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公开(公告)号：US20140295407A1
公开(公告)日：2014-10-02
申请号：US14228170
申请日：2014-03-27
Applicant: Los Alamos National Security, LLC
Inventor： Basil I. Swanson , Harshini Mukundan , Anu Chaudhary
IPC: G01N33/569
CPC classification number: G01N33/56911 , G01N33/56938 , G01N33/56983
Abstract: Described herein are biosensors for early, pre-symptomatic detection of infectious agents and methods for their use. In particular, this disclosure describes biosensors that utilize toll-like receptor (TLR) binding domains to detect pathogen-associated molecular patterns (PAMPs). Also provided herein are methods of detecting and/or capturing a PAMP from a biological sample using the disclosed biosensors.
Abstract translation: 本文描述了用于早期，预先有症状地检测感染因子的生物传感器及其使用方法。 特别地，本公开描述了利用体外受体（TLR）结合域来检测病原体相关分子模式（PAMP）的生物传感器。 本文还提供了使用所公开的生物传感器从生物样品检测和/或捕获PAMP的方法。
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公开(公告)号：US20170307604A1
公开(公告)日：2017-10-26
申请号：US15640865
申请日：2017-07-03
Applicant: Los Alamos National Security, LLC
Inventor： Harshini Mukundan , Jessica Kubicek-Sutherland , Shailja Jakhar , Aneesa Noormohamed , Basil I. Swanson , Rama Murthy Sakamuri , Loreen Stromberg
IPC: G01N33/554 , G01N33/569 , C12Q1/68 , C12M1/34 , G01N33/58 , C12M1/00
CPC classification number: G01N33/554 , C12M1/00 , C12M1/34 , C12Q1/68 , G01N33/569 , G01N33/58 , G01N2405/00 , G01N2610/00
Abstract: Systems for and methods of capturing, detecting, quantifying, and characterizing target moieties that are characterized by having a lipophilic portion of sufficient size and chemical composition whereby the target moiety inserts (or partitions) into a lipid assembly are described. Methods of diagnosing a subject as having a bacterial infection by detecting bacterial pathogen associated molecular pattern (PAMP) molecules in serum are further described.
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公开(公告)号：US09255923B2
公开(公告)日：2016-02-09
申请号：US14317378
申请日：2014-06-27
Applicant: Los Alamos National Security, LLC
Inventor： Harshini Mukundan , Hongzhi Xie , Basil I. Swanson , Jennifer Martinez , Wynne K. Grace
IPC: G01N33/551 , G01N33/569 , G01N33/543 , G01N21/552 , G01N21/77
CPC classification number: G01N33/569 , G01N21/553 , G01N21/774 , G01N33/54373 , G01N2469/00
Abstract: The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel.
Abstract translation: 本发明通过夹心测定方法或脂质插入方法来解决多个生物分子的同时检测和定量测量，例如病原体生物标志物。 本发明可以进一步采用每个通道具有多传感器元件的多通道结构。
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公开(公告)号：US20140370532A1
公开(公告)日：2014-12-18
申请号：US14317378
申请日：2014-06-27
Applicant: Los Alamos National Security, LLC
Inventor： Harshini Mukundan , Hongzhi Xie , Basil I. Swanson , Jennifer Martinez , Wynne K. Grace
IPC: G01N33/569
CPC classification number: G01N33/569 , G01N21/553 , G01N21/774 , G01N33/54373 , G01N2469/00
Abstract: The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel.
Abstract translation: 本发明通过夹心测定方法或脂质插入方法来解决多个生物分子的同时检测和定量测量，例如病原体生物标志物。 本发明可以进一步采用每个通道具有多传感器元件的多通道结构。
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