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公开(公告)号:US08835614B2
公开(公告)日:2014-09-16
申请号:US13140272
申请日:2009-12-11
申请人: Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
发明人: Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
摘要: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
摘要翻译: 本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。 本文还提供了包含这种缀合物的药物组合物。 本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。
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公开(公告)号:US20110300120A1
公开(公告)日:2011-12-08
申请号:US13140272
申请日:2009-12-11
申请人: Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
发明人: Luis Z. Avila , Clark Q. Pan , Patrick Finn , John Harrahy , Qun Zhou , Yunxiang Zhu , Paul A. Konowicz , Duncan E. Paterson , Andreas Peer , Joseph P. Kutzko , Michael R. Reardon , James E. Stefano , Xiaoyang Zheng , Robert J. Miller , Lauren Young
摘要: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-glycoprotein conjugate.
摘要翻译: 本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。 本文还提供了包含这种缀合物的药物组合物。 本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。
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公开(公告)号:US5827280A
公开(公告)日:1998-10-27
申请号:US618205
申请日:1996-03-19
申请人: Paul Sandock , Lauren Young
发明人: Paul Sandock , Lauren Young
CPC分类号: A61B18/14 , A61B18/148 , A61B18/1482 , A61B2018/00178
摘要: A locking device for a protective sleeve of an endoscopic electrode assembly having a connector for connecting the electrode assembly to a control handle, wherein the locking device comprises a post extending longitudinally from the connector and surrounding the elongated electrode, and a sleeve grip connected to the proximal end of the protective sleeve, surrounding the post. The sleeve grip has an unlocked position wherein the sleeve grip is movable longitudinally with respect to the post and a locked position wherein the sleeve grip is restricted from moving longitudinally with respect to the post.
摘要翻译: 一种用于内窥镜电极组件的保护套的锁定装置,具有用于将电极组件连接到控制手柄的连接器,其中锁定装置包括从连接器纵向延伸并围绕细长电极的柱,以及连接到 保护套的近端,围绕柱。 套筒夹具具有解锁位置,其中套筒夹持件可相对于柱纵向移动,并且锁定位置,其中套筒夹持器相对于柱纵向移动。
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公开(公告)号:US4854115A
公开(公告)日:1989-08-08
申请号:US245969
申请日:1988-09-16
申请人: Dallas W. Jones , Lauren Young
发明人: Dallas W. Jones , Lauren Young
IPC分类号: A01D34/84
CPC分类号: A01D34/84
摘要: An apparatus that can be readily converted from a lawnmower to a trimmer including a housing, an engine mounted thereon, a plurality of wheels rotatably mounted to the housing, a handle secured to the housing and a control linkage system. The housing includes a main body portion and an adjustable segment. The adjustable segment is pivotally connected to the main body of the housing. The adjustable segment is further spring biased in a first position wherein the apparatus is in the traditional lawnmower mode. The control linkage system is operably associated with the adjustable segment so that upon depression of a control lever the adjustable segment pivots upwardly and exposes a portion of the blade. The exposed portion of the blade extends several inches outwardly from the outermost portion of the apparatus. Therefore, the apparatus is able to effectively trim grass from around obstacles such as trees, fences, and posts. An operator need only release the control lever to resume the normal lawnmower cutting operation.
摘要翻译: 一种可以容易地从割草机转换到修剪器的装置,包括壳体,安装在其上的发动机,可旋转地安装到壳体的多个车轮,固定到壳体的手柄和控制连杆系统。 壳体包括主体部分和可调节部分。 可调节段枢转地连接到壳体的主体。 可调节段在第一位置被进一步弹簧偏置,其中该装置处于传统的割草机模式。 控制联动系统可操作地与可调节段相关联,使得当按下控制杆时,可调节段向上枢转并暴露叶片的一部分。 刀片的暴露部分从设备的最外部分向外延伸几英寸。 因此,该装置能够有效地修剪围绕诸如树木,栅栏和柱子之类的障碍物的草。 操作员只需要释放控制杆,恢复正常的割草机切割操作。
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