公开(公告)号：US07531553B2

公开(公告)日：2009-05-12

申请号：US10804915

申请日：2004-03-19

申请人： Lucian V. Di Pietro ,  Jean-Christophe Harmange ,  Benny C. Askew, Jr. ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Joseph L. Kim ,  Vinod F. Patel ,  Michele Potashman ,  Simon van der Plas

发明人： Lucian V. Di Pietro ,  Jean-Christophe Harmange ,  Benny C. Askew, Jr. ,  Daniel Elbaum ,  Julie Germain ,  Gregory J. Habgood ,  Joseph L. Kim ,  Vinod F. Patel ,  Michele Potashman ,  Simon van der Plas

IPC分类号： A61K31/47 ,  C07D215/00

CPC分类号： C07D401/12 ,  C07D235/30 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

摘要翻译： 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

公开(公告)号：US07101868B2

公开(公告)日：2006-09-05

申请号：US10823809

申请日：2004-04-12

申请人： Daniel Elbaum ,  Benny C. Askew, Jr. ,  Shon Booker ,  Julie Germain ,  Gregory J. Habgood ,  Michael Handley ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Vinod F. Patel ,  Chester Chenguang Yuan ,  Joseph L. Kim ,  Guolin Cai ,  Guoqing Chen ,  Michael Croghan ,  Lucian V. Di Pietro ,  Celia Dominguez ,  Qi Huang ,  Leon M. Smith, II ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu

发明人： Daniel Elbaum ,  Benny C. Askew, Jr. ,  Shon Booker ,  Julie Germain ,  Gregory J. Habgood ,  Michael Handley ,  Tae-Seong Kim ,  Aiwen Li ,  Nobuko Nishimura ,  Vinod F. Patel ,  Chester Chenguang Yuan ,  Joseph L. Kim ,  Guolin Cai ,  Guoqing Chen ,  Michael Croghan ,  Lucian V. Di Pietro ,  Celia Dominguez ,  Qi Huang ,  Leon M. Smith, II ,  Andrew Tasker ,  Ning Xi ,  Shimin Xu

IPC分类号： A61K31/33 ,  A61K31/44 ,  C07D211/62 ,  C07D213/72

CPC分类号： C07D213/81 ,  C04B35/632 ,  C07D213/82 ,  C07D237/04 ,  C07D237/24 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04

摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.