公开(公告)号：US20050240013A1

公开(公告)日：2005-10-27

申请号：US10518980

申请日：2003-06-18

申请人： Luigi De Ambrosi ,  Nicola Iannaccone ,  Sergio Gonella ,  Elena Vismara ,  Solitario Nesti ,  Giangiaocomo Torri

发明人： Luigi De Ambrosi ,  Nicola Iannaccone ,  Sergio Gonella ,  Elena Vismara ,  Solitario Nesti ,  Giangiaocomo Torri

IPC分类号： C08B37/00 ,  C07B31/00 ,  C08B37/10

CPC分类号： C08B37/0063 ,  C08B37/0075 ,  C08B37/0078

摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by Gel Permeation for obtaining the desired Molecular Weight.

摘要翻译： 本发明涉及通过使用电子束辐射特征的糖胺聚糖解聚方法，任选地在选自醚，醇，醛，酰胺和甲酸的有机化合物存在下进行。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中，并通过凝胶渗透分级，以获得所需的分子量。

公开(公告)号：US07321034B2

公开(公告)日：2008-01-22

申请号：US10518980

申请日：2003-06-18

申请人： Luigi De Ambrosi ,  Nicola Iannaccone ,  Sergio Gonella ,  Elena Vismara ,  Solitario Nesti ,  Giangiaocomo Torri

发明人： Luigi De Ambrosi ,  Nicola Iannaccone ,  Sergio Gonella ,  Elena Vismara ,  Solitario Nesti ,  Giangiaocomo Torri

IPC分类号： C08B37/10

CPC分类号： C08B37/0063 ,  C08B37/0075 ,  C08B37/0078

摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of electron beam radiation, optionally in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to the intermediate depolymerized heparin obtained by the process. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

摘要翻译： 本发明涉及通过使用电子束辐射特征的糖胺聚糖解聚方法，任选地在选自醚，醇，醛，酰胺和甲酸的有机化合物存在下进行。 本发明还涉及通过该方法得到的中间解聚肝素。 中间解聚的肝素可以溶解在缓冲溶液中并通过凝胶渗透分馏以获得所需的分子量。