专利检索 ap:("Lyle J. Arnold, Jr." OR "Mark A. Reynolds" OR "Cristina Giachetti" OR "Alexandre V. Lebedev") AND inv:"Alexandre V. Lebedev" 第 1 页

1.

发明授权
Chimeric oligonucleoside compounds 失效
标题翻译：嵌合寡核苷酸化合物

公开(公告)号：US6060456A

公开(公告)日：2000-05-09

申请号：US960111

申请日：1997-10-27

申请人： Lyle J. Arnold, Jr. , Mark A. Reynolds , Cristina Giachetti , Alexandre V. Lebedev

发明人： Lyle J. Arnold, Jr. , Mark A. Reynolds , Cristina Giachetti , Alexandre V. Lebedev

IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C12N15/113 , C12Q1/68 , A01N43/04 , C07H19/00

CPC分类号： C12N15/1131 , A61K48/00 , C07H21/00 , A61K38/00

摘要： Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target ribonucleic acid sequences, and in treating disease conditions relating to such sequences.

摘要翻译： 公开了嵌合寡核苷酸化合物及其制备和配制方法。化合物和组合物可用于激活核糖核酸酶-H介导的靶核糖核酸序列的切割，以及用于治疗与这些序列有关的疾病状况。