公开(公告)号：US4497820A

公开(公告)日：1985-02-05

申请号：US491386

申请日：1983-05-04

申请人： Lucio Merlini ,  Alessandro Rossi ,  Metilde Buonamici

发明人： Lucio Merlini ,  Alessandro Rossi ,  Metilde Buonamici

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61K31/38 ,  A61K31/382 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D311/68 ,  C07D311/72 ,  C07D311/96 ,  C07D335/04 ,  C07D335/06

CPC分类号： C07D335/06 ,  C07D311/68 ,  C07D311/96 ,  C07D335/04

摘要： Substituted imino derivatives of 4 H-2, 3-dihydrobenzopyran and 4 H-2, 3-dihydrobenzothiopyran, and pharmaceutical compositions containing them. The compounds are active on the central nervous system, in particular as central nervous system depressants, i.e., sedatives, anticonvulsive agents, tranquilizers and sleep-inducing agents.

摘要翻译： 4 H-2,3-二氢苯并吡喃和4 H-2,3,3-二氢苯并噻喃的取代亚氨基衍生物和含有它们的药物组合物。 该化合物在中枢神经系统上是有活性的，特别是作为中枢神经系统抑制剂，即镇静剂，抗惊厥药，镇静剂和睡眠诱导剂。

公开(公告)号：US5202325A

公开(公告)日：1993-04-13

申请号：US499413

申请日：1990-07-12

申请人： Alessandro Rossi ,  Metilde Buonamici ,  Lorenzo Pegrassi ,  Enzo Brambilla

发明人： Alessandro Rossi ,  Metilde Buonamici ,  Lorenzo Pegrassi ,  Enzo Brambilla

IPC分类号： C07D457/02 ,  A61K31/48 ,  A61K31/495 ,  A61P1/08

CPC分类号： A61K31/495 ,  A61K31/48 ,  Y10S514/872

摘要： Compounds of the formula I ##STR1## wherein n is 1 or 2, R.sub.1 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sub.2 represents a hydrogen atom and R.sub.3 represents a hydrogen atom or a hydroxy group or R.sub.2 and R.sub.3 together represent a chemical bond, R.sub.4 represents a hydrogen atom, or a phenyl or C.sub.1 -C.sub.4 alkyl group, R.sub.5 represents a C.sub.1 -C.sub.4 alkyl group or an alkyl group and R.sub.6 represents a hydrogen or halogen atom, and the pharmaceutically acceptable salt thereof, are useful for the manufacture of a pharmaceutical composition useful in the treatment of emesis.

公开(公告)号：US4847253A

公开(公告)日：1989-07-11

申请号：US273021

申请日：1988-11-18

申请人： Metilde Buonamici ,  Lorenzo Pegrassi ,  Alessandro Rossi ,  Sergio Mantegani

发明人： Metilde Buonamici ,  Lorenzo Pegrassi ,  Alessandro Rossi ,  Sergio Mantegani

IPC分类号： C07D457/02 ,  A61K31/48 ,  A61K31/495 ,  A61P25/00 ,  A61P43/00

CPC分类号： A61K31/48

摘要： Compounds of the formula I ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either R.sub.2 and R.sub.3 represent hydrogen atoms or together represent a chemical bond, R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sub.5 represents a C.sub.1 -C.sub.4 alkyl group or an allyl group and R.sub.6 represents a hydrogen or halogen atom, and pharmaceutically acceptable salts thereof, are disclosed as being useful for the treatment of extrapyramidal syndromes such as Parkinson's disease.