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18 条记录 (耗时 0.013 秒)

    PROCESS FOR THE PURIFICATION OF HEPARAN SULFATE AND USE THEREOF IN COSMETOLOGICAL AND DERMATOLOGICAL PREPARATIONS
    1.
    发明申请
    PROCESS FOR THE PURIFICATION OF HEPARAN SULFATE AND USE THEREOF IN COSMETOLOGICAL AND DERMATOLOGICAL PREPARATIONS 有权
    硫代硫酸盐的净化方法及其在化学和制药领域的应用

    公开(公告)号：US20110288047A1

    公开(公告)日：2011-11-24

    申请号：US13129030

    申请日：2009-09-29

    申请人： Luigi De Ambrosi

    发明人： Luigi De Ambrosi

    IPC分类号： A61K31/727 ,  C08B37/10 ,  A61Q19/02 ,  A61Q19/08 ,  A61P29/00

    CPC分类号： A61K8/73 ,  A61K31/726 ,  A61K31/727 ,  A61K2800/522 ,  A61K2800/75 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/02 ,  A61Q19/08

    摘要： The present invention relates to cosmetological and dermatological compositions comprising heparan sulfate. The invention further discloses a process for the purification of heparan sulfate for dermatological and cosmetological applications, which process comprises the following steps: solubilization of heparan sulfate in water, adsorption on an anion exchange resin, desorption from the resin by using conditions which result in selective desorption of hepar an sulfate. The cosmetological and dermatological compositions according to the invention show, inter alia, anti-age, lenitive, and whitening effect.

    摘要翻译： 本发明涉及包含硫酸乙酰肝素的美容和皮肤病学组合物。 本发明还公开了一种用于皮肤病学和美容应用的硫酸乙酰肝素的纯化方法，该方法包括以下步骤：将硫酸乙酰肝素溶解于水中，在阴离子交换树脂上吸附，通过使用导致选择性的条件从树脂中解吸 肝素硫酸盐解吸。 根据本发明的美容和皮肤病学组合物尤其表现出抗衰老，延缓和美白效果。

    Process for preparing epoxy-heparides, the products obtained and pharmaceutical compositions containing them
    3.
    发明授权
    Process for preparing epoxy-heparides, the products obtained and pharmaceutical compositions containing them 失效
    制备环氧 - 肝素的方法，获得的产品和含有它们的药物组合物

    公开(公告)号：US5403827A

    公开(公告)日：1995-04-04

    申请号：US146805

    申请日：1993-11-02

    申请人： Luigi De-Ambrosi

    发明人： Luigi De-Ambrosi

    IPC分类号： C08B37/10 ,  A61K31/715 ,  A61P7/02 ,  A61P9/10 ,  C08B37/00 ,  A61K31/725 ,  C07H3/10 ,  C07H5/06

    CPC分类号： A61K31/715 ,  C08B37/0075

    摘要： There is provided a process for preparing epoxy-heparide polysaccharides of formula (I): ##STR1## wherein A is a pyran ring with substituents 1 and 4 in the axial position and 5 in the equatorial position, and R and R' are hexosamines which constitute a polysaccharide chain bonded to said ring A by a glucoside, and one of R and R' is H when the ring A is in the terminal position of said polysaccharide chains, and said heparide has a COCH.sub.3 to COOH ratio of 0.5, said process comprisinga) N-desulfation of heparin to obtain the corresponding heparamine;b) acetylation of the heparamine of step (a) to obtain the corresponding heparide;c) epoxidation of the heparide of step (b) by treating the heparide with hydrogen peroxide in an alkaline reaction medium at pH 12-14; andd) cooling the solution obtained in step (c) to a temperature of between 15.degree. and 25.degree. C. and adjusting the pH to between 5.8 and 6.0.

    摘要翻译： 提供了制备式（I）的环氧 - 肝素多糖的方法：其中A是在轴向位置具有取代基1和4并且在赤道位置具有5的吡喃环，R和R' 是构成通过葡萄糖苷结合到所述环A上的多糖链的己糖胺，当环A位于所述多糖链的末端时，R和R'之一是H，所述肝素的COCH 3与COOH之比为0.5 所述方法包括a）肝素N-脱硫以获得相应的肝素胺; b）步骤（a）的乙酰胺的乙酰化以获得相应的肝素; c）通过在pH 12-14的碱性反应介质中用过氧化氢处理肝素，对步骤（b）的肝素进行环氧化; 和d）将步骤（c）中获得的溶液冷却至15℃至25℃的温度，并将pH调节至5.8至6.0。

    Extracting protease-inhibitor from animal tissue containing same
    7.
    发明授权
    Extracting protease-inhibitor from animal tissue containing same 失效
    从含有它的动物组织中提取蛋白酶抑制剂

    公开(公告)号：US4216293A

    公开(公告)日：1980-08-05

    申请号：US916536

    申请日：1978-06-19

    申请人： Gianfranco Fedeli ,  Luigi De Ambrosi

    发明人： Gianfranco Fedeli ,  Luigi De Ambrosi

    IPC分类号： C12N9/99 ,  A61K35/12 ,  A61K35/42 ,  A61K38/55 ,  C07K14/81 ,  C08B37/00 ,  C08B37/10 ,  C12N9/48 ,  C07G7/00

    CPC分类号： C08B37/0066 ,  C07K14/8117

    摘要： Protease inhibitor is extracted from fresh or frozen organs of slaughtered animals by an enzymolysis operation which excludes any possibility of interference by azymic autolysis, the enzymolysis being stopped after a time not exceeding 4 hours, whereafter a lysate aqueous solution is obtained by filtration and a quaternary ammonium base is added to the lysate solution to precipitate insolubles, the filtrate being the fraction which contains the expected protease inhibitor.

    摘要翻译： 通过酶解操作从屠宰动物的新鲜或冷冻器官中提取蛋白酶抑制剂，其排除任何可能的干扰自由酶的可能性，在不超过4小时的时间后停止酶解，然后通过过滤获得裂解物水溶液， 将铵碱加入裂解液中以沉淀不溶物，滤液为含有预期蛋白酶抑制剂的级分。

    Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom
    10.
    发明授权
    Process for the physical depolymerization of glycosaminoglycanes and products obtained therefrom 有权
    糖胺聚糖及其制得的产品的物理解聚方法

    公开(公告)号：US07091337B2

    公开(公告)日：2006-08-15

    申请号：US10477293

    申请日：2003-03-11

    申请人： Luigi De Ambrosi ,  Sergio Gonella ,  Elena Vismara

    发明人： Luigi De Ambrosi ,  Sergio Gonella ,  Elena Vismara

    IPC分类号： C08B37/10

    CPC分类号： C08B37/0063 ,  C08B37/0069 ,  C08B37/0072 ,  C08B37/0075 ,  C08B37/0078

    摘要： The invention relates to a process for the depolymerization of glycosaminoglycanes characterized by the use of high-energy radiation in the presence of an organic compound selected from the group consisting of ethers, alcohols, aldehydes, amides and formic acid. The invention also relates to intermediate depolymerized heparin having a molecular weight of between 1,000 and 5,500, absorbance at 400 nm below 0.300 and ratio SO3−/COO−equal to or higher than in the starting heparin. The intermediate depolymerized heparin can be dissolved in a buffer solution and fractionated by gel permeation for obtaining the desired molecular weight.

    摘要翻译： 本发明涉及一种用于解聚糖胺聚糖的方法，其特征在于在选自醚，醇，醛，酰胺和甲酸的有机化合物存在下使用高能辐射。 本发明还涉及分子量为1,000至5,500的中间解聚肝素，400nm处的吸光度低于0.300，SO 3的比例< / SUP>等于或高于起始肝素。 中间解聚的肝素可以溶解在缓冲溶液中并通过凝胶渗透分馏以获得所需的分子量。