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1.发明授权ZAP-70 expression as a marker for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) 有权ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物公开(公告)号：US07329502B2
公开(公告)日：2008-02-12
申请号：US10309548
申请日：2002-12-03
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein.
摘要翻译： 已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。 特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。 提供了通过确定受试者是否过表达ZAP-70 mRNA mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。
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2.发明授权ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) 有权ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物公开(公告)号：US07981610B2
公开(公告)日：2011-07-19
申请号：US11955322
申请日：2007-12-12
IPC分类号： C12Q1/68
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
摘要翻译： 已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。 特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。 提供了通过确定受试者是否过表达ZAP-70 mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。
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3.发明申请ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) 有权ZAP-70表达作为慢性淋巴细胞淋巴瘤/小淋巴细胞淋巴瘤（CLL / SLL）的标记物公开(公告)号：US20080227741A1
公开(公告)日：2008-09-18
申请号：US11955322
申请日：2007-12-12
IPC分类号： A61K31/7088 , C12Q1/68 , A61P35/02
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
摘要翻译： 已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。 特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。 提供了通过确定受试者是否过表达ZAP-70 mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。
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4.发明授权ZAP-70 expression as a marker for chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL) 有权ZAP-70表达作为慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL / SLL）的标记物公开(公告)号：US08748114B2
公开(公告)日：2014-06-10
申请号：US13155198
申请日：2011-06-07
IPC分类号： G01N33/574
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA or protein.
摘要翻译： 已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。 特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。 提供了通过确定受试者是否过表达ZAP-70 mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。
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5.发明申请ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) 有权ZAP-70表达作为慢性淋巴细胞淋巴瘤/小淋巴细胞淋巴瘤（CLL / SLL）的标记物公开(公告)号：US20110236915A1
公开(公告)日：2011-09-29
申请号：US13155198
申请日：2011-06-07
CPC分类号： G01N33/57426 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein.
摘要翻译： 已经令人惊奇地发现，在蛋白质和mRNA水平上的ZAP-70表达指示CLL / SLL患者的临床亚组。 特别地，高ZAP-70表达指示Ig-未突变的CLL / SLL。 提供了通过确定受试者是否过表达ZAP-70 mRNA mRNA或蛋白质来区分CLL / SLL的临床亚组的方法。
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6.发明申请公开(公告)号：US20120225793A1
公开(公告)日：2012-09-06
申请号：US13409416
申请日：2012-03-01
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M. Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zetti , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
IPC分类号： C40B30/04
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G16B25/00 , G16B40/00 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译： 基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。 此外，基因表达数据可用于开发更准确的生存预测因子。 本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。 本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。 本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。 该信息将有助于开发与特定受试者一起使用的治疗方法。
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7.发明授权公开(公告)号：US08131475B2
公开(公告)日：2012-03-06
申请号：US11493387
申请日：2006-07-25
申请人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis M. Staudt , George Wright , Sandeep Dave , Bruce Tan , John I. Powell , Wyndham Wilson , Elaine Jaffe , Wing C. Chan , Timothy C. Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard I. Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia M Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaløy , Harald Holte , Jan Delabie , T. Andrew Lister
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译： 基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。 此外，基因表达数据可用于开发更准确的生存预测因子。 本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。 本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。 本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。 该信息将有助于开发与特定受试者一起使用的治疗方法。
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8.发明申请公开(公告)号：US20070105136A1
公开(公告)日：2007-05-10
申请号：US11493387
申请日：2006-07-25
申请人： Louis Staudt , George Wright , Sandeep Dave , Bruce Tan , John Powell , Wyndham Wilson , Elaine Jaffe , Wing Chan , Timothy Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
发明人： Louis Staudt , George Wright , Sandeep Dave , Bruce Tan , John Powell , Wyndham Wilson , Elaine Jaffe , Wing Chan , Timothy Greiner , Dennis Weisenburger , James Armitage , Kai Fu , Richard Fisher , Lisa Rimsza , Thomas Miller , Thomas Grogan , Elias Campo , Silvia Bea , Itziar Salaverria , Armando Lopez-Guillermo , Emili Montserrat , Victor Moreno , Andreas Zettl , German Ott , Hans-Konrad Muller-Hermelink , Andreas Rosenwald , Julie Vose , Randy Gascoyne , Joseph Connors , Erlend Smeland , Stein Kvaloy , Harald Holte , Jan Delabie , T. Andrew Lister
CPC分类号： G01N33/6842 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N2333/51 , G06F19/20 , G06F19/24 , Y02A90/26
摘要： Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.
摘要翻译： 基因表达数据为更准确地鉴定和诊断淋巴组织增生性疾病提供了基础。 此外，基因表达数据可用于开发更准确的生存预测因子。 本发明公开了基于基因表达模式鉴定，诊断和预测淋巴瘤或淋巴组织增生性疾病存活的方法。 本发明公开了一种用于从淋巴瘤样品获得基因表达数据的新型微阵列Lymph Dx微阵列。 本发明还公开了多种利用淋巴瘤基因表达数据来确定特定淋巴瘤的身份并预测患有特定淋巴瘤的受试者的存活的方法。 该信息将有助于开发与特定受试者一起使用的治疗方法。
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9.发明申请Elisa assay of serum soluble cd22 to assess tumor burnden/relapse in subjects with leukemia and lymphoma 审中-公开Elisa测定血清可溶性cd22以评估白血病和淋巴瘤受试者的肿瘤烧伤/复发公开(公告)号：US20050244828A1
公开(公告)日：2005-11-03
申请号：US10514910
申请日：2003-05-20
IPC分类号： A61B20060101 , A61K39/395 , C07K16/00 , C07K16/28 , C12Q1/68 , G01N33/50 , G01N33/53 , G01N33/574
CPC分类号： C07K16/2803 , A61K2039/505 , G01N33/5052 , G01N33/57426 , G01N2333/70596
摘要： Disclosed herein are methods of using previously unknown soluble forms of CD22 (sCD22) present in the serum of subjects with B-cell leukemias and lymphomas to assess tumor burden in the subjects. Also disclosed are methods of diagnosing or prognosing development or progression of a B-cell lymphoma or leukemia in a subject, including detecting sCD22 in a body fluid sample taken or derived from the subject, for instance serum.
摘要翻译： 本文公开了使用存在于患有B细胞白血病和淋巴瘤的受试者血清中的先前未知的可溶形式的CD22（sCD22）的方法来评估受试者的肿瘤负担。 还公开了诊断或预测受试者中B细胞淋巴瘤或白血病的发展或进展的方法，包括检测取自或衍生自受试者的体液样品中的sCD22，例如血清。
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公开(公告)号：USRE40839E1
公开(公告)日：2009-07-07
申请号：US09035702
申请日：1998-03-05
IPC分类号： A61K31/335
CPC分类号： A61K31/335
摘要： The present invention is a method of treatment for a patient with cancer. In particular, it is a method of treating patients having lymphomas and breast cancer using the microtubule agent, Taxol. The present method of administration, serves to prevent or retard the adverse side effects associated with Taxol and reduces the chances of a patient developing mdr Taxol resistance. The novel method of treatment provides a low-dose, long-term exposure to Taxol in a patient.
摘要翻译： 本发明是一种治疗癌症患者的方法。 特别地，它是一种治疗患者的方法，其具有<？delete-start id =“DEL-S-00001”date =“20090707”→>淋巴瘤，<？delete-end id =“DEL-S-00001” 乳腺癌使用微管剂，紫杉醇。 目前的施用方法用于预防或延缓与紫杉醇相关的不利副作用，并降低患者发展mdr紫杉醇耐药性的机会。 新型治疗方法在患者中提供低剂量，长期暴露于紫杉醇。
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