公开(公告)号：US20100093628A1

公开(公告)日：2010-04-15

申请号：US12537888

申请日：2009-08-07

申请人： Luc DESNOYER ,  Ellen H. FILVAROFF ,  Diane PENNICA

发明人： Luc DESNOYER ,  Ellen H. FILVAROFF ,  Diane PENNICA

IPC分类号： A61K38/17 ,  C12N5/00 ,  A61P19/00

CPC分类号： C07K14/475 ,  A61K38/00 ,  C07K14/47

摘要： The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.

摘要翻译： 本发明涉及软骨的治疗和修复方法，包括损伤的软骨或包括关节炎在内的退行性软骨疾病，包括施用WISP多肽。 任选地，给药可以与一种或多种软骨剂（例如肽生长因子，分解代谢拮抗剂，骨，滑膜，抗炎因子）组合。 或者，该方法提供了由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括与标准手术技术组合施用WISP多肽。 或者，该方法提供对由损伤或退行性软骨障碍损伤的软骨的治疗和修复，包括施用有效量的WISP多肽以前治疗的软骨细胞。