器和内窥镜 轴作为一个单元进入身体，使用光纤内窥镜将导管定位在体内，并且在将导管放置就位的同时从身体移除内窥镜轴和导引器。 导管包括能够打开以允许导引器组件的终端穿过其中的狭缝尖端，使得当构造时狭缝尖端的直径不显着大于导管的公称直径。
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公开(公告)号：US08414524B2
公开(公告)日：2013-04-09
申请号：US11641490
申请日：2006-12-19
CPC分类号： A61M25/008 , A61M25/0068 , A61M25/0136 , A61M25/0147 , A61M25/10 , A61M2025/015 , A61M2025/1079 , A61M2025/1093
摘要： The long nose manipulatable catheter includes a main lumen, a wire lumen with a push-pull wire therethrough, and a flexible joint region. The catheter section includes a control including a handle and a wire control member engaging the push-pull wire for manipulating the flexible joint region. The push-pull wire may be tapered, having a proximal portion of a first diameter and a smaller diameter distal portion. A coil may be placed around the smaller diameter to prevent buckling of the smaller diameter portion. A strapping coil may also disposed around the outside of the catheter, and an outer covering may be disposed around the strapping coil. An outer covering of a mesh may also be disposed around the distal tip of the catheter.
摘要翻译： 长鼻子可操纵导管包括主腔，具有穿过其中的推拉线的丝腔以及柔性关节区。 导管部分包括一个控制装置，该控制装置包括把手和一个接合推挽线的线控制件，用于操纵柔性接头区域。 推拉线可以是锥形的，具有第一直径的近端部分和较小直径的远端部分。 线圈可以放置在较小直径周围以防止较小直径部分的弯曲。 捆扎线圈也可以设置在导管的外部周围，并且外覆盖物可以设置在捆扎线圈周围。 网的外覆盖物也可以设置在导管的远侧末端周围。
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公开(公告)号：US5800376A
公开(公告)日：1998-09-01
申请号：US826782
申请日：1997-04-07
申请人： David A. Watson , Paul S. Vaskelis
发明人： David A. Watson , Paul S. Vaskelis
CPC分类号： A61M27/006
摘要： A surgically implantable flow control device positionable over a burr-hole through a patient's skull is provided for use in shunt systems for controlling the release of entrapped body fluids. The device includes a rigid base including an inlet port and a valve seat which surrounds the inlet port, and a flow control member secured to the base. The flow control member has an asymmetric membrane which is resiliently biased to contact the valve seat in a manner forming a releasible seal therebetween, to provide controlled resistance to proximal-to-distal fluid flow through the device. The membrane includes a septum portion overlying the inlet port and a relatively thin portion responsive to fluid pressure differentials on inlet and outlet sides thereof. A membrane shield overlies an outlet side of the membrane and includes a needle guide aperture in alignment with the septum portion of the membrane and the inlet port.
摘要翻译： 提供了一种通过患者颅骨定位在钻孔上方的可手术植入的流量控制装置，用于分流系统中用于控制截留体液的释放。 该装置包括刚性基座，其包括入口端口和围绕入口端口的阀座，以及固定到基座的流量控制构件。 流动控制构件具有不对称膜，其被弹性地偏压以在其间形成可释放密封的方式接触阀座，以提供对通过该装置的近端至远端流体流动的受控阻力。 膜包括覆盖入口端口的隔膜部分和响应于其入口侧和出口侧上的流体压力差的相对较薄的部分。 膜屏蔽覆盖膜的出口侧，并且包括与膜的隔膜部分和入口对准的针引导孔。
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公开(公告)号：US5662600A
公开(公告)日：1997-09-02
申请号：US536651
申请日：1995-09-29
申请人： David A. Watson , Paul S. Vaskelis
发明人： David A. Watson , Paul S. Vaskelis
CPC分类号： A61M27/006
摘要： A surgically implantable flow control device positionable over a burr-hole through a patient's skull is provided for use in shunt systems for controlling the release of entrapped body fluids. The device includes a rigid base including an inlet port and a valve seat which surrounds the inlet port, and a flow control member secured to the base. The flow control member has an asymmetric membrane which is resiliently biased to contact the valve seat in a manner forming a releasible seal therebetween, to provide controlled resistance to proximal-to-distal fluid flow through the device. The membrane includes a septum portion overlying the inlet port and a relatively thin portion responsive to fluid pressure differentials on inlet and outlet sides thereof. A membrane shield overlies an outlet side of the membrane and includes a needle guide aperture in alignment with the septum portion of the membrane and the inlet port.
摘要翻译： 提供了一种通过患者颅骨定位在钻孔上方的可手术植入的流量控制装置，用于分流系统中用于控制截留体液的释放。 该装置包括刚性基座，其包括入口端口和围绕入口端口的阀座，以及固定到基座的流量控制构件。 流动控制构件具有不对称膜，其被弹性地偏压以在其间形成可释放密封的方式接触阀座，以提供对通过该装置的近端至远端流体流动的受控阻力。 膜包括覆盖入口端口的隔膜部分和响应于其入口侧和出口侧上的流体压力差的相对较薄的部分。 膜屏蔽覆盖膜的出口侧，并且包括与膜的隔膜部分和入口对准的针引导孔。
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公开(公告)号：US5387188A
公开(公告)日：1995-02-07
申请号：US59897
申请日：1993-05-10
申请人： David A. Watson
发明人： David A. Watson
CPC分类号： A61M27/006
摘要： In a cerebrospinal fluid shunt including a flow control device forming a portion of a fluid conduit, a capacitive element is provided for reducing overdrainage of cerebrospinal fluid due to the pulsatile nature of cerebrospinal fluid flow. The capacitive element includes a reservoir having a base and a housing for the base which cooperatively define a fluid flow pathway through the reservoir. A pair of spaced, substantially parallel, flexible diaphragms form opposite sides of the housing such that each flexible diaphragm has an outer surface which forms an exterior surface of the reservoir, and an inner surface in contact with and subject to pressure variations of cerebrospinal fluid within the reservoir. A raised ring surrounds each diaphragm and forms a recess in which the respective diaphragm is positioned. The capacitive element accommodates the pulsatile nature of cerebrospinal fluid flow between a cerebrospinal fluid source and the flow control valve by varying the fluid capacity of the reservoir.
摘要翻译： 在包括形成流体导管的一部分的流量控制装置的脑脊液分流器中，提供电容元件用于由于脑脊液流动的脉动特性而减少脑脊液的过量排出。 电容元件包括具有基座和用于基座的壳体的储存器，其协作地限定通过储存器的流体流动路径。 一对间隔的基本上平行的柔性隔膜形成壳体的相对侧，使得每个柔性隔膜具有形成储存器外表面的外表面，以及与脑脊液内压力变化接触并受其影响的内表面 水库。 凸起的环围绕每个隔膜并形成凹槽，相应的隔膜位于该凹槽中。 电容元件通过改变储存器的流体容量来适应脑脊液源和流量控制阀之间的脑脊液流的脉动特性。
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公开(公告)号：US5137529A
公开(公告)日：1992-08-11
申请号：US679658
申请日：1991-04-02
IPC分类号： A61M39/02
CPC分类号： A61M39/0208 , A61M2039/0072 , A61M2039/0229 , A61M2039/0241 , A61M2205/32 , Y10S128/12
摘要： A subcutaneously implantable injection port includes an elastomeric outer housing which encloses an easily assemblage multi-piece rigid base structure. An injection chamber is defined between an upper septum, formed integrally with the elastomeric outer housing, and the underlying base structure. The outer housing includes an upper dome and a lower reinforced sheet. The septum, which is formed integrally with the upper dome, includes a septum flange which is compressed, interiorly of the outer housing, between two base members. A filter extends across the injection chamber dividing it into upper and lower portions. A needle guard, provided by one of the base components, prevents contact between a needle inserted into the injection chamber and the filter. An outlet connector integrally formed with one of the base components extends through the outer housing for connecting a catheter or the like, with the lower portion of the injection chamber. In assembling the injection port, a first base member or rigid outer ring is placed adjacent to an interior surface of the elastomeric outer housing. A filter is placed within a second base member and held securely in place thereon by a third base member which provides the needle guard and fits within the second base member in an interference fit. This assembly is pushed into the first base member in a manner compressing the septum flange and creating a fluid-tight injection chamber.
摘要翻译： 皮下可植入的注射口包括弹性体外壳，其包围容易组装的多片刚性基底结构。 注射室限定在与弹性体外壳一体形成的上隔膜和下面的基础结构之间。 外壳包括上穹顶和下加强片。 与上部圆顶一体形成的隔膜包括在两个基部构件之间被压缩在外部壳体内部的隔膜凸缘。 过滤器延伸穿过注射室，将其分成上部和下部。 由一个基本部件提供的针护罩防止插入注射室中的针与过滤器之间的接触。 与其中一个基座部件整体形成的出口连接件延伸穿过外壳体，用于连接导管等与注射室的下部。 在组装注射口时，第一底部构件或刚性外环邻近弹性体外壳的内表面放置。 过滤器放置在第二基座构件内并且通过提供针护罩的第三基座构件牢固地保持在适当位置，并以过盈配合装配在第二基座构件内。 该组件以压缩隔膜凸缘并产生流体密封的注射室的方式被推入第一基件。
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公开(公告)号：US4969153A
公开(公告)日：1990-11-06
申请号：US365874
申请日：1989-07-24
摘要： A laser power supply includes a support member in which is mounted a laser tube for outputting a laser light beam and a printed circuit board containing the power supply circuits. A slidably mounted cover member encloses the support member and the laser tube and includes a pair of lens members for diverging and attenuating the laser light beam. A pair of spring clip members mounted on the support member releasable secure the laser tube to the support member while electrically connecting the laser tube to the printed circuit board.
摘要翻译： 激光电源包括支撑构件，其中安装有用于输出激光束的激光管和包含电源电路的印刷电路板。 可滑动安装的盖构件包围支撑构件和激光管，并且包括用于发散和衰减激光束的一对透镜构件。 安装在支撑构件上的一对弹簧夹构件可释放地将激光管固定到支撑构件，同时将激光管电连接到印刷电路板。
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公开(公告)号：US20150273193A1
公开(公告)日：2015-10-01
申请号：US14738438
申请日：2015-06-12
申请人： David A. Watson
发明人： David A. Watson
IPC分类号： A61M27/00
CPC分类号： A61M27/006 , A61B17/00
摘要： An improved shunt valve for the control of hydrocephalus provides for physiological atmospherically-referenced siphon control that is not adversely affected by overlying tissue. The valve includes one or more porous outer anti-fouling membranes to protect the flow control membranes from external mechanical tissue pressure, while permitting free movement of the flow control moveable membranes and permitting positive inlet pressure to regulate flow through the improved fluid shunt valve of the invention. The porous membranes are configured to prevent tissue ingrowth into the membranes pores while allowing adequate fluid flow across so as not to inhibit movement of the movable membrane.
摘要翻译： 用于控制脑积水的改进的分流阀提供生理大气参考的虹吸控制，其不受上覆组织的不利影响。 该阀包括一个或多个多孔外部防污膜，以保护流量控制膜免受外部机械组织压力，同时允许流动控制可移动膜的自由运动并且允许正入口压力来调节通过改进的流体分流阀 发明。 多孔膜被配置为防止组织向内生成膜孔，同时允许足够的流体流过，以便不会阻止活动膜的运动。
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公开(公告)号：US08871241B2
公开(公告)日：2014-10-28
申请号：US10714549
申请日：2003-11-13
申请人： Kang-Jye Chou , Hong Guo , Paul Ashton , Robert W. Shimizu , David A. Watson
发明人： Kang-Jye Chou , Hong Guo , Paul Ashton , Robert W. Shimizu , David A. Watson
CPC分类号： A61K9/0004 , A61K9/0024 , A61K9/0051 , A61K9/0092 , A61K9/204 , A61K9/2086 , A61K9/209 , A61K9/284 , A61K9/2853 , A61K9/2886 , A61K31/58 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： An injectable drug delivery device includes a core containing one or more drugs and one or more polymers. The core may be surrounded by one or more polymer outer layers (referred to herein as “coatings,” “skins,” or “outer layers”). In certain embodiments, the device is formed by extruding or otherwise preforming a polymeric skin for a drug core. The drug core may be co-extruded with the skin, or inserted into the skin after the skin has been extruded, and possibly cured. In other embodiments, the drug core may be coated with one or more polymer coatings. These techniques may be usefully applied to fabricate devices having a wide array of drug formulations and skins that can be selected to control the release rate profile and various other properties of the drugs in the drug core in a form suitable for injection using standard or non-standard gauge needles. The device may be formed by combining at least one polymer, at least one drug, and at least one liquid solvent to form a liquid suspension or solution wherein, upon injection, such suspension or solution under goes a phase change and forms a gel. The configuration may provide for controlled release of the drug(s) for an extended period.
摘要翻译： 可注射药物递送装置包括含有一种或多种药物的核心和一种或多种聚合物。 芯可以被一个或多个聚合物外层（本文中称为“涂层”，“表皮”或“外层”）包围。 在某些实施方案中，通过挤出或以其它方式预先形成用于药物核心的聚合物皮肤来形成装置。 药物核心可以与皮肤共挤出，或者在皮肤挤出后可以将其插入皮肤中，并可能固化。 在其它实施方案中，药物核心可以涂覆有一种或多种聚合物涂层。 这些技术可以有效地应用于制造具有广泛的药物制剂和皮肤的装置，其可以选择为以适合于使用标准或非标准的注射剂的形式控制药物核心中的药物的释放速率分布和各种其它性质， 标准规格针。 该装置可以通过组合至少一种聚合物，至少一种药物和至少一种液体溶剂以形成液体悬浮液或溶液而形成，其中在注射时，这样的悬浮液或溶液在变相下形成凝胶。 该配置可以提供长时间的药物的控制释放。
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