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    Apparatus for treating atrial tachyarrhythmias with synchronized shocks
    1.
    发明授权
    Apparatus for treating atrial tachyarrhythmias with synchronized shocks 失效
    用同步冲击治疗房性快速性心律失常的装置

    公开(公告)号：US6091988A

    公开(公告)日：2000-07-18

    申请号：US70690

    申请日：1998-04-30

    申请人： Eduardo N. Warman ,  Michael R. S. Hill ,  David K. L. Peterson ,  Rahul Mehra ,  Luc R. Mongeon

    发明人： Eduardo N. Warman ,  Michael R. S. Hill ,  David K. L. Peterson ,  Rahul Mehra ,  Luc R. Mongeon

    IPC分类号： A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/3956 ,  A61N1/3622 ,  A61N1/3987

    摘要： An implantable anti-tachyarrhythmia device which delivers atrial cardioversion or defibrillation pulses heart in response to detection of atrial tachyarrhythmias. The pulses are synchronized to atrial and ventricular events in such a fashion as to assure they occur outside of the vulnerable periods associated with both chambers. The device is provided with a pulse synchronizer which defines a first synchronization interval initiated following a sensed atrial event and a second synchronization interval initiated responsive to a sensed ventricular event and a pulse triggerer which triggers delivery of a cardioversion or defibrillation pulse responsive to the first and second synchronization intervals simultaneously being underway. In particular, the pulse triggerer may be responsive to initiation of the first synchronization interval during the second synchronization interval. In addition, the synchronizer may also define minimum time intervals following ventricular events and the triggerer may additionally be responsive to expiration of a defined minimum time interval following a ventricular event preceding the sensed ventricular event which initiated the second synchronization interval currently underway.

    摘要翻译： 一种可植入的抗快速性心律失常装置，其响应于心房快速性心律失常的检测而传送心房心脏复律或除颤脉冲心脏。 这些脉冲以这样的方式与心房和心室事件同步，以确保它们发生在与两个腔室相关联的脆弱周期之外。 该装置设置有脉冲同步器，该脉冲同步器限定在感测的心房事件之后启动的第一同步间隔和响应于感测到的心室事件而发起的第二同步间隔和脉冲触发器，其响应于第一和第二同步间隔触发心脏复律或除颤脉冲的传递 第二同步间隔同时进行。 特别地，脉冲触发器可以响应于在第二同步间隔期间启动第一同步间隔。 此外，同步器还可以定义心室事件之后的最小时间间隔，并且触发器可以另外响应于起始于当前正在进行的第二同步区间的感测的心室事件之前的心室事件之后的限定的最小时间间隔的到期。

    Cardioversion energy reduction system
    2.
    发明授权
    Cardioversion energy reduction system 失效
    心律转换能量减少系统

    公开(公告)号：US5836976A

    公开(公告)日：1998-11-17

    申请号：US846747

    申请日：1997-04-30

    申请人： Xiaoyi Min ,  Li Wang ,  Rahul Mehra ,  Paul J. DeGroot ,  Walter H. Olson ,  Luc R. Mongeon ,  Michael R. S. Hill

    发明人： Xiaoyi Min ,  Li Wang ,  Rahul Mehra ,  Paul J. DeGroot ,  Walter H. Olson ,  Luc R. Mongeon ,  Michael R. S. Hill

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3956 ,  A61N1/3925 ,  A61N1/3987

    摘要： In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.

    摘要翻译： 在植入式心脏起搏器/心律转复除颤器中，用于将心脏复律治疗的输送与患者呼吸周期的最佳点或阶段相关联的系统，以在心脏复律电极之间的阻抗最小化时实现治疗的传递。 在与基本上与心脏腔室接触的心脏复律电极一起使用的第一个应用中，最佳点或阶段在吸气结束时。 在与远离心脏室的位置的至少一个心脏复律电极一起使用的第二个应用中，最佳点或阶段是结束期满或开始吸气。 复发疗法与心室感觉事件（如果存在）同步传递。 如果在治疗时间内不能确定呼吸周期的最佳点或相位，则可以传送预休克以通过振膜的刺激收缩引起呼吸循环。

    Defibrillation threshold reduction system
    3.
    发明授权
    Defibrillation threshold reduction system 失效
    除颤门限降低系统

    公开(公告)号：US5713924A

    公开(公告)日：1998-02-03

    申请号：US495251

    申请日：1995-06-27

    申请人： Xiaoyi Min ,  Luc R. Mongeon ,  Michael R. S. Hill

    发明人： Xiaoyi Min ,  Luc R. Mongeon ,  Michael R. S. Hill

    IPC分类号： A61N1/39

    CPC分类号： A61N1/3962 ,  A61N1/395

    摘要： A method an apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a high frequency, low energy pulse burst is delivered via pacing electrodes, accompanied by a high energy pulse delivered via defibrillation electrodes. The low energy pulse burst is preferably delivered to an area of the heart which exhibits relatively lower current density during delivery of the high energy pulse.

    摘要翻译： 一种用于治疗纤维性颤动，特别是心房颤动的装置的方法。 响应于原纤维的检测，通过起搏电极输送高频，低能脉冲脉冲，伴随着通过除颤电极传送的高能量脉冲。 低能量脉冲脉冲优选地被传送到在高能量脉冲传送期间呈现相对较低的电流密度的心脏区域。

    Method and apparatus for treatment of atrial fibrillation
    4.
    发明授权
    Method and apparatus for treatment of atrial fibrillation 失效
    用于治疗房颤的方法和装置

    公开(公告)号：US5620468A

    公开(公告)日：1997-04-15

    申请号：US627959

    申请日：1996-04-02

    申请人： Luc R. Mongeon ,  Michael R. S. Hill ,  Rahul Mehra

    发明人： Luc R. Mongeon ,  Michael R. S. Hill ,  Rahul Mehra

    IPC分类号： A61N1/38 ,  A61N1/39

    CPC分类号： A61N1/385 ,  A61N1/3962 ,  A61N1/395

    摘要： A method and apparatus for treating fibrillation, particularly atrial fibrillation. In response to detection of fibrillation, a series of low energy pulse bursts is delivered, separated by defined inter-burst intervals, and including bursts unsynchronized to heart depolarizations. Detection of termination of fibrillation during inter-burst intervals results in cancellation of further pulse bursts to prevent reinduction of fibrillation.

    摘要翻译： 一种用于治疗原纤维性颤动的方法和装置，特别是心房颤动。 响应于原纤维化的检测，一系列低能量脉冲串被传送，通过限定的突发间隔隔开，并且包括与心脏去极化不同步的突发。 在突发间隔期间检测到颤动的终止导致进一步的脉冲脉冲的消除，以防止纤维性颤动的再诱导。

    Method and apparatus for prevention of atrial tachyarrhythmias
    6.
    发明授权
    Method and apparatus for prevention of atrial tachyarrhythmias 有权
    用于预防房性快速性心律失常的方法和装置

    公开(公告)号：US06185459B2

    公开(公告)日：2001-02-06

    申请号：US09373699

    申请日：1999-08-13

    申请人： Rahul Mehra ,  Michael R. S. Hill ,  Stephanie M. Fitts ,  Luc R. Mongeon

    发明人： Rahul Mehra ,  Michael R. S. Hill ,  Stephanie M. Fitts ,  Luc R. Mongeon

    IPC分类号： A61N1362

    CPC分类号： A61N1/3686 ,  A61N1/3622 ,  A61N1/3688 ,  A61N1/3706

    摘要： A cardiac pacemaker and a method of its use. The pacemaker paces a patient's heart in a tachyarrhythmia prevention pacing mode for an extended time period, defines a metric of success of the tachyarrhythmia prevention pacing mode, monitors the metric over the extended time period and, responsive to the monitored metric, adjusts the tachyarrhythmia prevention pacing mode. Adjustment of the tachyarrhythmia prevention pacing mode may take the form of pacing the patient's heart with a different set of electrodes, pacing the patient's heart with a different tachyarrhythmia prevention pacing mode and/or terminating operation of the tachyarrhythmia prevention pacing mode.

    摘要翻译： 心脏起搏器及其使用方法。 心脏起搏器在长时间的快速性心律失常预防起搏模式下对患者的心脏起搏，定义了快速心律失常预防起搏模式成功的指标，在​​延长的时间段内监测指标，并根据监测的指标调整心律失常预防 起搏模式 快速心律失常预防起搏模式的调整可以采取以不同的电极组起搏患者心脏的形式，使患者的心脏具有不同的快速性心律失常预防起搏模式和/或终止快速性心律失常预防起搏模式的操作。

    Cardioversion energy reduction system
    8.
    发明授权
    Cardioversion energy reduction system 失效
    心律转换能量减少系统

    公开(公告)号：US5954752A

    公开(公告)日：1999-09-21

    申请号：US846938

    申请日：1997-04-30

    申请人： Luc R. Mongeon ,  Michael R. S. Hill

    发明人： Luc R. Mongeon ,  Michael R. S. Hill

    IPC分类号： A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/3962 ,  A61N1/3622 ,  A61N1/3987

    摘要： In an implantable pacemaker.backslash.cardioverter.backslash.defibrillator, a system for correlating the delivery of an atrial cardioversion therapy to an optimum blood pressure to effect delivery of the therapy when the volume of the atrium is minimized. In a first embodiment, the blood pressure in the atrium or ventricle is monitored and delivery is timed to a low blood pressure occurring as blood is emptying from the atrium. In a variation ventricular pacing may be provided to ensure that the ventricles are contracting forcefully and at a rate which optimizes atrial emptying. In a second embodiment, the delivery of the cardioversion therapy is also timed to an optimum point or phase of the respiratory cycle. The optimum point or phase of the respiration cycle depends in part on the chamber to be cardioverted and the location of the cardioversion electrodes with respect to the chamber.

    摘要翻译： 在植入式心脏起搏器+ 544心律转复+ 544除颤器中，一种用于将心房复律治疗的输送与最佳血压相关联的系统，以在心房体积最小化时实现治疗递送。 在第一实施例中，监测心房或心室中的血压，并且当血液从心房排空时，输送定时到低血压。 在一个变化中可以提供心室起搏，以确保心室有力地收缩，并以优化心房排空的速度。 在第二实施例中，复律疗法的传递也定时到呼吸周期的最佳点或阶段。 呼吸循环的最佳点或相位部分地取决于要被转复的腔室和心脏复律电极相对于腔室的位置。

    AUTOMATIC PERSONALIZATION OF PARAMETER SETTINGS AND ALGORITHMS IN A MEDICAL DEVICE
    9.
    发明申请
    AUTOMATIC PERSONALIZATION OF PARAMETER SETTINGS AND ALGORITHMS IN A MEDICAL DEVICE 审中-公开
    医疗设备中参数设置和算法的自动个性化

    公开(公告)号：US20120109238A1

    公开(公告)日：2012-05-03

    申请号：US12915863

    申请日：2010-10-29

    申请人： Amisha S. Patel ,  Luc R. Mongeon ,  Kenneth M. Riff

    发明人： Amisha S. Patel ,  Luc R. Mongeon ,  Kenneth M. Riff

    IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/37252 ,  A61N1/37288 ,  G16H40/63

    摘要： A system includes a data retrieval module and a determination module. The data retrieval module receives a command from a user, the command indicating a first implantable medical device (IMD) and a second IMD. The data retrieval module also retrieves a first set of data from the first IMD in response to the command and retrieves a second set of data from a datastore. The second set of data includes data retrieved from the first IMD and stored in the datastore prior to receiving the command. The determination module determines a third set of data based on the first and second sets of data and transfers the third set of data to the second IMD.

    摘要翻译： 系统包括数据检索模块和确定模块。 数据检索模块从用户接收命令，指示第一可植入医疗装置（IMD）和第二IMD。 数据检索模块还响应于命令从第一IMD检索第一组数据，并从数据存储区检索第二组数据。 第二组数据包括在接收命令之前从第一IMD检索并存储在数据存储中的数据。 确定模块基于第一和第二组数据确定第三组数据，并将第三组数据传送到第二IMD。

    Algorithm for the automatic determination of optimal AV an VV intervals
    10.
    发明授权
    Algorithm for the automatic determination of optimal AV an VV intervals 有权
    用于自动确定最佳AV的VV间隔的算法

    公开(公告)号：US07228174B2

    公开(公告)日：2007-06-05

    申请号：US10135912

    申请日：2002-04-29

    申请人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

    发明人： John E. Burnes ,  Yong K. Cho ,  David Igel ,  Luc R. Mongeon ,  John C. Rueter ,  Harry Stone ,  Jodi Zilinski

    IPC分类号： A61N1/362

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

    摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.

    摘要翻译： 用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。 在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。 为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。 另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。 另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。 另一实施例改变VV间隔以最大化阻抗变化。