专利检索 ap:("Luigi Barbieri" OR "Pierre Casellas" OR "Fiorenzo Stirpe") AND inv:"Luigi Barbieri" 第 1 页

1.

发明授权
Modified trichokirin and their preparation for use in conjugates as inhibitors of protein synthesis 失效
标题翻译：改性毛滴虫素及其作为蛋白质合成抑制剂的缀合物的制备

公开(公告)号：US5162502A

公开(公告)日：1992-11-10

申请号：US714870

申请日：1991-06-13

申请人： Luigi Barbieri , Pierre Casellas , Fiorenzo Stirpe

发明人： Luigi Barbieri , Pierre Casellas , Fiorenzo Stirpe

IPC分类号： A61K36/428 , A61K38/00 , C07K14/415

CPC分类号： C07K14/415 , A61K36/428 , A61K38/00

摘要： The present invention relates to a novel glycoprotein, extracted from the seeds of Trichosanthes kirilowii, called: trichokirin, as well as to its modified derivatives containing a free or blocked SH group. It relates to a process for its preparation, to its use and to pharmaceutical compositions in which it is present.

摘要翻译： 本发明涉及从Trichosanthes kirilowii的种子提取的称为trichokirin的新型糖蛋白，以及其含有游离或封闭的SH基团的修饰衍生物。它涉及其制备方法及其用途及其存在的药物组合物。

2.

发明授权
Immunotoxins, process for their preparation and pharmaceutical compositions in which they are present 失效
标题翻译：免疫毒素，其制备方法及其存在的药物组合物

公开(公告)号：US4981953A

公开(公告)日：1991-01-01

申请号：US073263

申请日：1987-07-14

申请人： Luigi Barbieri , Pierre Casellas , Fiorenzo Stirpe

发明人： Luigi Barbieri , Pierre Casellas , Fiorenzo Stirpe

IPC分类号： A61K39/395 , A61K39/00 , A61K47/48 , A61P35/00 , C07K1/113 , C07K14/00 , C07K14/415 , C07K16/00 , C07K19/00

CPC分类号： A61K47/48461 , A61K47/48715 , Y10S514/885

摘要： The present invention relates to the immunotoxines which are obtained by the covalent coupling of, on the one hand, trichosanthin or trichokirin, as such or appropriately modified with, on the other hand, an antibody or antibody fragment, used in its natural form or correctly modified, which is capable of selectively recognizing an antigen carried by the target cells to be destroyed.

摘要翻译： 本发明涉及免疫毒素，其通过共同偶联，一方面是天竺葵素或trichokirin，或另一方面与其自然形式或正确地使用的抗体或抗体片段其能够选择性地识别待破坏的靶细胞携带的抗原。

3.

发明授权
Inhibitor of protein synthesis, process for its isolation, its use and pharmaceutical compositions in which it is present 失效
标题翻译：蛋白质合成抑制剂，其分离方法及其用途及其存在的药物组合物

公开(公告)号：US5037960A

公开(公告)日：1991-08-06

申请号：US73264

申请日：1987-07-14

申请人： Luigi Barbieri , Pierre Casellas , Fiorenzo Stirpe

发明人： Luigi Barbieri , Pierre Casellas , Fiorenzo Stirpe

IPC分类号： A61K39/395 , A61K36/00 , A61K36/428 , A61K38/00 , A61P35/00 , C07K1/113 , C07K1/14 , C07K14/00 , C07K14/415

CPC分类号： C07K14/415 , A61K36/428 , A61K38/00

摘要： The present invention relates to a novel glycoprotein, extracted from the seeds of Trichosanthes kirilowii, called: trichokirin, as well as to its modified derivatives containing a free or blocked SH group.It relates to a process for its preparation, to its use and to pharmaceutical compositions in which it is present.

摘要翻译： 本发明涉及从Trichosanthes kirilowii的种子提取的称为trichokirin的新型糖蛋白，以及其含有游离或封闭的SH基团的修饰衍生物。它涉及其制备方法及其用途及其存在的药物组合物。