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33 条记录 (耗时 0.024 秒)

    Novel aminobenzocycloheptenes
    3.
    发明授权
    Novel aminobenzocycloheptenes 失效
    新型氨基苯并环庚烯

    公开(公告)号：US4154852A

    公开(公告)日：1979-05-15

    申请号：US835171

    申请日：1977-09-20

    申请人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont

    发明人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont

    IPC分类号： A61K31/13 ,  A61K31/04 ,  A61K31/135 ,  A61P25/24 ,  A61P25/26 ,  C07C57/145 ,  C07C57/15 ,  C07C67/00 ,  C07C209/00 ,  C07C209/36 ,  C07C209/60 ,  C07C211/42 ,  C07C211/57 ,  C07C213/00 ,  C07C217/74 ,  C07C225/00 ,  A01N9/20 ,  C07C87/64 ,  C07C91/28 ,  C07C93/14

    CPC分类号： C07C57/15 ,  C07C57/145

    摘要： Novel 7-aminobenzocycloheptenes of the formula ##STR1## wherein X is selected from the group consisting of --NO.sub.2, --NH.sub.2, CH.sub.3 O-- and --OH, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.2 is alkyl of 1 to 5 carbon atoms and R.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a saturated heterocycle of 4 to 6 ring carbon atoms optionally containing a second heteroatom in the ring and optionally substituted with an alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts in optically active or racemic mixture form having antidepressant activity and a process for their preparation.

    摘要翻译： 新颖的式I的7-氨基苯并环庚烯，其中X选自-NO 2，-NH 2，CH 3 O-和-OH，R 1选自氢和1至5个碳原子的烷基， R 2是1至5个碳原子的烷基，R 1和R 2与它们所连接的氮原子一起形成4至6个环碳原子的饱和杂环，任选地在该环中含有第二个杂原子且任选地被1个 至5个碳原子及其无毒的药学上可接受的酸加成盐，其具有抗抑郁活性的旋光或外消旋混合物形式及其制备方法。

    Cycloheptindoles, compositions and use
    5.
    发明授权
    Cycloheptindoles, compositions and use 失效
    Cycloheptindoles，组成和用途

    公开(公告)号：US4313944A

    公开(公告)日：1982-02-02

    申请号：US237062

    申请日：1981-02-23

    申请人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont

    发明人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont

    IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/535 ,  A61P1/04 ,  A61P9/12 ,  A61P25/00 ,  C07D209/94 ,  C07D498/06 ,  C07D498/04

    CPC分类号： C07D209/94

    摘要： Novel compounds selected from the group consisting of optically active isomers and racemic mixtures of cycloheptindoles of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms, R.sub.1 is selected from the group consisting of hydrogen, chlorine and bromine and R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, alkenyl and alkynyl of 3 to 7 carbon atoms and optionally substituted aralkyl of 7 to 12 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having dopaminergic agonist and antianoxic properties and a process for their preparation and novel intermediates.

    摘要翻译： 新型化合物，其选自光学活性异构体和式Ⅺ的环庚啶的外消旋混合物，其中R选自氢，1至5个碳原子的烷基和7至12个碳的任选取代的芳烷基 原子，R 1选自氢，氯和溴，R 2选自氢，1至5个碳原子的烷基，4至7个碳原子的环烷基烷基，3至7个碳的链烯基和炔基 原子和任选取代的7-12个碳原子的芳烷基及其无毒的药学上可接受的具有多巴胺能激动剂和抗氧化性质的酸加成盐及其制备方法和新型中间体。

    3-Aryloxy-3-aryl-propaneamines and their method of use
    6.
    发明授权
    3-Aryloxy-3-aryl-propaneamines and their method of use 失效
    3-芳氧基-3-芳基 - 丙胺及其使用方法

    公开(公告)号：US4296126A

    公开(公告)日：1981-10-20

    申请号：US13831

    申请日：1979-02-22

    申请人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont

    发明人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont

    IPC分类号： A61K31/135 ,  A61K31/16 ,  A61K31/165 ,  A61P3/04 ,  C07C67/00 ,  C07C213/00 ,  C07C217/48 ,  C07C233/16 ,  C07C233/25 ,  A01N37/30 ,  C07C93/02

    CPC分类号： A61K31/135 ,  C07C233/16

    摘要： Novel benzene-propanamines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen, chlorine, fluorine and bromine, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.2 is alkyl of 1 to 5 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, chlorine, bromine, --CF.sub.3, methyl and methoxy when R.sub.4 is nitro and R.sub.3 is selected from the group consisting of amino and acetamido when R.sub.4 is hydrogen and their non-toxic, pharmaceutically acceptable acid addition salts having anorexigenic activity and inhibit serotonine uptake in vivo and in vitro and their preparation.

    摘要翻译： 具有式“IMAGE”I'的新型苯丙胺，其中X选自氢，氯，氟和溴，R 1选自氢和1至5个碳原子的烷基，R 2是烷基 当R 4为硝基时，R 3选自氢，氯，溴，-CF 3，甲基和甲氧基，当R 4为氢时，R 3选自氨基和乙酰氨基， 具有厌食活性的药学上可接受的酸加成盐，并且在体内和体外抑制血清素摄取及其制备。

    Novel benzazepines
    10.
    发明授权
    Novel benzazepines 失效
    新型苯并氮杂

    公开(公告)号：US4100278A

    公开(公告)日：1978-07-11

    申请号：US782747

    申请日：1977-03-30

    申请人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont ,  Marie-Helene Kannengiesser

    发明人： Lucien Nedelec ,  Daniel Frechet ,  Claude Dumont ,  Marie-Helene Kannengiesser

    IPC分类号： A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D223/16

    CPC分类号： C07D223/16

    摘要： Novel benzazepines of the formula ##STR1## wherein n is 0 or 1 and R and R.sub.1 are individually selected from the group consisting of hydrogen and methyl with the proviso that when R.sub.1 is methyl, R is also methyl and their non-toxic, pharmaceutically acceptable acid addition salts having antidepressive activity and novel intermediates and processes for the preparation of the said compounds.

    摘要翻译： 式其中n为0或1的新的苯并氮杂，R和R 1分别选自氢和甲基，条件是当R 1是甲基时，R也是甲基，它们是无毒的，药学上 具有抗抑郁活性的可接受的酸加成盐和用于制备所述化合物的新中间体和方法。