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1.发明授权公开(公告)号：US06380169B1
公开(公告)日：2002-04-30
申请号：US08299931
申请日：1994-08-31
申请人： Thomas H. Adams , Mark A. Reynolds
发明人： Thomas H. Adams , Mark A. Reynolds
IPC分类号： A01M4304
CPC分类号： C12N15/113 , A61K38/00 , A61K49/085 , A61K49/126 , C07H21/00 , C07H23/00 , C12N2310/3511 , C12N2310/3535
摘要： Compositions, formulations and methods for inhibiting messenger RNA translation using anti-sense oligonucleosides containing 5′-cap cleavage moieties are described.
摘要翻译： 描述了使用含有5'-帽切割部分的反义寡核苷酸抑制信使RNA翻译的组合物，制剂和方法。
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公开(公告)号：US5585481A
公开(公告)日：1996-12-17
申请号：US182666
申请日：1994-01-14
CPC分类号： C07H21/00 , C07F9/2408
摘要： A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.
摘要翻译： 具有具有配体的非核苷酸单体单元的多功能试剂和与非核苷酸单体单元连接的第一和第二偶联基团。 配体可以是化学部分，例如标记或嵌入剂，或可以连接到这种部分的连接臂。 这种试剂允许制备通用的核苷酸/非核苷酸聚合物，具有任何所需的核苷酸和非核苷酸单体单元序列，后者各自具有所需的配体。 这些聚合物可以例如用作可以显示增强的灵敏度的探针和/或能够检测核苷酸属的核苷酸，其中每个物种具有由不感兴趣的不同序列桥接的共同目标核苷酸序列。
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3.发明授权Method for inhibiting RNA translation using chimeric oligonucleoside compounds 失效使用嵌合寡核苷酸化合物抑制RNA翻译的方法公开(公告)号：US06262036B1
公开(公告)日：2001-07-17
申请号：US09490774
申请日：2000-01-24
IPC分类号： A01N6100
CPC分类号： C12N15/1131 , A61K38/00 , A61K48/00 , C07H21/00
摘要： Chimeric oligonucleoside compounds, and methods of preparing and formulating the same, are disclosed. The compounds and compositions are useful in activating RNaseH-mediated cleavage of target ribonucleic acid sequences, and in treating disease conditions relating to such sequences.
摘要翻译： 公开了嵌合寡核苷酸化合物及其制备和配制方法。 化合物和组合物可用于激活核糖核酸酶-H介导的靶核糖核酸序列的切割，以及用于治疗与这些序列有关的疾病状况。
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公开(公告)号：US20190290550A1
公开(公告)日：2019-09-26
申请号：US16360394
申请日：2019-03-21
申请人： Huakun XU , Su-Ping WANG , Mark A. REYNOLDS , Abraham SCHNEIDER
发明人： Huakun XU , Su-Ping WANG , Mark A. REYNOLDS , Abraham SCHNEIDER
IPC分类号： A61K6/00 , A61K31/155 , A61K31/14 , A61K33/38 , A61K33/42
摘要： The present invention provides metformin-containing dental materials that can be widely applied in a variety of dental applications. The metformin-containing dental materials of the invention include metformin-containing dental primers, metformin-containing dental adhesives, metformin-containing dental resins, metformin-containing dental composites, metformin-containing dental bonding systems and the like, as well as metformin-containing dental cements, metformin-containing dental sealants, metformin-containing dental bases and metformin-containing dental liners.
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公开(公告)号：US20080118893A1
公开(公告)日：2008-05-22
申请号：US11817963
申请日：2006-03-07
IPC分类号： A61C8/00
CPC分类号： A61K9/0063 , A61C8/0006 , A61C8/0022 , A61C19/06
摘要： An implantable dental screw comprising (i) an elongated body portion, which comprises a distal end and an external surface, which is axially threaded, (ii) a top portion, which is connected to the body portion at an end opposite to the distal end, and which comprises a proximal end, which comprises a seat that engages a tool for securing the screw into an osseotomy site and a chamfer that engages a dental prosthesis, and an external surface, (iii) at least one core channel disposed longitudinally within the screw and open at the proximal end and, optionally, at the distal end, and (iv) a plurality of delivery channels disposed within the body portion, each of which connects a core channel with the exterior of the screw; and a method of implanting the dental screw into a patient.
摘要翻译： 一种可植入牙科螺钉，包括（i）细长主体部分，其包括远端和外表面，所述远端和外表面是轴向螺纹的，（ii）顶部，其在与所述远端相对的端部连接到所述主体部分 并且其包括近端，其包括与用于将所述螺钉固定到骨切开术位置的工具的座，以及接合牙科假体的倒角和外表面，（iii）至少一个芯通道，其纵向设置在所述内窥镜 螺钉并在近端开口，并且可选地在远端处打开，以及（iv）设置在主体部分内的多个输送通道，每个输送通道将芯通道与螺钉的外部连接; 以及将牙科螺钉植入患者体内的方法。
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公开(公告)号：US07080031B2
公开(公告)日：2006-07-18
申请号：US10060412
申请日：2002-02-01
申请人： James Q. Crowe , Russell A Rushmeier , Indraneel Das , Paul J. Koster , Jose F. Alvarez , Mark A. Reynolds , Lorraine Lotosky
发明人： James Q. Crowe , Russell A Rushmeier , Indraneel Das , Paul J. Koster , Jose F. Alvarez , Mark A. Reynolds , Lorraine Lotosky
IPC分类号： G06F17/60
CPC分类号： G06Q40/02 , G06Q20/108 , G06Q20/1085 , G06Q40/00
摘要： A method and computer program product are presented for selecting and arranging an appropriate combination of network components, or elements, in a communications network. The selection of network components is done in a manner that maximizes the net present value of cash flow resulting from the provision of communications services between nodes of the network. The method comprises the steps of receiving information that constrains network design and price establishment, and then using the constraint information to select a combination of network components for each link in the communications network. According to the invention, the selection of network components is performed for each of several successive time periods, effectively planning the evolution of the network. The selections are made so that the network components satisfy demand over time while maximizing the net present value of the cash flow that results from the provision of communications services.
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公开(公告)号：US06031091A
公开(公告)日：2000-02-29
申请号：US908535
申请日：1997-08-07
CPC分类号： C07H21/00 , C07F9/2408
摘要： A versatile reagent with a non-nucleotide monomeric unit having a ligand, and first and second coupling groups which are linked to the non-nucleotide monomeric unit. The ligand can be either a chemical moiety, such as a label or intercalator, or a linking arm which can be linked to such a moiety. Such reagent permits preparation of versatile nucleotide/non-nucleotide polymers, having any desired sequence of nucleotide and non-nucleotide monomeric units, each of the latter of which bear a desired ligand. These polymers can for example, be used as probes which can exhibit enhanced sensitivity and/or which are capable of detecting a genus of nucleotides each species of which has a common target nucleotide sequence of interest bridged by different sequences not of interest.
摘要翻译： 具有具有配体的非核苷酸单体单元的多功能试剂和与非核苷酸单体单元连接的第一和第二偶联基团。 配体可以是化学部分，例如标记或嵌入剂，或可以连接到这种部分的连接臂。 这种试剂允许制备通用的核苷酸/非核苷酸聚合物，具有任何所需的核苷酸和非核苷酸单体单元序列，后者各自具有所需的配体。 这些聚合物可以例如用作可以显示增强的灵敏度的探针和/或能够检测核苷酸属的核苷酸，其中每个物种具有由不感兴趣的不同序列桥接的共同目标核苷酸序列。
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公开(公告)号：US20100129822A1
公开(公告)日：2010-05-27
申请号：US12625609
申请日：2009-11-25
申请人： Amara SIVA , Mark A. REYNOLDS
发明人： Amara SIVA , Mark A. REYNOLDS
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6853 , C12Q2600/178 , C12Q2565/537 , C12Q2565/525 , C12Q2537/143 , C12Q2525/301
摘要： Compositions and methods are provided for the detection of small RNA target nucleic acids, preferably miRNA target nucleic acids, wherein the compositions and methods provide for sensitive and specific detection of the target nucleic acids. The compositions and methods include using one or more of a first amplification oligomer that is preferably an extender primer, a target capture oligomer that is preferably at least partially double stranded, a promoter primer/provider, a reverse primer that is preferably a universal primer and a detection probe. The compositions and methods are useful for diagnostics, prognostics, monitoring the effectiveness of treatment and/or determining a treatment.
摘要翻译： 提供组合物和方法用于检测小RNA靶核酸，优选miRNA靶核酸，其中组合物和方法提供对靶核酸的敏感和特异性检测。 组合物和方法包括使用一种或多种优选扩增引物的第一扩增寡聚物，优选至少部分双链的靶捕获低聚物，启动子引物/提供者，优选通用引物的反向引物和 检测探针。 组合物和方法可用于诊断，预后，监测治疗的有效性和/或确定治疗。
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公开(公告)号：US20080032835A1
公开(公告)日：2008-02-07
申请号：US11833856
申请日：2007-08-03
申请人： Mark A. Reynolds
发明人： Mark A. Reynolds
IPC分类号： F16H59/00
CPC分类号： B62M9/136
摘要： A multiple sprocket chain guide includes a guide structure mounted onto the movable metal cage of a conventional front bicycle derailleur such that the entire guide structure moves between inner and outer gear positions with the movable cage. The guide structure includes opposing outer and inner guide plates and a bridge that is rigidly connected between the guide plates to define a chain guide channel for directing the bicycle's chain onto a selected front sprocket. When the derailleur is positioned to guide the chain onto the outer front sprocket, the outer guide plate is positioned over the outer bash guard such that a gap there between is smaller than the height of the chain, thereby preventing derailment. When the derailleur is positioned to guide the chain onto the inner front sprocket, the inner guide plate is positioned over an inner plate to prevent derailment in a similar manner.
摘要翻译： 多个链轮链条引导件包括安装在传统的前部自行车拨链器的可动金属保持器上的引导结构，使得整个引导结构在可移动的保持架的内外齿轮位置之间移动。 引导结构包括相对的外引导板和内引导板以及刚性地连接在引导板之间的桥，以限定用于将自行车链条引导到所选择的前链轮上的链条引导通道。 当拨链器定位成将链条引导到外前链轮上时，外引导板定位在外防护罩上方，使得其间的间隙小于链条的高度，从而防止脱轨。 当拨链器定位成将链条引导到内侧前链轮上时，内部引导板位于内部板上以防止类似的脱轨。
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公开(公告)号：US06316608B1
公开(公告)日：2001-11-13
申请号：US09532656
申请日：2000-03-20
IPC分类号： C07H2104
CPC分类号： C12Q1/6837 , C12Q2545/114
摘要： Methods are provide for determining the relative amounts of individual polynucleotides in a complex mixture. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array having element disposed at discrete locations on a substrate. The elements comprise two or more distinct polynucleotides that are combined prior to arraying. The level of fluorescence associated with each element provides a measure of its relative amount in the mixture.
摘要翻译： 提供了确定复合混合物中各个多核苷酸的相对量的方法。 在荧光标记之后，多核苷酸在杂交条件下与具有设置在基底上离散位置的元件的阵列接触。 这些元件包括在排列之前组合的两个或更多个不同的多核苷酸。 与每个元素相关的荧光水平提供了其在混合物中的相对量的量度。
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